CO<sub>2</sub>激光联合不同剂量干扰素治疗尖锐湿疣临床疗效研究<br />-《中国美容医学》

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Title:: Clinical Efficacy of CO₂ Laser Combined with Different Doses of Interferon in the Treatment of Condyloma Acuminatum

文章编号:: 1008-6455（2019）07-0051-04

作者:: 沈秀兰

Author(s):: SHEN Xiu-lan

关键词:: [关键词]CO₂激光; 干扰素; 给药剂量; 尖锐湿疣; 复发; 免疫细胞

Keywords:: Key words: carbon dioxide laser; interferon; administration doses; condyloma acuminata; recurrence; immune cell

分类号:: R752.5+3

文献标志码:: A

摘要:: [摘要]目的：探究二氧化碳（CO₂）激光联合不同剂量干扰素治疗尖锐湿疣（CA）的临床疗效。方法：回顾性分析82例行CO₂
激光治疗的CA患者临床资料，根据不同干扰素封闭注射给药剂量分为大剂量组（3×106IU/次，n =28）、小剂量组（1×106
IU/次，n =31）与对照组（未给予干扰素，n =23）。比较激光治疗前及治疗后4周，三组外周血免疫细胞分布[CD3+、CD4+/
CD8+、自然杀伤（NK）细胞]、白细胞介素[白细胞介素-2（IL-2）、白细胞介素-10（IL-10）、白细胞介素-12（IL-
12）]、功能性细胞因子[淋巴细胞趋化因子（LTN）、巨噬细胞移动抑制因子（MIF）、粒细胞-巨噬细胞集落刺激因子（GMCSF）]
水平变化，分析三组激光治疗后4周时治疗效果、激光治疗后3个月内复发率，及两组用药患者给药疗程内的药物不良
反应发生情况。结果：激光治疗后4周，三组外周血CD3+水平均较激光治疗前显著提升（P ＜0.05），但组间同一时间CD3+水
平比较均无统计学意义（P ＞0.05）；三组外周血CD4+/CD8+、NK细胞及血清IL-2、IL-12、LTN水平均较激光治疗前显著
提升，且同一时间比较大剂量组＞小剂量组＞对照组（P ＜0.05）；三组血清IL-10、MIF、GM-CSF水平均较激光治疗前
显著下降，其同一时间比较大剂量组＜小剂量组＜对照组（P ＜0.05）；大剂量组与小剂量组治疗有效率均明显高于对照
组（P ＜0.05）。激光治疗后3个月内，大剂量组与小剂量组复发率均明显低于对照组（P＜0.05）。给药疗程内，大剂量组
药物不良反应总发生率明显高于小剂量组（P ＜0.05）。结论：CO₂激光联合干扰素封闭注射治疗CA能取得较为理想的临床效
果，且疗效与复发率不受给药剂量影响，采取小剂量给药方案安全性更突出，有利于患者预后及康复。

Abstract:: Abstract: Objective To investigate the clinical effects of carbon dioxide (CO₂) laser combined with different doses of interferon
in the treatment of condyloma acuminatum (CA). Methods The clinical data of 82 patients with CA who underwent CO₂ laser
treatment were retrospectively analyzed. According to the different administration doses of interferon-blocked injection, the
patients were divided into high-dose group (3×106 IU/time, n =28) and low-dose group (1×106 IU/ time, n =31) and control group
(not given interferon, n =23). The levels of peripheral blood immune cell distribution [CD3+, CD4+/CD8+, natural killer (NK)
cells], interleukins [interleukin-2 (IL-2), interleukin-10 (IL-10), interleukin-12 (IL-12)] and functional cytokines [lymphocyte
chemotactic factor (LTN), macrophage migration inhibitory factor (MIF), granulocyte-macrophagocyte colony-stimulating
factor (GM-CSF)] were compared among the three groups before laser treatment and at 4 weeks after laser treatment. The
treatment effects at 4 weeks after laser treatment, the recurrence rate within 3 months after laser treatment, and the occurrence
of adverse drug reactions during the course of treatment were analyzed among the three groups. Results At 4 weeks after
laser treatment, the CD3+ level in peripheral blood in the three groups was significantly higher than that before laser treatment
(P ＜0.05), but there was no significant difference in CD3+ level between the groups at the same time (P ＞0.05). The levels of
peripheral blood CD4+/CD8+, NK cells and serum IL-2, IL-12 and LTN in the three groups were significantly higher than those
before laser treatment, and the levels at the same time showed high-dose group＞low-dose group＞control group (P ＜0.05).
The levels of serum IL-10, MIF and GM-CSF in the three groups were significantly lower than those before laser treatment,
and the levels at the same time showed high-dose group＜low-dose group＜control group (P ＜0.05). The effective rate of
treatment in high-dose group and low-dose group was significantly higher than that in control group (P ＜0.05). Within 3
months after laser treatment, the recurrence rate in high-dose group and low-dose group was significantly lower than that in
control group (P ＜0.05). Within course, the total incidence rate of adverse drug reactions in high-dose group was significantly
higher than that in low-dose group (P ＜0.05). Conclusion CO₂ laser combined with interferon-blocked injection for CA can
achieve ideal clinical effects, and its efficacy and recurrence rate are not affected by the doses. And low-dose regimen has more
prominent safety, and it is beneficial to the prognosis and rehabilitation.

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

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