[1]何 强 综述,张培华 审校. 间充质干细胞来源外泌体在创面修复中的作用及其机制研究进展[J].中国美容医学,2018,(09):143-148.
　HE Qiang,ZHANG Pei-hua. Progress of Exosomes Derived from Mesenchymal Stem Cells in Repair of Cutaneous Wound in Relation to Function and Mechanism[J].Medical Aesthetics and Beauty,2018,(09):143-148.
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 间充质干细胞来源外泌体在创面修复中的作用及其机制研究进展
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2018年09期
页码:
143-148
栏目:
出版日期:
2018-10-10

文章信息/Info

Title:
 Progress of Exosomes Derived from Mesenchymal Stem Cells in Repair of Cutaneous Wound in Relation to Function and Mechanism
文章编号:
1008-6455（2018）09-0143-06
作者:
 何 强 综述; 张培华 审校
Author(s):
 HE Qiang;  ZHANG Pei-hua
关键词:
 ; [关键词]外泌体; 间充质干细胞; 创面修复; 促进愈合; 抑制瘢痕
Keywords:
Key words: exosomes;  mesenchymal stem cells;  cutaneous wound repair;  improvement of healing;  inhibition of scar
分类号:
R641
文献标志码:
A
摘要:
[摘要]外泌体是细胞分泌的直径30～100nm的脂质双层膜囊泡。间充质干细胞的许多功能可通过其旁分泌的外泌体发挥作
用。研究表明，间充质干细胞来源外泌体能通过有效转运母细胞来源的特异性蛋白质、mRNA、microRNA、脂质等生物活性物
质进入靶细胞，调控创面愈合过程中炎症反应、细胞增殖、迁移、分化、血管生成与基质重建等多个阶段，促进创面愈合与
抑制瘢痕形成，提升创面修复能力，具有良好的临床应用前景。本文就间充质干细胞来源外泌体在创面修复中作用及机制进
行综述。

Abstract:

Abstract: Exosomes are lipid membrane-enclosed vesicles whose diameter is 30-100 nm secreted by various cell types, and
mesenchymal stem cells (MSCs) function via the paracrine pathway--exosomes. Recently, several studies have demonstrated
that exosomes derived from MSCs can effectively carry bioactive substance into recipient cells, such as specific proteins,
mRNAs, microRNAs and lipids derived from the parental cells. These mocular cargoes can regulate many biological processes
in the repair of cutaneous wound, such as the inflammatory response, cell proliferation, cell migration, cell differentiation,
blood vessel tube formation and matrix reconstruction, which not only promote wound healing but also inhibit the development
of scar to enhance the capacity for wound repair. Therefore, exosomes derived from MSCs have a good clinical application
prospect. This review will discuss the current literature regarding the role of exosomes derived from MSCs in cutaneous wound
repair, especially the function and mechanism.

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更新日期/Last Update: 2018-11-21