[1] 周 玲,杨 云,吴 雨,等. 点阵CO2激光联合积雪苷霜软膏治疗瘢痕疙瘩临床分析[J].中国美容医学,2021,(6):90-94.
　 ZHOU Ling,YANG Yun,WU Yu,et al. Clinical Observation of CO2 Dot Array Laser Combined with Centella TriterpenesCream in Treating Keloid[J].Medical Aesthetics and Beauty,2021,(6):90-94.
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 点阵CO2激光联合积雪苷霜软膏治疗瘢痕疙瘩临床分析
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年6期
页码:
90-94
栏目:
出版日期:
2021-06-10

文章信息/Info

Title:
 Clinical Observation of CO2 Dot Array Laser Combined with Centella Triterpenes
Cream in Treating Keloid
文章编号:
1008-6455(2021)06-0090-04
作者:
 周 玲1; 杨 云1; 吴 雨1; 雷淑英1; 陈昌望2
Author(s):
 ZHOU Ling1; YANG Yun1;  WU Yu1; LEI Shu-ying1; CHEN Chang-wang2
关键词:
 [关键词]点阵CO2激光; 积雪草; 瘢痕疙瘩; 疗效; 胶原纤维
Keywords:
 Key words: fractional CO2 laser; centellaasiatica;  keloids;  efficacy;  collagen fiber
分类号:
R619+.6
文献标志码:
A
摘要:
[摘要]目的：探讨点阵CO2激光联合积雪苷霜软膏对瘢痕疙瘩改善程度、胶原纤维及热休克蛋白47的影响。方法：选取2017
年1月-2019年1月笔者医院收治的60例瘢痕疙瘩患者，采用随机数字表法分为实验组（n =31）和对照组（n =29）。对照组采
用点阵CO2激光治疗，实验组在对照组的基础上给予积雪苷霜软膏治疗。对比两组患者在治疗前和治疗第1个、第2个疗程时
瘢痕疙瘩改善程度、胶原纤维及热休克蛋白47的水平。对比两组患者治疗后临床疗效和不良反应。结果：治疗后，实验组在
第1个疗程和第2个疗程VSS评分显著低于对照组（P ＜0.05）；实验组在第1个疗程和第2个疗程总胶原像素面积差显著低于
对照组（P ＜0.05）；实验组在第1个疗程和第2个疗程热休克蛋白47显著低于对照组，差异具有统计学意义（P ＜0.05）；
治疗后，实验组总有效率74.19%，显著高于对照组的48.27%（P ＜0.05）；实验组不良反应发生率35.48%，显著低于对照组的
65.51%，差异具有统计学意义（P ＞0.05）。结论：点阵CO2激光联合积雪苷霜软膏可有效改善患者的瘢痕、胶原纤维和热休克
蛋白47，疗效较好，能降低不良反应发生率。

Abstract:
Abstract: Objective To study the effects of fractional CO2 laser combined with Centella asiatica on keloids improvement,
collagen fibers and heat shock protein 47. Methods Sixty patients with keloid admitted to our hospital from January 2017 to
January 2019 were randomly divided into experimental group (n =31) and control group (n =29). The experimental group was
treated with Centella Triterpenes Cream on the basis of the control group, and the control group with fractional CO2 laser. The
keloid improvement, collagen fibers, and heat shock protein 47 before treatment and during the first and second courses of
treatment, the clinical efficacy and adverse reactions after treatment were compared. Results After treatment, the VSS scores of
the experimental group in the first and second courses were significantly lower than those in the control group (P ＜0.05).The
difference between the total collagen pixel area of the experimental group in the first and second courses was significantly lower
than that in the control group (P ＜0.05). The difference in shock protein 47 between the first course and the second course
of the experimental group was significantly lower than that of the control group, and the difference was statistically
significant (P ＜0.05). After treatment, the total effective rate of the experimental group was significantly higher than that of the
control group (74.19% vs. 48.27% , P ＜0.05). The adverse reaction rate of the experimental group was significantly lower than
that of the control group (35.48% vs. 65.51%, P ＞0.05). Conclusion Fractional CO2 laser combined with Centellaasiatica can
effectively improve keloid, collagen fibers and heat shock protein 47with good efficacy, which can reduce adverse reactions.

相似文献/References:

[1] 王东岺. 点阵CO2激光联合PDL激光治疗瘢痕疙瘩的疗效及不良反应分析[J].中国美容医学,2021,(9):89.
　 WANG Dong-ling. Efficacy and Adverse Reactions of Fractional CO2 Laser combined with PDL Laser inthe Treatment of Keloid[J].Medical Aesthetics and Beauty,2021,(6):89.
[2] 赵秀荣,陈 新,李 娜. 点阵CO2激光结合强脉冲光治疗中国人群的光老化皮肤临床效果及安全性研究[J].中国美容医学,2021,(9):103.
　 ZHAO Xiu-rong,CHEN Xin,LI Na. Study on the Clinical Effect and Safety of Carbon Dioxide Lattice Laser Combinedwith Intense Pulsed Light in the Treatment of Photoaged Skin in Chinese Population[J].Medical Aesthetics and Beauty,2021,(6):103.

更新日期/Last Update: 2021-07-13