[1]唐黎珺,李笑眉,张筱薇,等.负压创面治疗技术联合重组人碱性成纤维细胞生长因子持续冲洗在慢性创面治疗中的应用[J].中国美容医学,2022,(8):36-39.
　TANG Lijun,LI Xiaomei,ZHANG Xiaowei,et al.Application of Negative Pressure Wound Therapy Combined with Recombinant Human Basic Fibroblast Growth Factor Continuous Flushing in the Treatment of Chronic Wound[J].Medical Aesthetics and Beauty,2022,(8):36-39.
点击复制

负压创面治疗技术联合重组人碱性成纤维细胞生长因子持续冲洗在慢性创面治疗中的应用()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2022年8期
页码:
36-39
栏目:
出版日期:
2022-08-10

文章信息/Info

Title:
Application of Negative Pressure Wound Therapy Combined with Recombinant Human Basic Fibroblast Growth Factor Continuous Flushing in the Treatment of Chronic Wound
文章编号:
1008-6455（2022）08-0036-03
作者:
唐黎珺1; 李笑眉2; 张筱薇2; 方强伟2; 金俊俊2; 鞠海宾2; 主父中印2; 徐 刚2; 罗 艺2
大连医科大学研究生院 辽宁 大连 116044 ;2.扬州大学附属苏北人民医院烧伤整形外科 江苏 扬州 225001
Author(s):
TANG Lijun1 ; LI Xiaomei2 ; ZHANG Xiaowei2 ; FANG Qiangwei2 ; JIN Junjun2 ; JU Haibin2 ;  ZHUFU Zhongyin2 ; XU Gang2 ; LUO Yi2
(1.Graduate School,Dalian Medical University,Dalian 116044,Liaoning,China;2.Department of Burn Plastic Surgery,Subei People’s Hospital Affi liated to Yangzhou University,Yangzhou 225001,Jiangsu,China)
关键词:
负压创面治疗技术; 重组人碱性成纤维细胞生长因子; 慢性创面; 创面修复; 疼痛; 感染
Keywords:
negative pressure wound therapy (NPWT);  recombinant human basic fibroblast growth factor (rh- bFGF);  chronic wound;  wound repair;  pain;  infected
分类号:
R622
文献标志码:
A
摘要:
目的：探讨负压创面治疗技术（Negative pressure wound therapy，NPWT）联合重组人碱性成纤维细胞生长因子 （Recombinant human basic fibroblast growth factor，rh-bFGF）持续冲洗治疗慢性创面的临床效果。方法：选取医院 烧伤整形外科2020年1月-12月收治的100例慢性创面患者为研究对象，随机分为A组和B组，每组各50例。A组采取NPWT联用生 理盐水冲洗治疗，B组为NPWT联用rh-bFGF溶液持续冲洗。比较两组肉芽组织覆盖率、疼痛评分、创面细菌阳性率及炎症指 标。结果：治疗后，两组疼痛评分、白细胞计数、C反应蛋白均降低，且B组低于A组，差异均有统计学意义（P＜0.05）。 B 组新生肉芽组织覆盖率和创面愈合率明显高于A组，创面细菌阳性率低于A组，差异均有统计学意义（P＜0.05）。结论： NPWT 联用rh-bFGF持续冲洗可降低创面感染率，促进一期肉芽组织新生，减少二期手术间隔时间，有一定临床应用价值。
Abstract:
Objective To observe the clinical effect of NPWT combined with rh-bFGF continuous fl ushing in the treatment of chronic wounds. Methods A total of 100 patients with chronic wounds treated in the department of burn and plastic surgery of our hospital from January to December 2020 were randomly divided into the group A (n=50) and the group B (n=50). The group A was treated with NPWT combined with normal saline, and the group B was treated with NPWT combined with rh- bFGF. The coverage rate of granulation tissue, pain score, bacteria positive rate and inflammation indexes of wound were compared between the two groups. Results After treatment, the pain score, WBC and C-reactive protein of the two groups decreased, and the group B were lower than the group A, the differences were statistically significant (P＜0.05). The coverage rate of new granulation tissue and wound healing rate in the group B were significantly higher than those in the group A (P＜0.05). The positive rate of wound bacteria in the group B was lower than that in the group A (P＜0.05). Conclusion NPWT combined with rh-bFGF can reduce wound infection rate, promote granulation regeneration of primary wound, and reduce the interval between secondary operations, which has certain clinical value.

