[1] 郑 旭,高建明,黄 静. 他克莫司联合地奈德乳膏对化妆品接触性皮炎的效果评价及对血清IgE、TGF-β及IL-10水平的影响[J].中国美容医学,2021,(6):68-71.
　 ZHENG Xu,GAO Jian-ming,HUANG Jing. Evaluation of the Effect of Tacrolimus Combined with Deneride Cream on CosmeticDermatitis and Its Effect on Serum IgE, TGF-β and IL-10 Levels[J].Medical Aesthetics and Beauty,2021,(6):68-71.
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 他克莫司联合地奈德乳膏对化妆品接触性皮炎的效果评价及对血清IgE、
TGF-β及IL-10水平的影响
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年6期
页码:
68-71
栏目:
出版日期:
2021-06-10

文章信息/Info

Title:
 Evaluation of the Effect of Tacrolimus Combined with Deneride Cream on Cosmetic
Dermatitis and Its Effect on Serum IgE, TGF-β and IL-10 Levels
作者:
 郑 旭; 高建明; 黄 静
Author(s):
 ZHENG Xu; GAO Jian-ming; HUANG Jing
关键词:
 [关键词]化妆品皮炎; 他克莫司; 地奈德乳膏; 血清免疫球蛋白E; 转化生长因子β; 白细胞介素-10
Keywords:
 Key words: cosmetic dermatitis;  tacrolimus;  dinaide cream;  serum immunoglobulin e;  transforming growth factor beta; interleukin-10
文献标志码:
A
摘要:
[摘要]目的：观察在化妆品接触性皮炎患者中应用他克莫司联合地奈德乳膏的疗效及对患者血清免疫球蛋白E（IgE）、转化
生长因子β（TGF-β）、白细胞介素-10（IL-10）的影响。方法：选择2016年1月-2019年12月笔者医院收治的80例化妆品接
触性皮炎患者为研究对象，随机数字表法分为对照组（40例）与联合组（40例）。对照组应用地奈德乳膏治疗，联合组在对
照组基础上应用他克莫司治疗。比较两组的症状评分、临床疗效及血清IgE、TGF-β、IL-10水平变化，比较两组的不
良反应发生情况。结果：联合组的症状评分低于对照组，差异有统计学意义（P ＜0.05）；联合组临床有效率高于对照
组，差异有统计学意义（P ＜0.05）；治疗后，两组的IgE水平均低于治疗前（P ＜0.05），TGF-β和IL-10水平均高于
治疗前（P ＜0.05），与对照组比较，联合组的IgE水平更低（P＜0.05），TGF-β和IL-10水平更高（P＜0.05）；两组的不
良反应发生率比较，差异无统计学意义（P ＞0.05）。结论：对化妆品接触性皮炎患者应用他克莫司联合地奈德乳膏疗效确
切，能够减轻皮肤炎症，降低过敏反应，且安全可靠。
Abstract:
Abstract: Objective To observe the therapeutic effect of tacrolimus combined with dinaide cream on patients with cosmetic
dermatitis and its effects on serum immunoglobulin E(IgE), transforming growth factor β(TGF-β), interleukin-10(IL-10)
Impact. Methods Using random number method, 80 cases of cosmetic dermatitis treated in our hospital from January 2016 to
December 2019 were divided into the control group(40 cases) and the combined group(40 cases). The control group was treated
with dinaide cream, and the combination group was combined with tacrolimus on the basis of the control group. Symptom
scores, clinical effects, and changes in serum IgE, TGF-β, and IL-10 levels were compared between the two groups, and adverse
events were compared between the two groups. Results The symptom score of the combined group was lower than that of the
control group, and the difference was statistically significant(P ＜0.05), the clinical effective rate of the combined group was
higher than that of the control group, and the difference was statistically significant(P ＜0.05), the IgE levels of the two groups
after treatment, the levels of TGF-β and IL-10 were lower than those before treatment(P ＜0.05), and the levels of TGF-β and
IL-10 were higher than those before treatment(P ＜0.05). Compared with the control group, the IgE level of the combined group
was lower(P ＜0.05), and TGF-β And IL-10 levels were higher(P ＜0.05), there was no significant difference in the incidence
of adverse reactions between the two groups(P ＞0.05). Conclusion Applying tacrolimus and dinaide cream to patients with
cosmetic dermatitis is effective, can reduce skin inflammation and reduce allergic reactions, and has a high cure rate and is safe
and reliable.

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更新日期/Last Update: 2021-07-09