基因多态性作为诊断及预防种植体周围炎的生物标记物研究进展-《中国美容医学》

文章信息/Info

作者:: 裴培1; 2 姬晓伟1; 2 韩祥祯1; 2 综述; 何惠宇1; 2 审校; (1.新疆医科大学第一附属医院附属口腔医院口腔修复科新疆乌鲁木齐 830054 ;2.新疆维吾尔自治区口腔医学研究所新疆乌鲁木齐 830011 )

Keywords:: peri-implantitis; single nucleotide polymorphism; interleukin; tumor necrosis factor-; matrix metalloproteinase

摘要:: 种植体目前已成为大多数缺失牙患者的第一选择，尽管其成功率超过90%，但每年因种植体周围炎导致种植失败的患者不在少数。种植体周围炎作为一种多因素的复杂性疾病，并不能单独用外源性因素来解释，目前已有大量研究报道单核苷酸多态性（Single nucleotide polymorphism,SNP）与种植体周围炎的关系，以期寻找新的分子诊断标记物。本文综述了目前国内外研究较多的炎症因子[白细胞介素（Interleukin,IL），肿瘤坏死因子-α（Tumor necrosis factor，TNF-α），金属基质蛋白酶（Matrix metalloproteinase,MMP）]等基因多态性与疾病易感性之间的结论，评估其作为生物标志物的可行性，并希望为种植体周围炎的诊断预防提供新思路。

Abstract:: Implant has become the first choice for most patients with missing tooth, although the success rate of implant is over 90 %, but there are few patients who is suffering implants failure because of peri-implant inflammation each year. Peri-implantitis is regarded as a multi-factor disease, it cannot be explained by exogenous factors alone, there are a number of studies reported the relationship between SNPs (Single nucleotide polymorphism, SNP) and peri-implantitis. In order to find new molecular diagnostic markers, we discussed the inflammatory factors which have been studied extensively at domestic and overseas (IL, TNF-α, MMP.etc) between gene polymorphism and susceptibility to Peri-implantitis, evaluated the feasibility of biomarkers and hope to provide a new idea for the diagnosis and prevention of peri-implantitis