[1]熊 瑛,柴 宝,陈 婷,等.点阵激光联合2-甲氧基雌二醇对瘢痕疙瘩患者瘢痕VSS评分及TGF-β1的影响[J].中国美容医学,2019,(08):49-51.
　XIONG Ying,CHAI Bao,CHEN Ting,et al.Effect on VSS and TGF-β1 in Patients with Keloid Using Lattice Laser Combined with2-methoxyestradiol[J].Medical Aesthetics and Beauty,2019,(08):49-51.
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点阵激光联合2-甲氧基雌二醇对瘢痕疙瘩患者瘢痕VSS评分及TGF-β1的影响
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年08期
页码:
49-51
栏目:
出版日期:
2019-08-05

文章信息/Info

Title:
Effect on VSS and TGF-β1 in Patients with Keloid Using Lattice Laser Combined with
2-methoxyestradiol
文章编号:
1008-6455（2019）08-0049-03
作者:
熊 瑛1; 柴 宝2; 陈 婷1; 吴 波1
Author(s):
 XIONG Ying1; CHAI Bao2; CHEN Ting1; WU Bo1
关键词:
[关键词]点阵激光; 2-甲氧基雌二醇; 瘢痕疙瘩; 生长转化因子-β1; 温哥华瘢痕量表; 视觉模拟评分
Keywords:
Key words: lattice laser;  2-methoxyestradiol;  keloid;  growth transforming factor-β1;  vancouver scar scale;  visual analogue scale
分类号:
R619+.6
文献标志码:
A
摘要:
[摘要]目的：探究点阵激光联合2-甲氧基雌二醇对瘢痕疙瘩患者温哥华瘢痕量表（VSS）评分以及生长转化因子-β1
（TGF-β1）的影响。方法：选取笔者医院收治的瘢痕疙瘩患者112例，随机分为对照组和观察组，每组56例。两组患者均予
以点阵激光术治疗，观察组在此基础上加用2-甲氧基雌二醇擦拭施术部位。比较两组患者瘢痕测量指标、TGF-β1水平、不
良反应发生率、VSS评分、视觉模拟评分法（VAS）评分和完全上皮化时间。结果：对照组不良反应发生率为12.5%，观察组
不良反应发生率为5.36%，差异无统计学意义（P ＞0.05）。治疗后，观察组患者VAS评分和完全上皮化时间均低于对照组，
且差异具有统计学意义（P ＜0.05）。治疗后，两组患者瘢痕厚度、VSS评分和TGF-β1水平均降低，且观察组明显低于对照
组，差异具有统计学意义（P ＜0.05）。结论：在点阵激光基础上加用2-甲氧基雌二醇对瘢痕疙瘩治疗效果较好，可调节
TGF-β1的表达并促进瘢痕组织消退，并可效缓解患者疼痛，值得临床推广使用。

Abstract:
Abstract: Objective To investigate the effect on the score of vancouver scar scale (VSS) and growth transforming factor-
β1(TGF-β1) in patients with keloid using lattice laser combined with 2-methoxyestradiol. Methods 112 patients with keloid
admitted to our hospital were randomly divided into the control group and the observation group, with 56 cases in each group.
Both groups were treated with lattice laser, and the observation group was additionally wiped with 2-methoxyestradiol on
the basis of the control group. The levels of scar measurement index,TGF-β1, the incidence of adverse reactions, the score of
VSS, the score of visual analogue scale (VAS) and the time of complete epithelization were compared between the two groups.
Results There was no significant difference in the incidence of adverse reactions between the control group and the observation
group (12.5% vs 5.36%, P ＞0.05). After treatment, the score of VAS and time of complete epithelization in the observation
group were lower than those in the control group, with statistical difference (P ＜0.05). After treatment, the levels of scar
thickness and TGF-β1, the score of VSS in the two groups decreased, and the levels of scar thickness and TGF-β1, the score of
VSS in the observation group were significantly lower than those in the control group (P ＜0.05). Conclusion The addition of
2-methoxyestradiol to the treatment of keloid is effective on the basis of lattice laser. It can regulate the expression of TGF-β1 and
promote scar tissue regression, and can effectively relieve the pain of the patients, which is worth popularizing in clinic.

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[1]庄美平,陈建霞,缪 羽,等. 点阵激光美容修复静态眶周皱纹的临床研究[J].中国美容医学,2018,(10):69.
　ZHUANG Mei-ping,CHEN Jian-xia,MIAO Yu,et al. Clinical Study on Static Orbital Wrinkle Lattice Laser Cosmetology in the Repair of Static Orbital Wrinkles[J].Medical Aesthetics and Beauty,2018,(08):69.
[2]杨天赤,王 震,李卫华. CO2点阵激光预防面部整形术后早期切口瘢痕增生的疗效观察[J].中国美容医学,2019,(04):35.
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更新日期/Last Update: 2019-08-28