[1] 孟素玉,赵 鹏,马雅宁,等. 负压创面疗法对Ⅲ/Ⅳ度烧伤患者外周血内皮祖细胞循环数量的影响研究[J].中国美容医学,2020,(5):82-85.
　 MENG Su-yu,ZHAO Peng,MA Ya-ning,et al. Effect of Negative Pressure Wound Therapy on the Number of Peripheral BloodEndothelial Progenitor Cells in Patients with Ⅲ/Ⅳ Burn[J].Medical Aesthetics and Beauty,2020,(5):82-85.
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 负压创面疗法对Ⅲ/Ⅳ度烧伤患者外周血内皮祖细胞循环数量的影响研究
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年5期
页码:
82-85
栏目:
出版日期:
2020-05-10

文章信息/Info

Title:
 Effect of Negative Pressure Wound Therapy on the Number of Peripheral Blood
Endothelial Progenitor Cells in Patients with Ⅲ/Ⅳ Burn
文章编号:
1008-6455（2020）05-0082-04
作者:
 孟素玉; 赵 鹏; 马雅宁; 徐文虎
Author(s):
 MENG Su-yu; ZHAO Peng; MA Ya-ning; XU Wen-hu
关键词:
 [关键词]负压创面疗法; Ⅲ/Ⅳ度烧伤; 内皮祖细胞; 血管内皮生长因子; 基质细胞衍生因子; 肉芽组织
Keywords:
 Key words: negative pressure wound therapy（NPWT）;  Ⅲ/Ⅳ degree burn;  endothelial progenitor cells;  vascular endothelialgrowth factor;  stromal cell-derived factor;  granulation tissue
分类号:
R644
文献标志码:
A
摘要:
[摘要]目的：探讨负压创面疗法（Negative pressure wound therapy，NPWT）对于Ⅲ/Ⅳ度烧伤患者外周血内皮祖细胞
（Endothelial progenitor cells，EPCs）循环数量的影响。方法：本研究纳入了2017年3月-2019年3月在笔者医院烧伤科
接受治疗的Ⅲ/Ⅳ度烧伤患者130例，将患者随机分为观察组（n =65）和对照组（n =65），均接受常规治疗，观察组在此基础
上接受NPWT治疗，疗程为1周，比较两组患者治疗前后的外周血EPCs数量，并分析影响其变化的因素。结果：治疗后，观察
组的外周血EPCs数量明显增加[（85.3±18.1）×106 vs（34.1±12.5）×106]，差异有统计学意义（P ＜0.05）。而对照组
无明显变化[（45.2±19.4）×106 vs（34.7±16.8）×106]，差异无统计学意义（P ＞0.05）。此外，观察组的治疗后外周
血的血管内皮生长因子（Vascular endothelial growth factor，VEGF）水平和肉芽组织内的VEGF和基质细胞衍生因子-1α
（Stromal cell-derived factor-1α，SDF-1α）均显著增加（P ＜0.05），而对照组没有明显变化（P ＞0.05）。相关性
分析结果显示，外周血EPCs数量与外周血和肉芽组织内的VEGF和SDF-1α水平显著相关（P ＜0.05）。结论：NPWT可以增加
Ⅲ/Ⅳ度烧伤患者外周血EPCs数量，其机制可能与全身性和局部性的VEGF和SDF-1α水平上调相关。

Abstract:

Abstract: Objective The present study was designed to investigate the effect of negative pressure wound therapy (NPWT)
on the number of endothelial progenitor cells (EPCs) in patients with Ⅲ/Ⅳ burns. Methods A total of 130 patients with
grade Ⅲ/Ⅳ burns who were treated in the burn department of our hospital from March 2017 to March 2019 were enrolled.
The patients were randomly divided into the observation group (n =65) and the control group (n = 65). All patients received
the routine treatment. In addition, the patients in the observation group received NPWT treatment in addition to the routine
treatment. The course of treatment was one week. The number of peripheral blood EPCs before and after treatment in the two
groups were compared, and the factors affecting the changes were analyzed. Results After treatment, the number of EPCs in
the peripheral blood of the observation group were increased signifi cantly [(85.3±18.1)×106 vs (34.1±12.5)×106], the difference
was statistically signifi cant(P ＜0.05). While the control group had no signifi cant change [(45.2±19.4)×106 vs (34.7±16.8)×106,
P ＞0.05]. In addition, the levels of vascular endothelial growth factor (VEGF) in peripheral blood and VEGF and stromal cellderived
factor-1α (SDF-1α) in granulation tissue were significantly increased in the observation group(P ＜0.05), while the
control group did not have signifi cant change(P ＞0.05). Correlation analysis showed that the number of peripheral blood EPCs
was signifi cantly correlated with VEGF and SDF-1α levels in peripheral blood and granulation tissue (P ＜0.05). Conclusion
NPWT can increase the number of EPCs in peripheral blood of patients with Ⅲ/Ⅳ burns. The mechanism may be related to the
up-regulation of systemic and local VEGF and SDF-1α levels.
更新日期/Last Update: 2020-05-29