[1] 王 景,张海丽,滕 林,等. 激光联合全蝎软膏治疗增生性瘢痕疗效评价[J].中国美容医学,2020,(6):27-31.
　 WANG Jing,ZHANG Hai-li,TENG Lin,et al. Assessment of Laser Combined with Scorpion Ointment in the Treatment ofHypertrophic Scar[J].Medical Aesthetics and Beauty,2020,(6):27-31.
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年6期
页码:
27-31
栏目:
出版日期:
2020-06-10

文章信息/Info

Title:
 Assessment of Laser Combined with Scorpion Ointment in the Treatment of
Hypertrophic Scar
文章编号:
1008-6455(2020)06-0027-05
作者:
 王 景; 张海丽; 滕 林; 郭伟光
Author(s):
 WANG Jing; ZHANG Hai-li; TENG Lin;  GUO Wei-guang
关键词:
 [关键词]全蝎软膏; 半导体激光; 增生性瘢痕; 早期治疗; Smad 4蛋白; TGF-β通路
Keywords:
 Key words: scorpion ointment;  semiconductor saser;  hypertrophic scar;  preemptive therapy;  smad 4 Protein;  TGF-β pathway
分类号:
R619+.6
文献标志码:
A
摘要:
[摘要]目的：观察并探讨激光联合全蝎软膏对兔耳早期增生性瘢痕的治疗效果。方法：将16只新西兰大白兔随机分为空白对
照组、模型组、全蝎软膏组和联合组，每组4只；建模后立即对全蝎软膏组和联合组患处进行药物涂抹或激光照射治疗，对
照组和模型组用PBS处理；于治疗后的第50d取各组动物皮肤织进行病理、酶联免疫法（ELISA）、荧光定量PCR和Smad 4蛋白
检测。结果：与空白对照组相比，模型组兔耳术后形成增生性瘢痕，联合组和全蝎软膏组经治疗后无瘢痕出现；HE染色结
果显示，经激光联合全蝎软膏治疗后组织纤维化程度明显减轻；ELISA和荧光定量PCR检测结果表明，联合组与模型组相比，
I型胶原蛋白（Col I）、Ⅲ型胶原蛋白（Col Ⅲ）、肿瘤坏死因子α（TNF-α）及MMP的表达量均显著降低（P ＜0.05）；
Western blot结果证实了激光联合全蝎软膏治疗后可显著抑制组织内Smad 4蛋白的表达（P ＜0.05），从而调控TGF-β细胞通
路而抑制增生性瘢痕的形成。结论：本研究证实了激光联合全蝎软膏具有治疗HTS的作用，并为临床上治疗HTS提供新途径。

Abstract:
Abstract: Objective To observe and explore the therapeutic effect of laser combined with scorpion ointment on early
hypertrophic scar in rabbit ears. Methods The sixteen New Zealand white rabbits were randomly divided into blank control
group, model group, scorpion ointment group and combined group. After modeling, the patients in the treatment group were
immediately treated with drug smear or laser irradiation, while those in the control and model groups were treated with PBS.
On the fiftieth day after treatment, the skin tissues of each group were taken for pathological examination, enzyme-linked
immunosorbent assay (ELISA), fluorescence quantitative PCR and Smad 4 protein detection. Results Compared with the
control group, hypertrophic scar was formed in the model group after ear surgery, and no scar appeared in the laser combined
with scorpion ointment group after treatment. The results of HE staining showed that the degree of tissue fibrosis was
significantly reduced after laser combined with scorpion ointment treatment. The results of ELISA and quantitative fluorescence
PCR showed that the expressions of Col I, Col Ⅲ, TNF-a and MMP in the combined treatment group were significantly lower
than those in the model group (P ＜0.05). The western blot results confirmed that laser combined with scorpion ointment could
significantly inhibit the expression of Smad 4 protein in tissues (P ＜0.05), thereby regulating the TGF-β cell pathway and
inhibiting the formation of hypertrophic scars. Conclusion This study confirms that laser combined with scorpion ointment can
be used to treat HTS, and provides a new way for clinical treatment of HTS.

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更新日期/Last Update: 2020-06-24