[1] 程 芳,郭 勇,彭 健. 非剥脱性点阵CO2激光联合氢醌乳膏治疗黄褐斑的临床疗效及安全性分析[J].中国美容医学,2021,(4):45-48.
　 CHENG Fang,GUO Yong,PENG Jian. Clinical Efficacy and Safety Analysis of Non-ablative Fractional CO2 Laser Combinedwith Hydroquinone Cream in the Treatment of Melasma[J].Medical Aesthetics and Beauty,2021,(4):45-48.
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 非剥脱性点阵CO2激光联合氢醌乳膏治疗黄褐斑的临床疗效及安全性分析
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年4期
页码:
45-48
栏目:
出版日期:
2021-04-10

文章信息/Info

Title:
 Clinical Efficacy and Safety Analysis of Non-ablative Fractional CO2 Laser Combined
with Hydroquinone Cream in the Treatment of Melasma
文章编号:
1008-6455（2021）04-0045-04
作者:
 程 芳1; 郭 勇1; 彭 健2
Author(s):
 CHENG Fang1;  GUO Yong1;  PENG Jian2
关键词:
 [关键词]非剥脱性点阵CO2激光; 氢醌; 黄褐斑; 疗效; 安全性
Keywords:
 Key words:non-ablative fractional CO2 laser; hydroquinone cream;  melasma;  efficacy;  safety
分类号:
R758.4+2
文献标志码:
A
摘要:
[摘要]目的：对比非剥脱性点阵CO2激光联合氢醌乳膏与氢醌乳膏单用治疗黄褐斑的临床疗效及安全性。方法：收集笔者医
院2017年1月-2019年1月诊治的60例女性黄褐斑患者，采用自体对照策略，左面颊为对照组，右面颊为观察组。对照组：
仅给予氢醌乳膏外用；观察组：给予氢醌乳膏联用非剥脱性点阵CO2激光。治疗6周，随访至第18周。评估并记录各时间点
皮损黑暗度、均匀性、皮损改善程度、治疗满意度及治疗相关不良事件等。对所有数据进行统计学分析。结果：对照组自
第6周起黑暗度及均匀性评分均明显较治疗前降低（P ＜0.05），观察组自第3周起黑暗度及均匀性评分均明显较治疗前降
低（P ＜0.05）。观察组第3、6、10、18周黑暗度及均匀性评分均低于对照组，差异均具有统计学意义（均P ＜0.05）。对照
组治疗后皮损改善程度以轻度改善及中度改善为主，观察组治疗后皮损改善程度以中度改善及明显改善为主，两组治疗后皮
损改善程度比较有显著性差异（P ＜0.05）。观察组治疗满意度评分高于对照组，差异具有统计学意义（P ＜0.05）。两组间
红斑、水疱、瘙痒、疼痛、脱屑、色素减退及色素沉着等治疗相关不良事件发生率比较均无统计学差异（均P ＜0.05）。结
论：相比于氢醌乳膏单用，非剥脱性点阵CO2激光联用氢醌乳膏可更有效改善黄褐斑皮损，患者满意度更高，但治疗相关不
良事件发生率并未增加。

Abstract:
Abstract:Objective To compare the clinical efficacy and safety of non-ablative fractional CO2 laser combined with
hydroquinone cream and hydroquinone cream in the treatment of melasma. Methods 60 melasma patients, treated in our
hospital from January 2017 to January 2019, were collected. The self-control strategy was adopted. The left cheek was taken
as control group, while the right cheek was taken as observation group. Control group: hydroquinone cream was applied.
Observation group: hydroquinone cream combined with non-ablative fractional CO2 laser were applied. All treatment was given
for 6 weeks, and follow-up was performed to the 18th weeks. The darkness, uniformity, improvement of skin lesions, treatment
satisfaction and treatment-related adverse events were evaluated and recorded. Statistical analysis was performed. Results
Since the 6th week, the darkness and uniformity scores were lower than that before treatment in control group (P ＜0.05).
Since the 3rd week, the darkness and uniformity scores were lower than that before treatment in observation group (P＜0.05). The
darkness and uniformity scores of the observation group at the 3rd, 6th, 10th, and 18th were significantly lower than those of control
group (P＜0.05). The degree of skin lesion improvement was mainly mild and moderate in control group, while it was
mainly moderate and obvious in the observation group, and there was a significant difference in the degree of skin lesion
improvement between two groups (P ＜0.05). The treatment satisfaction score of observation group was higher than that of
control group (P ＜0.05). There were no significant differences in the incidence of treatment-related adverse events (erythema,
blistering, itching, pain, desquamation, hypopigmentation and pigmentation) between two groups (P ＜0.05). Conclusion
Compared with hydroquinone cream, the combination strategy of non-ablative fractional CO2 laser and hydroquinone cream can
more effectively improve melasma lesion, achieving high treatment satisfaction without increasing the incidence of treatmentrelated
adverse events.
更新日期/Last Update: 2021-05-11