[1] 李 伶,衡 鲲,郭中华,等. Q开关Nd:YAG倍频532nm激光联合光子嫩肤治疗面部雀斑疗效分析[J].中国美容医学,2020,(9):41-45.
　 LI Ling,HENG Kun,GUO Zhong-hua,et al. Efficacy of Q-switched Nd:YAG Frequency Doubling 532nm Laser Combined withPhotorejuvenation on Freckles[J].Medical Aesthetics and Beauty,2020,(9):41-45.
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 Q开关Nd:YAG倍频532nm激光联合光子嫩肤治疗面部雀斑疗效分析
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年9期
页码:
41-45
栏目:
出版日期:
2020-09-10

文章信息/Info

Title:
 Efficacy of Q-switched Nd:YAG Frequency Doubling 532nm Laser Combined with
Photorejuvenation on Freckles
文章编号:
1008-6455(2020)09-0041-05
作者:
 李 伶1; 衡 鲲2; 郭中华1; 李 雪1
Author(s):
 LI Ling1;  HENG Kun2;  GUO Zhong-hua1; LI Xue1
关键词:
 [关键词]雀斑; Q开关Nd:YAG倍频532nm激光; 光子嫩肤技术; 疗效
分类号:
R758.4+3
文献标志码:
A
摘要:
[摘要]目的：探讨Q开关Nd:YAG倍频532nm激光联合光子嫩肤治疗雀斑的疗效。方法：选取186例面部雀斑患者，随机分为观
察组、对照1组和对照2组，每组62例，对照1组给予Q开关Nd:YAG倍频532nm激光治疗，对照2组给予光子嫩肤技术治疗，观察
组给予Q开关Nd:YAG倍频532nm激光联合光子嫩肤治疗，评定三组外观疗效，对比治疗前后的VISIA皮肤图像指标、皮肤性状
和血清内皮素1(ET-1)和血管内皮生长因子(VEGF)水平变化，对三组患者进行为期6个月的随访观察，记录原皮损处雀斑复发
病例。结果：观察组的临床总有效率显著高于两对照组(P ＜0.05)，对照1组显著高于对照2组(P ＜0.05)；治疗后，三组的
VISIA皮肤图像指标中色素斑、皱纹、纹理、毛孔及紫质沉淀共5项评分和皮肤性状指标中皮肤色泽、皮损及均一性评分均显
著降低(P ＜0.05)，三组的血清ET-1水平显著降低(P ＜0.05)，VEGF水平显著升高(P ＜0.05)，以上指标对比，三组间治疗后
比较，差异均具有统计学意义(P ＜0.05)，观察组显著高于两对照组，对照1组显著低于对照2组(P ＜0.05)；观察组、对照1
组及对照2组的原皮损处雀斑复发率分别为1.61%、12.90%及16.13%，三组间对比差异有统计学意义(P ＜0.05)，观察组的复
发率显著低于两对照组(P ＜0.05)。结论：Q开关Nd:YAG倍频532 nm激光联合光子嫩肤治疗能明显消除雀斑，改善患者肤质，
且能有效减轻术后炎性色素沉淀，提高临床疗效，降低雀斑复发率。

Abstract:
Abstract: Objective To explore the efficacy of Q-switched Nd:YAG frequency doubling 532nm laser combined with
photorejuvenation on freckles. Methods A total of 186 patients with facial freckles were randomly divided into observation
group, control group 1 and control group 2, with 62 cases in each group. Control group 1 was given Q-switched Nd:YAG
frequency doubling 532nm laser, and control group 2 was given photorejuvenation, and observation group was given Q-switched
Nd:YAG frequency doubling 532nm laser combined with photorejuvenation. The appearance efficacy was evaluated in the two
groups. The VISIA skin image indicators, skin traits and levels of serum endothelin-1 (ET-1) and vascular endothelial growth
factor (VEGF) were compared before and after treatment. The patients in the three groups were given 6 months of follow-up
observation, and the recurrence of freckles at the original skin lesions was recorded. Results The total clinical effective rate in
observation group was significantly higher than that in control groups 1 and 2 (P ＜0.05), and the rate in control group 1 was
significantly higher than that in control group 2 (P ＜0.05). After treatment, the scores of 5 items of pigment spots, wrinkles,
texture, pores and purple deposits of VISIA skin image indicators and scores of skin traits indicators of skin color, skin lesions
and homogeneity were significantly decreased among the three groups (P ＜0.05), and the serum ET-1 level in the three groups
was significantly decreased (P ＜0.05) while the VEGF level was significantly increased (P ＜0.05), and there were statistically
significant differences in the above indexes among the three groups (P ＜0.05), and the levels in observation group were
significantly higher than those in control groups 1 and 2, and the levels in control group 1 were significantly lower than those
in control group 2 (P ＜0.05). The recurrence rates of freckles at the original skin lesions in observation group, control group 1
and control group 2 were 1.61%, 12.90% and 16.13% respectively (P ＜0.05), and the recurrence rate in observation group was
significantly lower than that in control group 1 and control group 2 (P ＜0.05). Conclusion Q-switched Nd:YAG frequency
doubling 532nm laser combined with photorejuvenation can significantly eliminate freckles, improve the skin type of patients,
and effectively reduce postoperative inflammatory reaction pigmentation, improve clinical efficacy and reduce recurrence rate
of freckles.

相似文献/References:

[1] 魏 瑾,唐先发,杨振海,等. 我国北方四省市306例雀斑患者临床流行病学分析[J].中国美容医学,2020,(7):43.
　[J].Medical Aesthetics and Beauty,2020,(9):43.
[2] 李康东,陈 滨. 光子嫩肤联合芦荟凝胶治疗雀斑的疗效及患者术后自我认同评价分析[J].中国美容医学,2021,(3):34.
　LI Kang-dong,CHEN Bin. Effect of Photonrejuvenation Combined with Aloe Vera Gel on Freckles andEvaluation of Self-identity of Patients after Surgery[J].Medical Aesthetics and Beauty,2021,(9):34.

更新日期/Last Update: 2020-09-25