[1] 崔 乐,畅晓元,许 静. 特应性皮炎患者外周血Th17/Treg和IL-17、TGF-β的表达及与病情相关性研究[J].中国美容医学,2021,(1):89-91.
　 CUI Le,CHANG Xiao-yuan,XU Jing. Expression of Th17 / Treg, IL-17 and TGF-β in Peripheral Blood of Patients with AtopicDermatitis and Correlation with the Disease[J].Medical Aesthetics and Beauty,2021,(1):89-91.
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 特应性皮炎患者外周血Th17/Treg和IL-17、TGF-β的表达及与病情相关
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年1期
页码:
89-91
栏目:
出版日期:
2021-01-10

文章信息/Info

Title:
 Expression of Th17 / Treg, IL-17 and TGF-β in Peripheral Blood of Patients with Atopic
Dermatitis and Correlation with the Disease
文章编号:
1008-6455（2021）01-0089-04
作者:
 崔 乐1; 畅晓元1; 许 静2
Author(s):
 CUI Le1; CHANG Xiao-yuan1; XU Jing2
关键词:
 [关键词]特应性皮炎; 辅助性T细胞17; 调节性T细胞; 白细胞介素-17; 转化生长因子-β
Keywords:
 Key words: atopic dermatitis;  Th17;  Treg;  IL-17;  TGF-β
分类号:
R758.22
文献标志码:
A
摘要:
[摘要]目的：探讨特应性皮炎（Atopic dermatitis，AD）患者外周血辅助性T细胞17（Th17）/调节性T细胞（Treg）平衡
和白细胞介素-17（IL-17）、转化生长因子-β（TGF-β）的表达水平，并分析其与病情的相关性。方法：选取2015年3
月-2019年6月在笔者医院确诊的AD患者126例作为观察组，再选取同期健康体检者60例作为对照组。分别检测两组静脉血
中Th17、Treg细胞的百分比含量和IL-17、TGF-β水平。采用欧洲特应性皮炎评分标准（Scoring atopic dermatitis，
SCORAD）对观察组病情进行评分，并分为以下三个亚组：轻度组（50例），中度组（42例），重度组（34例）。结果：观
察组外周血中Th17、Th17/Treg和IL-17水平均高于对照组，Treg水平低于对照组，差异有统计学意义（P ＜0.05）。与对照
组比较，观察组TGF-β水平降低，但差异无统计学意义（P ＞0.05）。重度组、中度组外周血中Th17、Th17/Treg和IL-17水
平均高于轻度组，Treg、TGF-β水平均低于轻度组，差异有统计学意义（P ＜0.05）。重度组外周血中Th17、Th17/Treg和
IL-17水平均高于中度组，Treg、TGF-β水平低于中度组，差异有统计学意义（P ＜0.05）。Pearson 相关分析显示，患者外
周血Th17/Treg、IL-17水平与其病情（SCORAD评分）之间呈正相关（r =0.930，0.893，P ＜0.001）。患者TGF-β水平与其病
情（SCORAD评分）之间呈负相关（r =-0.912，P ＜0.001）。结论：AD患者外周血中Th17、Th17/Treg和IL-17水平均升高，
Treg、TGF-β水平均降低，且患者Th17/Treg、IL-17、TGF-β水平均与其病情程度密切相关。因此，Th17/Treg细胞平衡在
AD发病机制中发挥重要作用，在今后临床上可据此给予对应治疗。

Abstract:
Abstract: Objective To explore the balance of peripheral blood T helper cell 17 (Th17)/T regulatory cells (Treg) and
interleukin-17 (IL-17) and transforming growth factor-β (TGF-β) in patients with atopic dermatitis (AD) expression level, and
analyze their correlation with the condition. Methods 126 patients of AD diagnosed in our hospital from March 2015 to June
2019 were selected as the observation group, and 60 healthy medical examinees during the same period were selected as the
control group. The percentage of Th17 and Treg cells and the levels of IL-17 and TGF-β in the venous blood of the two groups
were detectedrespectively. The observation group was scored using the European scoring atopic dermatitis (SCORAD) and
divided into the following three subgroups: the mild group (n =50), the moderate group (n =42), and the severe group (n =34).
Results The levels of Th17, Th17/Treg and IL-17 in the peripheral blood of the observation group were higher than those of
the control group, and the levels of Treg were lower than that of the control group, the differences were statistically significant
(P ＜0.05). Compared with the control group, the TGF-β level of the observation group decreased, but there was no significant
difference (P ＞0.05). The levels of Th17, Th17/Treg and IL-17 in peripheral blood of the severe group and the moderate
group were higher than those of the mild group, while the levels of Treg and TGF-β were lower than those of the mild
group (P ＜0.05). The levels of Th17, Th17/Treg and IL-17 in the peripheral blood of the severe group were higher than those
of the moderate group, and the levels of Treg and TGF-β were lower than those of the moderate group (P ＜0.05). Pearson
correlation analysis showed that the Th17/Treg and IL-17 levels in patients’ peripheral blood were positively correlated with
their condition (SCORAD) (r =0.930, 0.893, P ＜0.001). There wasthe negativecorrelation betweenthe TGF-β level andpatient’s
condition (SCORAD) (r =-0.912, P ＜0.001). Conclusion The levels of Th17, Th17/Treg and IL-17 in peripheral blood of AD
patients increased, while the levels of Treg and TGF-β decreased. And the levels of Th17/Treg, IL-17, and TGF-β in patients are
closely related to their condition. Therefore, Th17/Treg cell balance plays an important role in the pathogenesis of AD, and can
be treated accordingly in the future in the clinic.

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更新日期/Last Update: 2021-02-02