[1] 施跃先,肖 丽,任 慧君,等. 金菊解毒颗粒联合艾拉光动力治疗中重度痤疮患者的疗效及安全性评价[J].中国美容医学,2020,(7):101-104.
　 SHI Yue-xian,XIAO Li,REN Hui-jun,et al. Effi cacy and Safety of Jinju Jiedu Granules Combined with ALA-PDT on Patients withModerate to Severe Acne[J].Medical Aesthetics and Beauty,2020,(7):101-104.
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 金菊解毒颗粒联合艾拉光动力治疗中重度痤疮患者的疗效及安全性评价
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年7期
页码:
101-104
栏目:
出版日期:
2020-07-10

文章信息/Info

Title:
 Effi cacy and Safety of Jinju Jiedu Granules Combined with ALA-PDT on Patients with
Moderate to Severe Acne
文章编号:
1008-6455（2020）07-0101-04
作者:
 施跃先1; 肖 丽2; 任 慧君1; 李 莉1; 李 茜1; 向琼瑶1
Author(s):
 SHI Yue-xian1;  XIAO Li2;  REN Hui-jun1; LI Li1;  LI Qian1; XIANG Qiong-yao1
关键词:
 [关键词]金菊解毒颗粒; 艾拉光动力; 痤疮; 皮损数量; 美观度
Keywords:
 Key words: Jinju Jiedu Granules;  ALA-PDT;  acne;  quantities of skin lesions;  aesthetic degree
分类号:
R758.73+3
文献标志码:
A
摘要:
[摘要]目的：探讨金菊解毒颗粒与艾拉光动力联合治疗中重度痤疮的疗效及对皮损症状及美观度的影响。方法：选取2017年
12月-2019年5月于笔者医院治疗的120例中、重度痤疮患者，按随机数表法分为观察组与对照组，每组60例；对照组患者给
予艾拉光动力治疗，观察组在对照组基础上给予金菊解毒颗粒联合治疗，两组患者治疗时间均为1个月，治疗后3个月随访，
随访评估内容为患者皮肤状况及不良反应情况。比较治疗前及治疗后3个月时两组患者治疗有效率、皮损数量、美观度、不
良反应发生率以及痤疮复发状况。结果：观察组治疗有效率显著高于对照组（P ＜0.05）；治疗后3个月，两组患者粉刺、丘
疹、脓疱及结节数量均显著少于治疗前（P ＜0.05），且观察组治疗后皮损数量与对照组比较有显著性差异（P ＜0.05）；治
疗后3个月，两组患者皮肤角质层含水量均显著升高（P ＜0.05），黑色素含量、血红素含量均显著下降（P ＜0.05），但观
察组治疗后升高/下降与对照组比较无显著性差异（P ＞0.05）；治疗期间，观察组与对照组不良反应发生率分别为25.00%和
31.00%（P ＞0.05）；观察组患者痤疮复发率略低于对照组（P ＞0.05）。 结论：金菊解毒颗粒联合艾拉光动力治疗中重度
痤疮临床疗效显著，可改善其皮损症状，恢复美观，复发风险较低，且疗法安全性较理想，对患者预后恢复有利。

Abstract:
Abstract: Objective To study the effi cacy of Jinju Jiedu granules and ALA-PDT (5-aminolevulinic acid photodynamic therapy)
on patients with moderate-to-severe acne, and its effects on symptoms of skin lesions and aesthetic degree. Methods A total
of 120 patients with moderate-to-severe acne treated in our hospital from December 2017 to May 2019 were selected for the
study.They were randomly divided into observation group and control group, with 60 cases in each group. Both groups were
given routine treatment, and on this basis, control group was given ALA-PDT while observation group was given Jinju Jiedu
granules combined with ALA-PDT, and the two groups were treated for 1 month and followed up for 3 months. The effective
rate of treatment, quantities of skin lesions, aesthetic degree, incidence rates of adverse reactions and recurrence of acne were
compared between the two groups. Results The effective rate of treatment in observation group was signifi cantly higher than
that in control group (P ＜0.05). After treatment,the quantities of pimple, papules, pustules and nodules in the two groups were
significantly less than those before treatment (P ＜0.05), and the quantities of skin lesions in observation group after
treatment were signifi cantly different from those in control group (P ＜0.05). After treatment, the water content of stratum
corneum in the two groups was significantly increased (P ＜0.05) while the melanin content and heme content were
signifi cantly decreased (P ＜0.05). However,there were no signifi cant differences in the increase/decreases between observation
group and control group after treatment (P ＞0.05). During treatment, the incidence rates of adverse reactions in observation
group and control group were 25.00% and 31.00% respectively (P ＞0.05). The recurrence rate of acne in observation group was
slightly lower than that in control group (P ＞0.05). Conclusion Jinju Jiedu granules combined with ALA-PDT has signifi cant
clinical efficacy in the treatment of moderate-to-severe acne. It can improve the symptoms of skin lesions, and restore the
aesthetics, and it has low risk of recurrence and ideal safety of therapy, and it can help the prognosis and recovery of patients.
更新日期/Last Update: 2020-07-22