Q开关激光治疗咖啡斑的回顾性分析<br />-《中国美容医学》

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Title:: Retrospective Analysis of the Treatment of Café-au-lait-macules by Q - Switch Laser

文章编号:: 1008-6455（2020）07-0025-04

作者:: 陈文静; 向芳; 李子君

Author(s):: CHEN Wen-jing; XIANG Fang; LI Zi-jun

关键词:: [关键词]咖啡斑; Q 开关532nm 激光; Q开关755nm 激光; 不良反应

Keywords:: Key words: Cafe-au-lait- macules ; Q-switched 532 nm laser; Q-switched 755 nm laser; treatment; clinical effi cacy; adverse reactions

分类号:: R758.5+1

文献标志码:: A

摘要:: [摘要]目的：评估Q开关激光治疗咖啡斑的疗效及相关影响因素。方法：将2010年1月-2018年1月笔者科室门诊接受Q开关激
光治疗的资料完整的66例咖啡斑患者随机分为QS-532组(32例)和QS-755组(34例)。QS-532组采用Q开关532nm激光治疗，QS-
755组采用Q开关755nm激光治疗。每3个月治疗1次，对比治疗后6个月、9个月和12个月时的临床疗效。QS-755组再根据患者年
龄、性别、部位、咖啡斑颜色、形状、边缘情况、面积进行分组，比较治疗前后的临床变化，观察激光治疗的不良反应。结
果：随访至初次治疗后12个月，QS-755组的有效率和痊愈率分别为73.5%和41.2%，高于QS-532组的46.9%和28.1% (P ＜0.05)。
根据咖啡斑的颜色分析，浅褐色(χ2＝12.628，P ＜0.05)及中褐色(χ2＝11.972，P＜0.05)的咖啡斑临床疗效均优于深褐色咖啡
斑，而浅褐色与中褐色咖啡斑的临床疗效差异无统计学意义(χ2=0.922，P＞0.05)；根据咖啡斑形状的情况分析，形状不规则
的有效率明显高于形状规则的咖啡斑(χ2＝12.871，P＜0.05)；根据咖啡斑边缘的情况，边缘不光滑的咖啡斑有效率明显高于
边缘光滑的咖啡斑(χ2＝10.557，P＜0.05)；不同面积的咖啡斑治疗效果差异无统计学意义(χ2=0.172，P＞0.05)；不同性别患
者治疗效果的差异无统计学意义(χ2=0.156，P ＞0.05)；不同年龄阶段接受治疗的临床疗效差异无统计学意义(χ2=0.189，
P ＞0.05)；不同部位咖啡斑治疗的临床疗效差异无统计学意义(χ2=0.137，P＞0.05)。治疗过程中除疼痛外未发生其他不良反
应。结论：Q开关755nm激光是治疗咖啡斑的一种安全有效的方法，其疗效受咖啡斑颜色、形状及边缘情况的影响。

Abstract:: Abstract:Objective To evaluate the curative effect and the influencing factors of Q-switch laser treatment in Café-au-laitmacules（
CALMs）. Methods 66 patients of CALMs accepted Q-switch laser treatment ,adopted by dermatology clinic in
Xinjiang Uygur Autonomous Region People’s Hospital, were divided in 2 groups, QS-532 (32 cases) accepted Q-switch laser
treatment of 532nm and QS-755 (34 cases) accepted Q-switch laser treatment of 755nm. Both of them were accepted by the
Q-switch laser treatment every three months. The clinical effi cacy was compared at 6, 9 and 12 months after treatment. Group
QS-755 were further divided into groups according to age, gender,location,color,shape,edge and area.The clinical changes
before and after treatment were compared.The adverse reactions of laser therapy were observed. Results Following-up for
12 months after the fi rst treatment, the effective rate and cure rate of QS-755 were 73.5% and 41.2%,higher than QS-532 of
46.9% and 28.1%(P ＜0.05).According to color analysis of CALMs, the clinical effects of sandy beige(χ2=12.628,P ＜0.05)
and toffee(χ2＝11.972,P ＜0.05) were superior to puce CALMs, while, there was no statistical significance(χ2=0.922,P ＞
0.05) between sandy beige and toffee in the clinical effects. According to form analysis,the clinical effects of irregular ones
were apparently better than regular ones(χ2＝12.871,P ＜0.05).According to border analysis,the clinical effects of unsmooth
ones had advantages over smooth ones(χ2＝10.557,P ＜0.05).However,There was no signifi cant difference in the therapeutic
effect between the different gender(χ2=0.156,P ＞0.05). There was no significant difference in the therapeutic
effect between the different area(χ2=0.172,P ＞0.05).There was no statistical significance in the clinical effects
in different ages(χ2=0.189,P ＞0.05). There was no significant difference in the therapeutic effect between the different
location(χ2=0.137,P ＞0.05).Besides, there was no side effect other than a little pain in the treatment. Conclusion Q-switch
laser treatment of 755 nm is a safe and effective method to treat CALMs, depending on the color, border and form.

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

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