[1]孙之中,刘朝红. 薇诺娜保湿霜治疗特应性皮炎疗效及对皮肤屏障功能的影响研究[J].中国美容医学,2018,(11):49-52.
　SUN Zhi-zhong,LIU Zhao-hong. Therapeutic Effect of Winona Moisturizer on Atopic Dermatitis and its Effect on Skin Barrier Function[J].Medical Aesthetics and Beauty,2018,(11):49-52.
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 薇诺娜保湿霜治疗特应性皮炎疗效及对皮肤屏障功能的影响研究
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2018年11期
页码:
49-52
栏目:
出版日期:
2018-12-10

文章信息/Info

Title:
 Therapeutic Effect of Winona Moisturizer on Atopic Dermatitis and its Effect on Skin Barrier Function
文章编号:
1008-6455（2018）11-0049-04
作者:
孙之中; 刘朝红
Author(s):
SUN Zhi-zhong; LIU Zhao-hong
关键词:
 ; [关键词] 特应性皮炎; 薇诺娜保湿霜; 丙酸氟替卡松乳膏; 神经酰胺; 皮肤屏障功能; 马齿苋
Keywords:
Key words: atopic dermatitis;  winona moisturizer;  fluticasone propionate cream;  ceramide;  skin barrier function;  purslane
分类号:
R751.05
文献标志码:
A
摘要:
[摘要]目的:观察薇诺娜保湿霜治疗特应性皮炎（atopic dermatitis,AD）疗效及对皮肤屏障功能的影响。方法:选取笔者
医院2016年3月-2018年3月收治的82例特应性皮炎患者，按随机数字表法分为观察组与对照组，每组各41例。对照组外用丙
酸氟替卡松乳膏，观察组外用丙酸氟替卡松乳膏联合薇诺娜保湿霜，两组患者均治疗2个月。比较两组总有效率、治疗前
后表皮组织的丝聚蛋白(filaggrin，Flg)、兜甲蛋白(loricrin，Lor)、细胞角蛋白14(cytokeratin 14，K14)、细胞角蛋白
17(eytokeratin 17，K17)、客观体征(红斑、表皮剥脱、苔癣样变)评分、皮肤美观度评分及不良反应发生率。结果: 观察组
治疗总有效率95.12%，显著高于对照组的80.49%，差异有统计学意义(P ＜0.05)。两组治疗前表皮组织中Flg、Lor、K14、K17
表达差异无统计学意义(P ＞0.05)。治疗后，两组患者表皮组织中Flg、Lor表达均上调，K14、K17均下调，差异有统计学意义
(P ＜0.05)。观察组治疗后的表皮组织中Flg、Lor表达高于同期对照组，K14、K17表达低于同期对照组(P ＜0.05)。两组治疗
前的红斑评分、表皮剥脱评分、苔癣样变评分、美观度评分比较差异均无统计学意义(P ＞0.05)。治疗后，两组的红斑评分、
表皮剥脱评分、苔癣样变评分、美观度评分均较治疗前降低，且观察组低于同期对照组(P ＜0.05)。两组患者治疗期间均未见
明显不良反应。结论：在糖皮质激素基础上联合应用薇诺娜保湿霜治疗特应性皮炎可有效改善患者皮肤屏障功能，促进客观
体征消退，提高皮肤美观度，疗效优于单纯糖皮质激素治疗，且无明显不良反应，使用方便，值得推广。

Abstract:
Abstract: Objective To observe the effect of Winona moisturizer on the efficacy and skin barrier function of atopic dermatitis
(AD). Methods A total of 82 patients with atopic dermatitis admitted to our hospital from March 2016 to March 2018 were
randomly divided into observation group and control group, with 41 cases in each group. The control group was treated with
fluticasone propionate cream, and the observation group was treated with fluticasone propionate cream and Winona moisturizer.
Both groups were treated for 2 months. The total effective rate, filaggrin (Flg), porcine protein (Lor), cytokeratin 14 (K14),
cytokeratin 17 (K17) of epidermal tissue, and objective signs (erythema, epidermal exfoliation, Moss-like change) score and
skin aesthetics score before treatment and after treatment, incidence of adverse reactions were compared between the two
groups. Results The total effective rate of the observation group was 95.12%, which was significantly higher than 80.49% in
the control group (P ＜0.05). There were no significant difference in the expression of Flg, Lor, K14 and K17 of epidermal tissue
between the two groups before treatment (P ＞0.05). After treatment, the expressions of Flg and Lor of the epidermal tissues in
both groups were up-regulated than before treatment, while the expressions of K14 and K17 were down-regulated than before
treatment (P ＜0.05). The expression of Flg and Lor in the epidermal tissue of the observation group were higher than those of
the control group of same period, and the expression of K14 and K17 in the observation group were lower than those in the
control group of same period (P ＜0.05). There were no significant differences in the erythema score, epidermal exfoliation
score, lichen-like change score and aesthetic score between the two groups before treatment (P ＞0.05). After treatment, the
erythema score, epidermal exfoliation score, lichen-like score, and aesthetic score of the two groups were lower than those
before treatment, and the observation group were lower than the control group of same period (P ＜0.05). No significant adverse
reactions were observed during the two treatment periods. Conclusion Glucocorticoid combined with Winona moisturizer
for the treatment of atopic dermatitis can effectively improve the skin barrier function of children, promote the resolution of
objective signs, improve skin aesthetics, better efficacy than glucocorticoid treatment, and no obvious adverse reactions, use
convenient, worth promoting.

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更新日期/Last Update: 2018-12-17