[1]林豪杰 综述,祁均梅 许 诺丁 明 陈 毓李雪囡 胡振林 审校. 成纤维细胞生长因子-5对毛囊周期的调控作用研究进展[J].中国美容医学,2019,(11):163-164.
　LIN Hao-jie,QI Jun-mei,XU Nuo,et al. Progress in the Regulation of FGF5 on Hair Follicle Cycle[J].Medical Aesthetics and Beauty,2019,(11):163-164.
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 成纤维细胞生长因子-5对毛囊周期的调控作用研究进展
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年11期
页码:
163-164
栏目:
出版日期:
2019-11-05

文章信息/Info

Title:
 Progress in the Regulation of FGF5 on Hair Follicle Cycle
文章编号:
1008-6455(2019)11-0163-04
作者:
 林豪杰1 综述; 祁均梅1 许 诺1丁 明2  陈 毓1李雪囡2 胡振林2  审校
Author(s):
 LIN Hao-jie1; QI Jun-mei1;  XU Nuo1; DING Ming2;  CHEN Yu1;  LI Xue-nan2;  HU Zhen-lin2
关键词:
 ; [关键词]毛囊; 毛囊周期; 成纤维细胞生长因子5; 脱发; 生发剂
Keywords:
 ; Key words: hair follicle;  hair follicle cycle;  fibroblast growth factor 5;  alopecia;  hair restorer
分类号:
R758.71
文献标志码:
A
摘要:
[摘要]毛囊是皮肤重要的附属器官，是毛发形成和生长的基础。毛囊具有周期性生长的特点，每个毛囊周期包括生长期、退
行期和休止期。毛囊周期由多种信号控制，成纤维细胞生长因子（Fibroblast Growth Factors, FGFs）家族的多个成员在
毛囊周期调节中起至关重要的作用，其中FGF5在毛囊周期的生长末期高表达，是结束毛囊生长期，推动其进入退行期的重要
因子，抑制FGF5的基因表达或拮抗其活性能够阻止毛囊进入退行期，延长毛囊生长期，起到促进毛发生长和防止脱发的作
用，因此，FGF5已成为育发防脱的重要靶标。

Abstract:
Abstract: Hair follicles form an important feature of the skin and are the basis for hair formation and growth. They are
characterized by periodic growth, and each follicular cycle consists of the growth phase, regression phase, and ambiguous
phase. A variety of signaling molecules are known to regulate the growth of hair follicles. Among these, members of the
Fibroblast Growth Factors (FGFs) family play a crucial role, in particular, FGF5, which is highly expressed at the end of the
growth phase, promoting the entry of the hair follicle into the regression phase. Thus, inhibiting the expression of FGF5 or
antagonizing its activity can prevent the hair follicles from entering the regression phase, prolonging the growth phase, and
consequently promoting hair growth and preventing hair loss. This review focuses on the regulation of hair follicle cycle by
FGF5.

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更新日期/Last Update: 2019-12-12