[1]柳 芳,赵 宇,马 莉,等. 改良型PRF与普通型PRF在脂肪移植应用中的实验对比研究[J].中国美容医学,2019,(11):82-85.
　LIU Fang,ZHAO Yu,MA Li,et al. Application Comparison of A-PRF and PRF in Fat Transplantation[J].Medical Aesthetics and Beauty,2019,(11):82-85.
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 改良型PRF与普通型PRF在脂肪移植应用中的实验对比研究
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年11期
页码:
82-85
栏目:
出版日期:
2019-11-05

文章信息/Info

Title:
 Application Comparison of A-PRF and PRF in Fat Transplantation
文章编号:
1008-6455（2019）11-0082-04
作者:
 柳 芳; 赵 宇; 马 莉; 蒋思静; 吴亮亮; 贾大平
Author(s):
 LIU Fang; ZHAO Yu; MA Li; JIANG Si-jing; WU Liang-liang; JIA Da-ping
关键词:
 ; [关键词]A-PRF; PRF; 颗粒脂肪移植; 脂肪细胞成活率; VEGF; 细胞因子
Keywords:
 ; Key words: A-PRF;  PRF;  granular fat transplantation;  adipocyte survival rate;  VEGF;  cytokines
分类号:
R622
文献标志码:
A
摘要:
[摘要]目的：探索改良型富血小板纤维蛋白（advance platetel-rich fribin，A-PRF）与普通型富血小板纤维蛋白
(platetel-rich fribin，PRF)在脂肪移植中的应用效果，进而为临床应用提供指导。方法：将18只实验兔随机分成三组，
实验组（A-PRF组）：取兔背部脂肪组织，将2ml A-PRF+1ml颗粒脂肪移植到兔耳分离好的区域；阳性对照组（PRF组）：兔
耳移植区移入2ml PRF+1ml颗粒脂肪；阴性对照组（NS组）：兔耳移植区移入2ml生理盐水+1ml颗粒脂肪。分别于4周、8周、
12周取材进行大体观察、称重、HE染色与免疫染色来比较三组间脂肪成活差异。结果：各时间点，A-PRF组的脂肪存活率及
新生毛细血管密度明显优于其他两组，PRF组结果优于NS组，且三组间比较差异有统计学意义（P ＜0.05）。结论：A-PRF在
增加脂肪细胞成活率、减轻炎症反应及促进毛细血管新生方面优于普通型PRF，这为A-PRF的临床使用提供参考。

Abstract:
Abstract: Objective To explore the application of advanced platelet-rich fibrin (A-PRF) and common platelet-rich fibrin (PRF)
in fat transplantation in rabbit. Provide guidance for clinical applications. Methods Eighteen experimental rabbits were divided
into three groups randdomly. The experimental group(A-PRF group): adipose tissue was taken, and 2ml A-PRF+1ml granule
fat was transplanted into the isolated area of rabbit ears. The positive control group(PRF group): 2ml PRF+1ml granule fat was
transferred into the transplantation area. The negative control group(NS group): 2ml physiological saline +1ml granular fat was
transplanted. Gross observation, weighing, HE staining and immunostaining were performed at 4 weeks, 8 weeks, and 12 weeks
to compare the survival of fat between the three groups. Results At each observation time, the fat survival rate and neonatal
capillary density of the A-PRF group were significantly better than the other two groups. The positive control group was
superior to the negative control group, and the difference was statistically significant (P ＜0.05). Conclusion A-PRF is superior
to common PRF in increasing the survival rate of adipocytes, reducing inflammation and promoting capillary angiogenesis,
which provides a reference for the use of A-PRF in clinic.

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更新日期/Last Update: 2019-12-09