[1]卫泽雨,丁炜蕴,倪春雅,等.油脂分泌旺盛的脱发女性与正常女性头皮微生物结构差异及干预效果研究[J].中国美容医学,2024,(10):26-31.
　WEI Zeyu,DING Weiyun,NI Chunya,et al.The Difference of Structure of Scalp Microbiome and the Effect of Intervention Between Women with and without Alopecia Accompanied With Excessive Oil Secretion[J].Medical Aesthetics and Beauty,2024,(10):26-31.
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油脂分泌旺盛的脱发女性与正常女性头皮微生物结构差异及干预效果研究()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2024年10期
页码:
26-31
栏目:
出版日期:
2024-09-26

文章信息/Info

Title:
The Difference of Structure of Scalp Microbiome and the Effect of Intervention Between Women with and without Alopecia Accompanied With Excessive Oil Secretion
文章编号:
1008-6455（2024）10-0026-06
作者:
卫泽雨1; 丁炜蕴1; 倪春雅2; 沈林霞1; 吴旭升3; 孙 广4; 刘庆梅1
（1.复旦大学附属华山医院皮肤科，上海市皮肤病研究所 上海 200040；2.上海市静安区中心医院皮肤科 上海 200040； 3.浙江中医药大学 浙江 杭州 310053；4.杭州钛美生物科技有限公司 浙江 杭州 310009）
Author(s):
WEI Zeyu1;  DING Weiyun1;  NI Chunya2;  SHEN Linxia1;  WU Xusheng3; SUN Guang4; LIU Qingmei1
( 1.Department of Dermatology, Huashan Hospital, Fudan University, Shanghai Institute of Dermatology, Shanghai 200040, China; 2.Department of Dermatology, Jingan District Central Hospital, Shanghai 200040, China; 3.Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China; 4.Taimei Biotechnology Co. Ltd, Hangzhou 310009, Zhejiang, China)
关键词:
Keywords:
alopecia;  probiotics;  microbiome characteristics;  scalp
分类号:
R756
文献标志码:
A
摘要:
[摘要]目的：评估油脂分泌旺盛的脱发女性与健康女性头皮微生物的结构差异，观察微生态制剂干预后微生物结构变化。方法：选取2022年6月20日-2022年7月20日招募的20～35岁女性56名，按入组标准分为健康组（n=24）和油脂分泌旺盛的脱发组（n=32），利用细菌16sRNA序列V3-V4区和真菌ITS高通量测序技术分析健康女性及油脂分泌旺盛的脱发女性头皮微生物特征及干预前后的差异，同时对脱发计数和头皮油脂变化进行评估，并对结果进行统计分析。结果：与正常女性相比，油脂分泌旺盛的脱发女性具有更高的细菌群落丰富度（P＜0.05），群落结构及丙酸杆菌等多种细菌的相对丰度与正常女性存在显著差异（P＜0.05）；油脂分泌旺盛的脱发女性真菌群落丰富度、结构与正常女性无明显差异。微生态制剂干预后，油脂分泌旺盛的脱发女性脱发及头皮油脂情况有明显好转（P＜0.05）。结论：油脂分泌旺盛的脱发女性与健康女性的头皮微生物结构存在显著的差异，微生态制剂对头皮微生物特征有调节作用；研究为从微生态角度防治脱发提供依据。
Abstract:
Objective To explore the differences in scalp microbiome structure between women with and without alopecia accompanied with excessive oil secretion and to observe the changes in this structure following the intervention of probiotics preparation. Methods A total of 56 women aged 20-35 recruited between June 20th 2022 and July 20th 2022 were enrolled and divided into two groups based on inclusion criteria: the healthy group (n=24) and the alopecia accompanied with excessive oil secretion group (n=32). High-throughput sequencing technology targeting the bacterial 16sRNA sequence V3-V4 region and the fungal ITS sequence was employed. This approach was used to analyze the differences in scalp microbiome characteristics between the two groups and to evaluate the effects of the probiotics intervention. Additionally, hair loss count and scalp lipid changes were assessed, followed by statistical analysis. Results Compared with healthy women, those with alopecia accompanied with excessive oil secretion exhibited a significantly higher abundance of bacterial microbiome (P＜0.05), with notable differences in the microbiome structure and the relative abundance of various bacteria such as Cutibacterium (P＜0.05). However, there were no significant differences in the abundance and structure of the fungal microbiome between the two groups. Post intervention with the probiotics, significant improvements were observed in hair loss and scalp lipid conditions among women with alopecia accompanied with excessive oil secretion (P＜0.05). Conclusion There are marked differences in the scalp microbiome structure between women with and without alopecia accompanied with excessive oil secretion. Probiotics appears to moderate the characteristics of scalp microbiome. This research provides evidence supporting the prevention and treatment of alopecia accompanied with excessive oil secretion from a microbiome perspective
更新日期/Last Update: 2024-09-29