[1]刘 蓓,王 芳,陈 琳,等. CD100在正常皮肤、急性创面及慢性创面中的表达研究[J].中国美容医学,2018,(10):133-136.
　LIU Bei,WANG Fang,CHEN Lin,et al.Expression of CD100 in Normal Tissue, Acute Wound and Chronic Wound[J].Medical Aesthetics and Beauty,2018,(10):133-136.
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 CD100在正常皮肤、急性创面及慢性创面中的表达研究
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2018年10期
页码:
133-136
栏目:
出版日期:
2018-11-10

文章信息/Info

Title:
Expression of CD100 in Normal Tissue, Acute Wound and Chronic Wound
文章编号:
1008-6455（2018）10-0133-04
作者:
刘 蓓1; 3; 王 芳2; 3; 陈 琳3; 余 州3; 宋雅娟3; 王 彤3; 苏映军3
Author(s):
LIU Bei1; 3 ; WANG Fang2; 3; CHEN Lin3; YU Zhou3; SONG Ya-juan3; WANG Tong3; SU Ying-jun3
关键词:
 ; [关键词]创面愈合; CD100; 免疫组织化学法; 急性创面; 慢性创面
Keywords:
Key words: wound healing;  CD100;  immunohistochemical method;  acute wound;  chronic wound
分类号:
R64
文献标志码:
A
摘要:
[摘要]目的：研究CD100分子在正常皮肤组织、急性创面及慢性创面中的表达。方法：采用免疫组化法检测外科手术切除的
20例正常皮肤组织、30例急性创面及20例慢性创面边缘全层皮肤组织CD100的表达水平。结果：正常皮肤CD100主要表达于表
皮，其中胞膜高表达，真皮不表达；急性创面中表皮CD100膜表达水平显著降低；慢性创面中CD100在表皮组织低表达而真皮
表达显著升高。各组间表皮胞膜、胞质及真皮中CD100表达水平比较，差异有统计学意义（P ＜0.05）。结论：在皮肤组织损
伤早期，表皮组织膜型CD100的脱落可能对创面愈合早期发挥重要作用，慢性创面CD100表皮持续性低表达、真皮高表达的状
态可能和创面难愈有关。

Abstract:
Abstract: Objective To investigate the expression of CD100 in normal skin tissue, acute wound and chronic wound tissues.
Methods Immunohistochemical method was used to detect the expression of CD100 in 20 cases of normal skin tissues, 30
cases of acute wound and 20 cases of chronic wound tissues. Results The expression of CD100 in normal skin tissues was
mainly expressed in the epidermis, and was not expressed in dermis. The expression level of membrane CD100 of epidermis
in acute wound was significantly reduced. In the chronic wound, the expression level of CD100 in the epidermis was low, but
the expression level in the dermis was increased significantly. The expression levels of CD100 in membrane and cytoplasm of
epidermal and in dermis had statistical difference in the three groups (P ＜0.05). Conclusion In the early skin tissue damage,
shedding of membrane CD100 in epidermis may play an important role in acute wound healing. In chronic wounds, the
condition of low CD100 expression in epidermis and the high CD100 expression in epidermis may be related to the difficulty of
chronic wound healing.

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更新日期/Last Update: 2018-11-22