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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:

期数:

2024年8期

页码:

119-122

栏目:

出版日期:

2024-08-10

文章信息/Info

Title:

Effi cacy of 308 nm Excimer Laser Combined with Compound Betamethasone in the Treatment of Patients with Advanced Vitiligo and Its Infl uence on Recurrence

文章编号:

1008-6455（2024）08-0119-04

作者:

孙圆圆; 赵世享; 陈 秋; 王 静; 夏 锋

[ 安徽医科大学附属宿州医院(宿州市立医院)

Author(s):

SUN Yuanyuan;  ZHAO Shixiang;  Chen Qiu;  WANG Jing;  XIA Feng

( Department of Dermatology, Suzhou Hospital Affi liated to Anhui Medical University, Suzhou 234000, Anhui, China )

关键词:

308 nm准分子光; 复方倍他米松; 白癜风; 皮损面积; 复发情况 [

Keywords:

308 nm excimer laser;  compound betamethasone;  vitiligo;  skin lesion area;  recurrence status

分类号:

R714.256

文献标志码:

A

摘要:

目的：探讨308 nm准分子光联合复方倍他米松治疗白癜风患者的临床效果及对病情复发的影响。方法：选取自2019年 6 月-2022年12月于安徽医科大学附属宿州医院-宿州市立医院皮肤科门诊就诊的白癜风患者105例，按照随机抛硬币法分为两 组，观察组53例，对照组52例。两组均采用308 nm准分子光治疗，观察组在此基础上选择复方倍他米松外敷，治疗3个月后 观察皮损面积、抗体水平、色素程度等。治疗结束跟踪观察12个月，检测白癜风复发情况。结果：治疗后，观察组的皮损面 积显著低于对照组（P＜0.05）；治疗后观察组的甲状腺过氧化物酶抗体（Thyroid peroxidase antibody，TPOAb），甲状 腺球蛋白抗体（Thyroglobulin antibody，TGAb），甲状腺受体抗体（Thyroid receptor antibody，TYR IgG）水平显著低 于对照组（P＜0.05）；治疗后观察组的3级以上色素恢复程度占比显著高于对照组（P＜0.05）；治疗3、6、12个月，观察 组患者白癜风活动程度（Vitiligo disease activity index，VIDA）评分显著低于对照组（P＜0.05）；两组不良反应发生 率比较差异无统计学意义（P＞0.05）。观察组治疗后12个月内白癜风复发率显著低于对照组（P＜0.05）。结论：308 nm准 分子光联合复方倍他米松比单独使用更能有效地治疗白癜风患者，显著改善皮损，提高自身免疫水平，提升整体色素恢复程 度，降低患者远期复发率，具有临床应用价值。

Abstract:

Objective To explore the clinical effect of 308 nm excimer laser combined with compound betamethasone in the treatment of patients with vitiligo and its infl uence on disease recurrence. Methods 105 patients with vitiligo who were treated in dermatology clinic of Suzhou Hospital of Anhui Medical University (Suzhou Municipal Hospital) from June 2019 to December 2022 were selected and divided into two groups according to random coin tossing method, including 53 cases in observation group and 52 cases in control group. Both groups were treated with 308 nm excimer laser, and the observation group was treated with compound betamethasone on this basis. The skin area, antibodies and pigment degree were observed after 3 months of treatment. End of treatment follow-up observation for 12 months, the recurrence of vitiligo was detected. Results After study and treatment, the skin area in observation group was signifi cantly smaller than that in control group (P ＜0.05). After treatment, the levels of thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) and thyroid receptor antibody (TYR IgG) were signifi cantly lower in observation group than those in control group (P ＜0.05). The proportion of pigment recovery degree above grade 3 in observation group after treatment was signifi cantly higher than that in control group (P ＜0.05). After 3, 6 and 12 months of treatment, the vitiligo disease activity index (VIDA) score in observation group was signifi cantly lower compared with that in control group (P ＜0.05). There was no signifi cant diff erence in the incidence of adverse reactions between the two groups (P ＞0.05). The recurrence rate of vitiligo in observation group within 12 months after treatment was signifi cantly lower than that in control group (P ＜0.05). Conclusion 308 nm excimer laser combined with compound betamethasone is more eff ective than single use in the treatment of patients with vitiligo, and the former one can more signifi cantly improve the skin lesions, increase the level of autoimmunity, enhance the overall pigment recovery degree, and reduce the long-term recurrence rate of patients, and it has clinical application value.

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更新日期/Last Update: 2024-08-17