[1]王 迪,苗 青,王 萍. 白癜风患者血清中IL-33和TNF-α水平的研究[J].中国美容医学,2019,(02):91-93.
　WANG Di,MIAO Qing,WANG Ping. Serum Levels of IL-33 and TNF-α in Patients with Vitiligo[J].Medical Aesthetics and Beauty,2019,(02):91-93.
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 白癜风患者血清中IL-33和TNF-α水平的研究
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年02期
页码:
91-93
栏目:
出版日期:
2019-02-15

文章信息/Info

Title:
 Serum Levels of IL-33 and TNF-α in Patients with Vitiligo
文章编号:
1008-6455（2019）02-0091-03
作者:
王 迪; 苗 青; 王 萍
Author(s):
WANG Di; MIAO Qing; WANG Ping
关键词:
[关键词]白癜风; 白细胞介素-33; 肿瘤坏死因子-α; 免疫; 相关性
Keywords:
Key words: vitiligo;  interleukin-33;  tumor necrosis factor-α;  immunity;  correlation
分类号:
R758.4+1
文献标志码:
A
摘要:
[摘要]目的：检测白癜风患者血清白介素-33（IL-33）和肿瘤坏死因子-α（TNF-α）水平，探讨IL-33和TNF-α水平与白癜
风发生、发展之间的关系。方法：采用双抗体夹心酶联免疫吸附实验分别对41例白癜风患者及35例健康志愿者血清IL-33和
TNF-α的水平进行检测，比较不同分期白癜风患者与正常对照组血清中IL-33和TNF-α水平。结果：白癜风组血清IL-33、
TNF-α水平较健康对照组升高，差异具有统计学意义(P ＜0.05)；进展期、稳定期白癜风患者血清IL-33、TNF-α水平高于
健康对照组，且进展期高于稳定期，差异有统计学意义（P ＜0.05）；白癜风患者血清IL-33和TNF-α水平之间存在正相关
性（r =0.904，P ＜0.05）。结论：IL-33和TNF-α均作为促炎性因子参与了白癜风的发生、发展，血清水平可反映疾病进展
情况。

Abstract:

Abstract: Objective To evaluate the serum levels of IL-33 and TNF-α in patients with vitiligo,and to explore the relationship
between IL-33 and TNF-α levels and the development of vitiligo. Methods The concentrations of IL-33 and TNF-α in serum were
detected by enzyme linked immunosorbent assay (ELISA) in 41 patients with vitiligo and 35 healthy volunteers. The concentrations
of IL-33 and TNF-α in the serum of patients with different stages of vitiligo and normal control were compared. Results The levels
of IL-33 and TNF-α in the serum of patients with vitiligo were higher than those in the healthy control group. The difference was
statistically significant (P ＜0.05).The levels of serum IL-33 and TNF-α in the advanced and stable phases were higher than
those in the healthy control group, and the progression was higher than the stable phase. The difference was statistically significant.
(P ＜0.05).There was a positive correlation between the expression level of IL-33 and TNF-α(r =0.904,P ＜0.05). Conclusion
Vitiligo patients serum IL-33 and TNF-α are all proinflammatory factors involved in the pathogenesis of vitiligo, and serum
levels can reflect disease progression.

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更新日期/Last Update: 2019-03-07