水杨酸换肤结合点阵激光在女性黄褐斑面部美容中的应用?/html>-《中国美容医学》

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Title:: Application of Salicylic Acid Skin Changing Combined with Dot Matrix Laser in Facial Beauty of Female Chloasma

文章编号:: Key words: female chloasma salicylic acid skin r

作者:: 王洪燕

Author(s):: WANG Hong-yan

关键词:: 关键词]女性黄褐斑; 水杨酸换肤; 点阵激光; 面部美容效果; 皮肤特征; 氧化应激反应; 复发

Keywords:: Key words: female chloasma; salicylic acid skin resurfacing; fractional laser; facial cosmetic effects; skin characteristics; oxidative stress; relapse

分类号:: R758.4+ 2

文献标志码:: A

摘要:: [摘要]目的：对女性黄褐斑采用水杨酸换肤、点阵激光结合方案行前瞻性研究，分析其对患者面部美容效果、氧化应激反应及预后的影响。方法：采用前瞻性随机对照研究方法选择2017年6月-2019年7月笔者医院就诊的112例女性黄褐斑患者为研究对象，以随机数字表法分为观察组（n＝56）和对照组（n＝56）。对照组给予点阵激光治疗，观察组给予水杨酸换肤结合点阵激光治疗，均治疗20周。比较两组疗效、面部美容满意度、不良反应及治疗前后皮肤检测仪（VISIA）皮肤特征评分、皮损评分、皮肤水分情况、血清氧化应激反应指标［丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）及超氧化物歧化酶 (SOD)］水平，并于治疗20周后行6个月随访，比较两组治疗后3个月、6个月复发率。结果：①疗效及皮损控制：观察组总有效率为87.50%，高于对照组的71.43%，治疗10周、20周后皮损评分低于对照组（P＜0.05）；②皮肤特征及水分情况：与治疗前比较，治疗10周、20周后两组各项VISIA皮肤特征评分降低，经表皮水分流失减少，皮肤角质层含水量提高，且观察组均优于对照组（P＜0.05）；③氧化应激：治疗10周、20周后，两组血清MDA水平较治疗前降低，GSH-Px、SOD水平较治疗前提高，观察组变化幅度高于对照组（P＜0.05）；④满意度：调查结果显示，观察组面部美容总满意度为96.43%，高于对照组的80.36%（P＜0.05）；⑤两组治疗期间不良反应发生率比较，差异无统计学意义（P＞0.05）；⑥复发率：随访统计结果显示，排除脱落病例，两组治疗后3个月复发率差异无统计学意义（P＞0.05），但治疗后6个月，观察组复发率为5.45%，低于对照组18.18%（P＜0.05）。结论：水杨酸换肤、点阵激光结合方案治疗女性黄褐斑临床疗效显著，且安全性良好，在控制皮损、改善皮肤特征、水分、等方面均有积极作用，同时可减轻机体氧化应激反应，提高患者面部美容满意度，降低复发率，预后良好。

Abstract:: Abstract: Objective To conduct a prospective study on women with chloasma who used salicylic acid skin resurfacing and fractional laser combined program to analyze the effects on facial beauty, oxidative stress and prognosis. Methods A prospective randomized controlled study method was used to select 112 female patients with chloasma in our hospital from June 2017 to July 2019, and were divided into an observation group (n=56) and a control group (n=56) based on a random number table. The control group was given fractional laser, and the observation group was given salicylic acid skin resurfacing combined with fractional laser. Both were treated for 20 weeks. The effi cacy, satisfaction degree of facial aesthetics, adverse reactions, skin feature score, skin lesion score, and skin moisture of the skin detector (VISIA), serum oxidative stress response indexes [malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD)] levels before treatment, 10 weeks and 20 weeks after treatment were compared between the two groups. A 6-month follow-up was conducted after 20 weeks of treatment, and the recurrence rates of the two groups were statistically compared at 3 and 6 months after treatment. Results ①Effi cacy and skin lesion control:The total eff ective rate of the observation group was 87.50% , which was higher than 71.43% of the control group. The skin lesion scores after 10 and 20 weeks of treatment were lower than those of the control group (P＜0.05).② Skin characteristics and moisture status: Compared with before treatment, after 10 weeks and 20 weeks of treatment, the VISIA skin characteristic scores of the two groups decreased, the loss of transepidermal water was reduced, and the water content of the stratum corneum increased, and the observation group was better than the control group (P＜0.05).③ Oxidative stress: After 10 weeks and 20 weeks of treatment, the serum MDA levels of the two groups were lower than before treatment, and the levels of GSH-Px and SOD were higher than before treatment. The change in the observation group was higher than that in the control group (P＜0.05). ④Satisfaction: The survey results showed that the total satisfaction degree of facial beauty in the observation group was 96.43% , which was higher than that of the control group by 80.36% (P＜0.05)⑤There was no signifi cant diff erence in the incidence of adverse reactions between the two groups during the treatment period (P＞0.05). ⑥Recurrence rate: The statistical results of follow-up showed that the drop-out cases were excluded, and there was no signifi cant diff erence in the recurrence rate of the two groups after 3 months of treatment (P＞0.05). But 6 months after treatment, the recurrence rate in the observation group was 5.45% , which was lower than 18.18% in the control group (P＜0.05). Conclusion The combination of salicylic acid skin resurfacing and fractional laser treatment has a signifi cant clinical eff ect and good safety. in the treatment of female chloasma. It has a positive eff ect in controlling skin lesions, improving skin characteristics, moisture, etc. It can also reduce the body’s oxidative stress response, improve the satisfaction degree of the facial beauty of the patients, reduce recurrence rate, and have a good prognosis.?/span>

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

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