[1]佘慧慧,李媛媛,王心培,等.多磺酸黏多糖乳膏联合异维A酸红霉素凝胶治疗轻中度玫瑰痤疮疗效观察[J].中国美容医学,2022,(11):66-70.
　SHE Huihui,LI Yuanyuan,WANG Xinpei,et al.Curative Effect of Polysulfonic Acid Mucopolysaccharide Cream Combined with Isotretinoin Erythromycin Gel on Mild to Moderate Rosacea[J].Medical Aesthetics and Beauty,2022,(11):66-70.
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多磺酸黏多糖乳膏联合异维A酸红霉素凝胶治疗轻中度玫瑰痤疮疗效观察()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2022年11期
页码:
66-70
栏目:
出版日期:
2022-11-10

文章信息/Info

Title:
Curative Effect of Polysulfonic Acid Mucopolysaccharide Cream Combined with Isotretinoin Erythromycin Gel on Mild to Moderate Rosacea
文章编号:
1008-6455（2022）11-0066-04
作者:
佘慧慧; 李媛媛; 王心培; 刘 婧
(南京医科大学第四附属医院皮肤科 江苏 南京 210031)
Author(s):
SHE Huihui;  LI Yuanyuan;  WANG Xinpei;  LIU Jing
(Department of Dermatology, the Fourth Affi liated Hospital of Nanjing Medical University, Nanjing 210031, Jiangsu, China)
关键词:
玫瑰痤疮; 多磺酸黏多糖乳膏; 异维A酸红霉素凝胶; 皮肤病生活质量指数量表; 玫瑰痤疮医师全球评分
Keywords:
rosacea;  polysulfonic acid mucopolysaccharide cream;  isotretinoin erythromycin gel;  dermatology life quality index;  physicians global assessment
分类号:
R758.73+ 4
文献标志码:
A
摘要:
目的：观察多磺酸黏多糖乳膏联合异维A酸红霉素凝胶治疗轻中度红斑毛细血管扩张型玫瑰痤疮的疗效。方法：选取 2019年1月-2021年12月在笔者医院确诊的60例轻中度红斑毛细血管扩张型玫瑰痤疮患者，采用简单随机分组将患者分为观察 组和对照组，每组30例。对照组患者采用异维A酸红霉素凝胶治疗，观察组采用多磺酸黏多糖乳膏联合异维A酸红霉素凝胶治 疗，均持续治疗6周。分别于治疗前后，记录皮损情况；采用使用玫瑰痤疮医师全球评分（PGA）对患者玫瑰痤疮情况进行 评分；使用皮肤病生活质量指数量表（DLQI）评估患者生活质量。记录两组治疗期间的不良反应发生情况。结果：观察组 治疗的有效率为86.67%，高于对照组的63.33%（P＜0.05）。治疗后，观察组患者皮损情况评分、PGA评分和DLQI评分均 明显低于对照组（P＜0.05）。观察组患者不良反应发生率为10.00%，低于对照组患者的23.33%，差异无统计学意义（P ＞0.05）。结论：多磺酸黏多糖乳膏联合异维A酸红霉素凝胶治疗可以明显提高玫瑰痤疮患者的临床疗效，改善皮损情况， 提高患者生活质量。
Abstract:
Objective To observe the curative effect of polysulfonic acid mucopolysaccharide cream combined with isotretinoin erythromycin gel on mild to moderate erythematotelangiectatic rosacea. Methods A total of 60 patients with mild to moderate erythematotelangiectatic rosacea confi rmed in the hospital were enrolled between January 2019 and December 2021. According to simple random grouping method, they were divided into observation group and control group, 30 cases in each group. The control group was treated with isotretinoin erythromycin gel, while observation group was additionally treated with polysulfonic acid mucopolysaccharide cream. All were continuously treated for 6 weeks. Before and after treatment, skin lesions were recorded. The rosacea conditions of patients were scored by physician’s global assessment (PGA). The quality of life was assessed by dermatology life quality index (DLQI). The occurrence of adverse reactions during treatment in both groups was recorded. Results The response rate of treatment in observation group was higher than that in control group (86.67% vs 63.33%, P＜0.05). After treatment, scores of skin lesions, PGA and DLQI in observation group were significantly lower than those in control group (P＜0.05), and incidence of adverse reactions was lower than that in control group (10.00% vs 23.33%, P＞ 0.05). Conclusion Polysulfonic acid mucopolysaccharide cream combined with isotretinoin erythromycin gel can signifi cantly improve clinical curative effect on rosacea patients, improve skin lesions and quality of life.

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更新日期/Last Update: 2022-11-17