[1]欧琳琳,周迎端,蒋明芝. 自体浓缩生长因子膜用于口腔黏膜组织缺损对疼痛度及瘢痕的影响[J].中国美容医学,2019,(09):107-109.
　OU Lin-lin,ZHOU Ying-duan,JIANG Ming-zhi. Effect of Autologous Concentrate Growth Factor Membrane on Pain And Scar inOral Mucosal Tissue Defect[J].Medical Aesthetics and Beauty,2019,(09):107-109.
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 自体浓缩生长因子膜用于口腔黏膜组织缺损对疼痛度及瘢痕的影响
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年09期
页码:
107-109
栏目:
出版日期:
2019-09-05

文章信息/Info

Title:
 Effect of Autologous Concentrate Growth Factor Membrane on Pain And Scar in
Oral Mucosal Tissue Defect
文章编号:
1008-6455（2019）09-0107-03
作者:
欧琳琳1; 周迎端2; 蒋明芝2
Author(s):
OU Lin-lin1; ZHOU Ying-duan2; JIANG Ming-zhi2
关键词:
[关键词]自体浓缩生长因子膜; 口腔黏膜组织缺损; 创面; 愈合; 瘢痕
Keywords:
Key words: autologous concentrated growth factor membrane;  oral mucosal tissue defect;  wound;  healing;  scar
分类号:
R781.5
文献标志码:
A
摘要:
[摘要]目的：观察自体浓缩生长因子膜用于口腔黏膜组织缺损对疼痛度及瘢痕的影响。方法：选取笔者医院口腔科2016年
1月-2018年12月收治的264例口腔黏膜组织缺损患者，按随机数表法分为观察组与对照组，每组132例。对照组：切除病变
后创面不贴敷任何物质，黏膜边缘直接缝线不剪断，用碘仿纱条反包扎固定牢固；观察组：切除病变后将CGF膜贴敷于创
面上，将CGF膜边缘与创缘无张力间断对角缝合，缝线保留不剪断，创面用碘仿纱条反包扎敷料固定牢固。比较两组术
后拆除碘仿纱条时间、创面愈合时间、术后2周、术后3周及术后4周的缺损面积愈合率及疼痛程度、术后3个月的术区
瘢痕。 结果：观察组拆除碘仿纱条时间与创面愈合时间分别为(7.25±1.65)d、(1.10±0.32)个月，显著短于对照组
(12.16±2.01)d、(1.79±0.45)个月(P ＜0.05)；观察组术后2周、3周、4周的缺损面积愈合率均显著高于对照组，差异有
统计学意义(P ＜0.05)；观察组术后2周、3周、4周的VAS评分显著低于对照组(P ＜0.05)；观察组术后3个月的VSS评分显著低
于对照组(P ＜0.05)。结论：CGF膜用于口腔黏膜组织缺损修复可加速创面愈合进展、减轻术后疼痛并抑制瘢痕形成，可尽快
恢复患者口腔正常功能，适合推广。

Abstract:
Abstract: Objective To observe the effect of autologous concentrate growth factor membrane on pain and scar in oral mucosal
tissue defect. Methods A total of 264 patients with oral mucosal tissue defects who were admitted to our department from
January 2016 to December 2018 were randomly divided into observation group and control group, with 132 cases in each group.
In the control group, the wound was not attached with any substance after the lesion was removed, and the suture at the edge of
the mucosa was not cut, and it was firmly fixed by iodoform gauze. After the lesion was removed from the observation group,
the CGF membrane was attached to the wound surface, and the edge of the CGF membrane was sutured obliquely without
tension at the wound edge. The suture remained uncut, and the wound surface was firmly fixed with the iodoform gauze antiwrap
dressing. The time of removal of iodoform gauze, the time of wound healing, the defect area healing rate and degree of
pain at 2 weeks, 3 weeks and 4 weeks after operation, the surgery scar at 3 months after operation were compared between two
groups. Results The time of removal of iodoform gauze, the time of wound healing in the observation group were (7.25±1.65)d
and (1.10±0.32)months, respectively, which were significantly shorter than (12.16±2.01)d and (1.79±0.45)months of the control
group (P ＜0.05). The wound healing rate of the observation group at 2 weeks, 3 weeks, and 4 weeks were significantly higher
than those of the control group, and the difference was statistically significant (P ＜0.05). The VAS scores of the observation
group at 2 weeks, 3 weeks, and 4 weeks after surgery were significantly lower than those of the control group (P ＜0.05). The
VSS score of the observation group at 3 months after operation was significantly lower than that of the control group (P ＜0.05).
Conclusion The CGF membrane for oral mucosal tissue defect repair can accelerate the healing of wound healing, reduce
postoperative pain and inhibit scar formation, and restore normal oral function of patients as soon as possible.
更新日期/Last Update: 2019-09-29