[1]李 迪,刘 晶,夏 君,等. 新型超分子水杨酸联合米诺环素胶囊与克林霉素磷酸酯凝胶治疗寻常性痤疮疗效观察[J].中国美容医学,2019,(06):51-55.
 LI Di,LIU Jing,XIA Jun,et al. Efficacy of New Supramolecular Salicylic Acid Combined with Minocycline andClindamycin Phosphate Gel in the Treatment of Acne Vulgaris[J].Medical Aesthetics and Beauty,2019,(06):51-55.
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 新型超分子水杨酸联合米诺环素胶囊与克林霉素磷酸酯凝胶治疗寻常性痤疮疗效观察
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年06期
页码:
51-55
栏目:
出版日期:
2019-06-05

文章信息/Info

Title:
 Efficacy of New Supramolecular Salicylic Acid Combined with Minocycline and
Clindamycin Phosphate Gel in the Treatment of Acne Vulgaris
文章编号:
1008-6455(2019)06-0051-05
作者:
李 迪1刘 晶2夏 君2胡 蝶2胡光蕾2曾维惠2
Author(s):
LI Di1LIU Jing2XIA Jun2HU Die2HU Guang-lei2ZENG Wei-hui2
关键词:
[关键词]新型超分子水杨酸米诺环素寻常性痤疮克林霉素磷酸酯凝胶疗效联合治疗
Keywords:
Key words: new supramolecular salicylic acid minocycline acne vulgaris clindamycin phosphate gel efficacy combinationtherapy
分类号:
R758.73+3
文献标志码:
A
摘要:
[摘要]目的:观察新型超分子水杨酸联合米诺环素与克林霉素磷酸酯治疗寻常性痤疮的临床疗效。方法:选取80例寻常性痤
疮患者,随机分为新型超分子水杨酸联合米诺环素与克林霉素磷酸酯组(实验组),阿达帕林联合米诺环素与克林霉素磷酸
酯组(对照组),每组各40例,分别于治疗前及治疗后2、4、8、12周观察临床疗效。结果:治疗12周后,两组患者炎性皮
损数、非炎性皮损数及总皮损数较治疗前均明显减少。实验组与对照组的治疗总有效率虽无明显差异(P >0.05),但实验
组的基愈率明显高于对照组(P <0.05),不良反应(干燥、脱屑、红斑、瘙痒、灼热)发生率低于对照组。从第4周开始实
验组的总皮损减少速率明显快于对照组。结论:新型超分子水杨酸联合米诺环素、克林霉素磷酸酯治疗寻常性痤疮效果较
好,不良反应少。

Abstract:
Abstract: Objective To observe the efficacy of acne vulgaris treated with new supramolecular salicylic acid combined with
minocycline and clindamycin phosphate. Methods A total of 80 patients with acne vulgais were participated in this study. 40
cases were treated with new supramolecular salicylic acid combined with minocycline and clindamycin phosphate (research
group), while the other 40 cases were treated with adapalene gel combined with minocycline, clindamycin phosphate(control
group). The evaluations of the two groups were compared at baseline and after 2,4,8,12 weeks of treatment by a single-blind
investigator. Results After 12 weeks of treatment,both groups showd significant improvement, and both inflammatory as well
as non-inflammatory lesions were effectively reduced. There have not different in total effective rate between research group
and control group(P >0.05), however, the adverse reaction (dryness,peeling,erythem,burning and itching)of research group
was less than control group. In addition, total lesion counts in research group were decreased faster than control group after 4
weeks of treatment. Conclusion New supramolecular salicylic acid combined with minocycline and clindamycin phosphate is
effective in the treatment of acne vulgaris and is able to be better tolerated than adapalene gel.

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更新日期/Last Update: 2019-07-03