[1]贾 菲,吴风琴,张 倩,等.果酸治疗黄褐斑30例临床分析[J].中国美容医学,2018,(09):21-24.
　JIA Fei,WU Feng-qin,ZHANG Qian,et al.Clinical Efficacy of Alpha-hydroxy Acid for Treatment of 30 Cases of Melasma[J].Medical Aesthetics and Beauty,2018,(09):21-24.
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果酸治疗黄褐斑30例临床分析
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2018年09期
页码:
21-24
栏目:
出版日期:
2018-10-10

文章信息/Info

Title:
Clinical Efficacy of Alpha-hydroxy Acid for Treatment of 30 Cases of Melasma
文章编号:
1008-6455(2018)09-0021-04
作者:
贾 菲; 吴风琴; 张 倩; 李春英; 坚 哲
Author(s):
JIA Fei;  WU Feng-qin;  ZHANG Qian;  LI Chun-ying;  JIAN Zhe
关键词:
[关键词]黄褐斑; 果酸; 化学剥脱; 疗效; 外用药
Keywords:
Key words: melasma;  alpha-hydroxy acid;  chemexfoliation;  efficacy;  external application drugs
分类号:
R758.4+2
文献标志码:
A
摘要:
[摘要]目的：观察果酸治疗黄褐斑的临床效果和安全性，掌握治疗的方法和适应证。明确果酸治疗黄褐斑的疗效、相关生
物学指标的变化及患者的满意度评价。方法：本试验采取自身对照分析，共纳入30例行果酸治疗的黄褐斑患者。使用果酸
(20%～70%)行剥脱治疗,每2周1次,共治疗4次。分别于治疗前、治疗后（第15天、30天、45天、60天）进行无创性皮肤测试
仪检测皮肤黑色素及红色素，并评估术后MASI评分，收集患者主观感受及疗效。结果：随着治疗时间及次数的增加，果酸治
疗黄褐斑患者皮损处黑色素、红色素数值降低，且较治疗前差异有统计学意义（P ＜0.05）；疗程结束时评估疗效，基本治
愈10例，明显改善15例，轻度改善2例，改善不明显或加重3例，有效率90%；患者对果酸治疗满意度较高，且患者皮肤整体
光泽度、肤色均匀性及黄褐斑皮损均改善，随着时间推移改善趋势越来越明显。结论：果酸治疗黄褐斑是一种安全、有效的
治疗方式，可通过降低黑色素、红色素指标从而改善皮损处色斑。
Abstract:

Abstract: Objective To explore the clinical effect and safety of alpha-hydroxy acid in the treatment of melasma, and clarify
the efficacy, related biological indicators and patient satisfaction were evaluated. Methods Self-control analysis was performed
in this study.30 patients with melasma treated with alpha-hydroxy acid were included. More specifically, they received an
exfoliation treatment with alpha-hydroxy acid (20% to 70%) once every two weeks for a total of four times. Skin melanin and
red pigment were detected by non-invasive skin tester before and after treatment (15d, 30d, 45d, and 60d), the MASI score
after surgery was evaluated, and the patients’subjective feelings were also collected. Results The level of the melanin and
red pigment in the skin lesions of melasma patients were decreased with the increase of time and frequency, and the difference
was statistically significant before treatment (P ＜0.05). Assessment of the therapeutic efficacy at the end of treatment: basic
cure (n =10), significantly improved (n =15), slightly improved (n =2), insignificant or aggravated (n =3), about 90% efficiency.
Patients were more satisfied with their treatment. The skin gloss, color even and lesions of melasma patients had improved.
The effect was getting better with the extension of treatment time. Conclusion Alpha-hydroxy acid was a safe and effective
treatment for melasma. It did this through the reduction of melanin and red pigment levels and the improvement of skin lesions.

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更新日期/Last Update: 2018-10-31