泼尼松联合丹参注射液治疗过敏性紫癜疗效分析<br />-《中国美容医学》

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Title:: Effect of Prednisone Combined with Salvia Miltiorrhiza Injection on Allergic Purpura

文章编号:: 1008-6455（2019）07-0027-03

作者:: 温杰¹; 冯冬梅¹; 郝丽莎¹; 周向昭¹; 吴远慧¹; 连晶晶²; 王晓美¹

Author(s):: WEN Jie1; FENG Dong-mei1; HAO Li-sha1; ZHOU Xiang-Zhao1; WU Yuan-hui1; LIAN Jing-jing2; WANG Xiao-mei1

关键词:: [关键词]泼尼松; 丹参注射液; 过敏性紫癜; IL-23; IL-34; 凝血因子

Keywords:: Key words: prednisone; danshen injection; allergic purpura; IL-23; IL-34; clotting factor

分类号:: R751.05

文献标志码:: A

摘要:: [摘要]目的：探讨泼尼松联合丹参注射液治疗过敏性紫癜的疗效及对血清白细胞介素23（IL-23）、白细胞介素34（IL-
34）与凝血因子的影响。方法：选择2015年6月-2018年6月笔者医院接诊的过敏性紫癜患者120例，以随机数表法分为观
察组（n =65）和对照组（n =55），对照组使用泼尼松治疗，观察组在对照组的基础上加用丹参注射液治疗。比较两组临
床疗效、血清IL-23、IL-34、肿瘤坏死因子α（TNF-α）、活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、纤
维蛋白原（FIB）、腹痛、紫癜、关节疼痛消失时间及不良反应发生情况。结果：治疗后，观察组总有效率高于对照组
（P ＜0.05）；两组患者血清IL-23、IL-34、TNF-α水平较治疗前均明显下降，且观察组明显低于对照组，差异有统计学意
义（P＜0.05）；治疗后，两组APTT、PT、FIB水平较治疗前均明显改善（P ＜0.05），且观察组APTT、PT水平均明显高于
对照组，FIB水平低于对照组，差异有统计学意义（P ＜0.05）；观察组腹痛、紫癜、关节疼痛消失时间均显著低于对照组
（P ＜0.05）；观察组不良反应总发生率为4.62%，显著低于对照组的16.36%（P ＜0.05）。结论：过敏性紫癜患者使用泼尼
松联合丹参注射液治疗，效果显著，可有效改善血清IL-23、IL-34与凝血因子水平，减少并发症，值得推广与应用。

Abstract:: Abstract: Objective To study curative efficacy of prednisone and salvia miltiorrhiza injection in treatment of allergic purpura
and its effectson serum interleukin 23 (IL-23) and interleukin 34 (IL-34) and coagulation factors. Methods 120 cases of
allergic purpura treated in our hospital from June 2015 to June 2018 were selected as subjects, the randomized table method was
divided into the observation group (n =65) and the control group (n =55). Prednisone was used in the control group, and danshen
injection was added to the observation group on the basis of the control group. The clinical efficacy, serum IL-23, IL-34, tumor
necrosis factor (TNF-α), activated partial thrombin time (APTT), prothrombin time (PT), fibrinogen (FIB), abdominal pain,
purpura, joint pain disappearance time and adverse reactions were compared between the two groups. Results After treatment,
the total effective rate in the observation group was higher than that in the control group (P ＜0.05). After treatment, serum IL-
23, IL-34 and TNF-α levels in both groups were significantly lower than those before treatment (P ＜0.05), and the observation
group were significantly lower than those in the control group (P ＜0.05). After treatment, APTT, PT and FIB levels in the two
groups were significantly improved compared with those before treatment (P＜0.05), APTT and PT levels in the observation group
were significantly higher than those in the control group, while FIB levels were lower than those in the control group (P＜0.05).
The time of abdominal pain, purpura and joint pain disappeared in the observation group was significantly lower than that in the
control group (P ＜0.05). The total incidence of adverse reactions in the observation group was 4.62%, significantly lower than
that in the control group (16.36%, P ＜0.05). Conclusion The application of prednisone combined with danshen injection in
patients with allergic purpura has a significant effect, which can effectively improve the serum IL-23, IL-34 and clotting factor
levels of patients, reduce complications, and is worthy of promotion and application.

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

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