[1]王 萃,张柳萦,黄卫新.肠道菌群与痤疮发生的相关性分析:110例肠道菌群样本的回顾性研究[J].中国美容医学,2018,(09):9-12.
 WANG Cui,ZHANG Liu-ying,HUANG Wei-xin.Correlation Analysis of Intestinal Microflora and Acne: A Retrospective Study on 110 Patients[J].Medical Aesthetics and Beauty,2018,(09):9-12.
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肠道菌群与痤疮发生的相关性分析:110例肠道菌群样本的回顾性研究
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2018年09期
页码:
9-12
栏目:
出版日期:
2018-10-10

文章信息/Info

Title:
Correlation Analysis of Intestinal Microflora and Acne: A Retrospective Study on 110 Patients
文章编号:
1008-6455(2018)09-0009-04
作者:
王 萃1张柳萦2黄卫新2
Author(s):
WANG Cui1ZHANG Liu-ying2HUANG Wei-xin2
关键词:
[关键词]痤疮肠道微生态聚合酶链式反应回顾性
Keywords:
Key words: acne intestinal microflora polymerase chain reaction(PCR) retrospective
分类号:
R758.73+3
文献标志码:
A
摘要:
[摘要]目的:探讨肠道菌群是否参与痤疮的发病。方法:回顾性调查分析树兰(杭州)医院曾进行肠道菌群检测的110例患
者。根据皮肤状态将其分为痤疮组和非痤疮组,并设计LND评分表对痤疮严重程度进行量化评估,运用R统计软件(t 检验,
皮尔逊相关性检验)进行两组间肠道6种优势细菌菌群差异分析。结果:两组肠道菌群多样性未发现显著差异,但痤疮组的
乳酸菌、双歧杆菌数量均少于非痤疮组,且痤疮组的双歧杆菌与肠杆菌比值(B/E值)低于非痤疮组,差异均有统计学意义
(P <0.05)。痤疮严重程度与B/E值之间并无统计意义的相关性。结论:痤疮患者肠道内益生菌数量的丢失可能参与痤疮的
发病机制,但痤疮严重程度与益生菌的丢失量之间并无线性相关。

Abstract:

Abstract: Objective In this study, we retrospective investigate changes in intestinal microflora in patients with acne, and their
role in this dermatological disorder. Methods 110 patients whose fecal flora were analyzed within a year were retrospective
studied. They were classified into acne group and non-acne group. LND tool was used to assess the acne. The numbers of
intestinal microflora between the two groups were statistical analyzed. Results The number of fecal lactobacillus, as well as
bifidobacterium were significantly deceased in patients with acne compared with the non-acne group, and B/E (Bifidobacterium/
Enterobacter) was significantly deceased in patients with acne compared with the non-acne group, the differences were
statistically significant(P <0.05). There was no statistically significant correlation between acne severity and B/E value.
Conclusion Intestinal flora in patients with acne was severely disturbed and gut microbiological colonization resistance was
impaired. Suggest that the alterations to the microbial flora, specially decreased probiotics, may involve in acne pathogenesis.

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更新日期/Last Update: 2018-10-31