小剂量异维A酸联合2%超分子水杨酸治疗中重度痤疮疗效观察<br />-《中国美容医学》

文章信息/Info

Title:: Clinical Observation of Low-dose Isotretinoin Combined with 2% Supramolecular
Salicylic Acid in the Treatment of Moderate to Severe Acne

Author(s):: JIA Yu1; 2; GU Han-jiang1; LIU Ya-le1; CUI Xiao1; ZHANG Yi-tian1; ZENG Wei-hui1

Keywords:: Key words:isotretinoin; low-dose; supramolecular salicylic acid; moderatetosevereacne; effective rate

摘要:: [摘要]目的：探讨口服小剂量异维A酸联合外用2%超分子水杨酸治疗中重度痤疮的临床疗效。方法：共选取74例中重度痤疮
患者作为研究对象，口服小剂量异维A酸10mg，1次/d。治疗组：37例，联合外用2%新型超分子水杨酸治疗；对照组：
37例，联合外用夫西地酸乳膏及阿达帕林凝胶治疗。对两组患者治疗前后的皮损数量变化及治疗效果进行对比分析。结
果：经过8周的治疗，两组研究对象的总皮损数量较治疗前均显著减少（P ＜0.05）,且治疗组与对照组比较，无明显差
异（P ＞0.05）。针对不同类型的皮损，治疗组对粉刺的疗效比对照组更具优势，对丘疹与结节的疗效无明显差异。结论：
治疗中重度痤疮，小剂量异维A酸联合外用2%超分子水杨酸临床疗效较好，副作用小，可作为痤疮治疗的新选择。

Abstract:: Abstract: Objective Toobserve the clinical effi cacy of oral low-dose isotretinoin combined with 2% supramolecular salicylic
acid in the treatment of moderate and severe acne. Methods A total of 74 patients with moderate to severe acne were included
and treated with low-dose isotretinoin(10mg) daily. The treatment group was treated combined with 2% supramolecular
salicylic acid, while the control group was treated combined with fusidic acid cream and adapalene gel. The comparative
analyses,including the changes in the number of skin lesions and the treatment effect, were conductedbefore and after
treatment in the two groups of patients. Results After 8 weeks of treatment, the two groups showed signifi cant improvement
compared with thebaseline（P ＜0.05）, but there was no marked difference between the treatment group and the control
group （P ＞0.05）. For different types of skin lesions, the effect of the treatment group on acne is more advantageous than
the control group, and there is no signifi cant difference in the treatment effect on papules and nodules. Conclusion Low-dose
isotretinoincombined with 2% supramolecular salicylic acid is effective in the treatment of moderate to severe acneandhasminor
side effects, which is a new option for treatingacne.

[1] 徐晓静,朱元杰. 不同剂量异维A酸联合脉冲染料激光治疗酒渣鼻的疗效及安全性分析[J].中国美容医学,2021,(1):73.
　XU Xiao-jing,ZHU Yuan-jie. Efficacy and Safety of Different Doses of Isotretinoin Combined with Pulsed Dye Laserin the Treatment of Rosacea[J].Medical Aesthetics and Beauty,2021,(5):73.
[2] 夏卉,赵莉. 口服异维A酸联合光动力治疗重度痤疮疗效分析[J].中国美容医学,2021,(5):86.
　 XIA Hui,ZHAO Li. Analysis of Clinical Effect of Oral Isotretinoin Combined with Photodynamic Therapyon Severe Acne Patients[J].Medical Aesthetics and Beauty,2021,(5):86.