[1]高存志,翁志洁,王 岩,等.清热除湿汤加减联合放血拔罐在急性湿疹皮损治疗中的临床应用[J].中国美容医学,2022,(6):110-114.
　GAO Cunzhi,WENG Zhijie,WANG Yan,et al.Clinical Application of Qingre Chushi Decoction Combined with Blood-letting Cupping in the Treatment of Acute Eczema[J].Medical Aesthetics and Beauty,2022,(6):110-114.
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清热除湿汤加减联合放血拔罐在急性湿疹皮损治疗中的临床应用()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2022年6期
页码:
110-114
栏目:
出版日期:
2022-06-10

文章信息/Info

Title:
Clinical Application of Qingre Chushi Decoction Combined with Blood-letting Cupping in the Treatment of Acute Eczema
文章编号:
1008-6455（2022）06-0110-05
作者:
高存志1 ; 翁志洁2 ; 王 岩3 ; 杨晓丽1
(秦皇岛市中医医院 1.皮肤科;2.门诊部;3.输血科 河北 秦皇岛 066000)
Author(s):
GAO Cunzhi1 ; WENG Zhijie2 ; WANG Yan3 ; YANG Xiaoli1
(1.Department of Dermatology; 2.Department of Outpatient; 3.Department of Blood Transfusion, Qinhuangdao Hospital of Traditional Chinese Medicine,Qinhuangdao 066000,Hebei,China)
关键词:
急性湿疹; 清热除湿汤; 放血拔罐; 免疫细胞; 炎性因子
Keywords:
acute eczema;  qingre chushi decoction;  bloodletting and cupping;  immune cells;  infl ammatory factors
分类号:
R758.23
文献标志码:
B
摘要:
目的：研究清热除湿汤加减联合放血拔罐对急性湿疹皮损疗效及血清T淋巴细胞亚群、Th2相关细胞因子水平的影响。 方法：选择秦皇岛市中医医院收治的96例急性湿疹患者作为研究对象，将其随机分为观察组（48例）和对照组（48例）。两 组采取常规西医治疗，观察组清热除湿汤联合放血拔罐治疗，对照组放血拔罐治疗。观察两组治疗3周后临床疗效、比较治 疗前后CD3＋、CD4＋、CD8＋、CD4＋/CD8＋、IL-4、IL-5、IL-13、IL-31水平。以ROC曲线及非条件Logistic逐步回归分析急性 湿疹短期疗效的影响因素。结果：治疗后，两组瘙痒、皮损面积、皮损形态评分均较治疗前降低，且观察组更低（P＜0.05）； 治疗后，观察组CD4＋水平高于对照组，CD8＋、IL-4、IL-31水平低于对照组（P＜0.05）；经ROC分析，CD4＋、CD8＋、IL-4、 IL-31预测急性湿疹皮损短期疗效曲线下面积为分别为0.776、0.790、0.819、0.691；经Logistic回归性分析显示CD4＋ ≥34.114%、CD8＋＜26.825%、IL-4＜12.525 pg/ml、IL-31＜22.040 pg/ml是治疗湿疹取得较好短期疗效的独立影响因素。 结论：清热除湿汤联合放血拔罐治疗湿疹能促进细胞免疫平衡恢复，减轻炎症反应，具有推广价值。
Abstract:
Objective To study the effect of Qingre Chushi decoction combined with blood-letting cupping on acute Eczema and the levels of T lymphocyte and TH2 related cytokines. Methods 96 patients with acute eczema in Qinhuangdao Hospital of traditional Chinese medicine were randomly divided into observation group (48 cases) and control group (48 cases). Two groups were treated with conventional Western medicine, observation group was treated with heat-clearing and dampnessremoving decoction combined with blood-letting cupping, and control group was treated with blood-letting cupping.The levels of differentiation cluster 3, CD3+ , CD4+ , CD8+ , CD4+ /CD8+ , IL-4, IL-5, IL-13 and IL-31 were compared before and after treatment. ROC curve and unconditional logistic regression were used to analyze the infl uencing factors of short-term effi cacy of acute eczema. Results After treatment, Pruritus, Lesion area and lesion morphological score in the two groups were lower than those before treatment, and the observation group was lower (P＜0.05). The level of CD4+ in the observation group was higher than that in the control group, and the levels of CD8+ , IL-4 and IL-31 in the observation group were lower than those in the control group (P＜0.05), ROC analysis showed that the area under the curve of CD4+ , CD8+ , IL-4 and IL-31 in predicting the short-term effi cacy of acute eczema lesions were 0.776, 0.790, 0.819 and 0.691, respectively (P＜0.05), Logistic regression analysis confi rmed that Qingre Chushi decoction combined with bloodletting and cupping can achieve good shortterm therapeutic eff ect. Meanwhile, CD4+ ≥34.114%, CD8+ ＜26.825%, IL-4＜12.525 pg/ml, IL-31＜22.040 pg/ml were the independent infl uencing factors of better short-term efficacy in the treatment of eczema. Conclusion Qingre Chushi decoction combined with bloodletting and cupping in the treatment of eczema can promote the recovery of cellular immune balance and reduce the infl ammatory reaction, which has promotion value.

相似文献/References:

[1]范 斌,刘荣奇,曹 洋.清热除湿汤加减联合IPL治疗轻中度脾胃湿热型玫瑰痤疮疗效研究[J].中国美容医学,2023,(3):116.
　FAN Bin,LIU Rongqi,CAO Yang.Curative Effect of Qingre Chushi Decoction Combined with IPL on Mild to Moderate Acne Rosacea of Spleen-stomach Damp-heat Type[J].Medical Aesthetics and Beauty,2023,(6):116.

备注/Memo

备注/Memo:
基金项目：秦皇岛市科学技术研究与发展计划（编号：202004A114）
更新日期/Last Update: 2022-07-05