相似文献/References:

[1]龚 丽,刘丽娟,侯 丽. rh-bFGF联合美容缝合技术在急诊开放性伤口处理中的应用[J].中国美容医学,2018,(06):22.
　GONG Li,LIU Li-juan,HOU Li. Application of rh-bFGF Combined with Cosmetic Suture Technique in Emergency Open Wound Management[J].Medical Aesthetics and Beauty,2018,(8):22.
[2]雷 磊,高 优,许建允,等. 游离植皮联合负压创面治疗技术治疗Ⅲ/Ⅳ度烧伤创面效果分析[J].中国美容医学,2018,(07):20.
　LEI Lei,GAO You,XU Jian-yun,et al. Application of Free Skin Grafting Combined with Negative Pressure Wound Therapy in the Treatment of Ⅲ/Ⅳ Degree Burns Wounds[J].Medical Aesthetics and Beauty,2018,(8):20.
[3] 吴 鹏,彭京梁,刘荣朋,等. 负压创面治疗技术联合皮瓣分期修复臀股部多发Ⅳ期压疮[J].中国美容医学,2020,(12):87.
　 WU Peng,PENG Jing-liang,LIU Rong-peng,et al. Application of Negative Pressure Wound Therapy Combined with Skin Flap in StagedRepair of Multiple Grade Ⅳ Pressure Ulcers in Buttock and Thigh[J].Medical Aesthetics and Beauty,2020,(8):87.
[4] 李 婷,潘建华,黄 峻,等. 序贯压力康复疗法联合负压创面治疗技术对手烧伤后瘢痕挛缩修复患者关节功能障碍及瘢痕情况的影响[J].中国美容医学,2021,(10):51.
　 LI Ting,PAN Jian-hua,HUANG Jun,et al. Effect of Sequential Pressure Rehabilitation Therapy Combined with NegativePressure Wound Therapy on Joint Dysfunction and Scar in Patients with ScarContracture after Hand Burn[J].Medical Aesthetics and Beauty,2021,(8):51.
[5]胡晓东,李永忠,蒋 朔.皮肤牵张闭合器联合负压创面治疗技术在慢性创面修复中的应用[J].中国美容医学,2022,(3):69.
　HU Xiaodong,LI Yongzhong,JIANG Shuo.The Application of Skin Stretch Occluder Combined with Negative Pressure Wound Treatment Technology in Chronic Wound Repair[J].Medical Aesthetics and Beauty,2022,(8):69.
[6]宋世珅,钱 青,高春岩,等.毫针联合外用重组人碱性成纤维细胞生长因子在面部年轻化治疗中的应用[J].中国美容医学,2022,(6):115.
　SONG Shishen,QIAN Qing,GAO Chunyan,et al.Millineedle Combined with Topical Recombinant Human Alkaline Fibroblast Growth Factor in Facial Rejuvenation[J].Medical Aesthetics and Beauty,2022,(8):115.
[7]周建文,陈志兵,李 丹,等.改良自制简易封闭式负压吸引装置在难愈性创面治疗中的应用[J].中国美容医学,2022,(8):42.
　ZHOU Jianwen,CHEN Zhibing,LI Dan,et al.Application of Improved Self-made Simple Closed Negative Pressure Suction Device in the Treatment of Refractory Wounds[J].Medical Aesthetics and Beauty,2022,(8):42.
[8]徐圣经,张 敏,徐文静,等.超脉冲点阵CO2激光联合rh-bFGF治疗凹陷性痤疮瘢痕的疗效及对ECCA评分的影响[J].中国美容医学,2022,(11):42.
　XU Shengjing,ZHANG Min,XU Wenjing,et al.Efficacy of Ultra-pulsed Fractional CO2 Laser Combined with Epidermal Growth Factor rh-bFGF in the Treatment of Depressed Acne Scars and Its Impact on ECCA Score[J].Medical Aesthetics and Beauty,2022,(8):42.
[9]林友淑,杨 洁,林飞燕.点阵Er:YAG激光联合rh-bFGF治疗面部萎缩性痤疮瘢痕的疗效及安全性分析[J].中国美容医学,2022,(11):55.
　LIN Youshu,YANG Jie,LIN Feiyan.Efficacy and Safety Analysis of Fractional Er:YAG Laser Combined with rh-bFGF in the Treatment of Facial Atrophic Acne Scars[J].Medical Aesthetics and Beauty,2022,(8):55.
[10]付永峰,王嘉欣,单 楠,等.负压创面治疗技术联合削痂植皮术在深度烧伤创面修复中的应用[J].中国美容医学,2024,(10):89.
　FU Yongfeng,WANG Jiaxin,SHAN Nan,et al.Application of Negative Pressure Wound Therapy Combined with Scab Removal and Skin Grafting in the Repair of Deep Burn Wounds[J].Medical Aesthetics and Beauty,2024,(8):89.

备注/Memo

备注/Memo:
基金项目：2020年度省中医药科技发展计划项目（编号：YB2020086）
更新日期/Last Update: 2022-08-22