自噬、miRNA与增生性瘢痕的研究进展<br />-《中国美容医学》

文章信息/Info

Author(s):: SHI Min1; LI Na2 ; CHEN Lei1; LIU Zhao-wang1; WEI Chao-peng1; FENG Xing-hua1

Keywords:: Key words: autophagy; miRNA; hypertrophic scar; fibroblast; extra cellula rmatrix; molecular mechanism

摘要:: [摘要]皮肤创伤的修复是一个高度协调、复杂的愈合过程，涉及因素众多，修复中成纤维细胞大量增殖、分化，加之胶原纤
维形成和细胞外基质沉积，从而形成了增生性瘢痕。虽然瘢痕愈合可恢复皮肤屏障结构的完整性，但瘢痕的挛缩、畸形不仅
影响美观，降低皮肤功能，更重要的是极大地影响了患者的身心健康。近年来,有研究表明，miRNA和细胞自噬参与调控纤维
化疾病和创伤修复中成纤维细胞，两者可相互影响，共同参与调控增生性瘢痕的形成。通过分析、总结miRNA在瘢痕组织中
的分子机制，以及细胞自噬如何调控修复创面中成纤维细胞的增殖、分化，胶原代谢及ECM的合成等，实现在基因水平和分
子水平上对增生性瘢痕形成的调控作用，以期为增生性瘢痕的防治提供新的平台和思路。

Abstract:: Abstract: The repair of skin wounds is a highly coordinated and complex healing process involving many factors, and the
proliferation and differentiation of fibroblasts, the formation of collagen fibers and the deposition of extracellular matrix to
form hypertrophic scars in repairing. Although scar healing can restore the integrity of the barrier structure of the skin, the
contracture and deformity of the scar not only affects the appearance,decreases the skin function, but more importantly, greatly
affects the patient’s physical and mental health. In recent years, studies have shown that miRNA and autophagy are involved in
the regulation of fibroblasts in fibrotic diseases and wound repair, and they can affect each other and participate in the regulation
of hypertrophic scar formation. By analyzing and summarizing the molecular mechanism of miRNA in scar tissue,and how
autophagy regulates the proliferation, differentiation, collagen metabolism and ECM synthesis of fibroblasts in repairing
wounds, it can achieve hypertrophic scars at the genetic and molecular levels to provide a new platform and ideas for the
prevention and treatment of hypertrophic scars.