[1]李蕊联,周 俊,陆 美,等.低剂量异维A酸联合非剥脱点阵激光治疗寻常性痤疮疗效研究[J].中国美容医学,2019,(08):52-55.
 LI Rui-lian,ZHOU Jun,LU Mei,et al. The Efficacy of Low-dose Isotretinoin Combined with Nonablative Fractional Laser inthe Treatment of Acne Vulgaris[J].Medical Aesthetics and Beauty,2019,(08):52-55.
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低剂量异维A酸联合非剥脱点阵激光治疗寻常性痤疮疗效研究
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年08期
页码:
52-55
栏目:
出版日期:
2019-08-05

文章信息/Info

Title:
 The Efficacy of Low-dose Isotretinoin Combined with Nonablative Fractional Laser in
the Treatment of Acne Vulgaris
文章编号:
1008-6455(2019)08-0052-04
作者:
李蕊联周 俊陆 美李晓莉刘 艳王 梅曾维惠马慧群肖生祥
Author(s):
LI Rui-lianZHOU JunLU MeiLI Xiao-LiLIU YanWANG MeiZENG Wei-huiMA Hui-qunXIAO Sheng-xiang
关键词:
[关键词]非剥脱点阵激光异维A酸寻常性痤疮表面瘢痕深度瘢痕黑头粉刺
Keywords:
Key words: nonablative fractional laser isotretinoin acne vulgaris surface scar deep scar blackhead acne
分类号:
R758.73+3
文献标志码:
A
摘要:
[摘要]目的:探讨非剥脱点阵激光(Non-ablative fractional laser,NAFL)联合低剂量异维A酸治疗中重度寻常性痤疮的
临床疗效和安全性。方法:本研究纳入了2015年1月-2018年8月在笔者皮肤科门诊接受治疗的中重度寻常性痤疮患者317例。每天
口服10mg异维A酸,并接受单侧脸NAFL治疗5次。结果:低剂量异维A酸可以有效控制丘疹和结节病变(P<0.001)。与未治疗的
单侧脸相比较,NAFL治疗的单侧脸黑头粉刺(P<0.05)和萎缩性厢车型瘢痕(表面瘢痕,P<0.05;深度瘢痕,P <0.01)均明
显改善。口服异维A酸最常见的副作用是口干燥症和唇炎,与NAFL治疗相关的最常见副作用是治疗区域的轻度短暂性红斑和
水肿。结论:NAFL联合低剂量异维A酸治疗中重度寻常性痤疮安全、有效。

Abstract:
Abstract: Objective To investigate the clinical efficacy and safety of non-ablative fractional laser (NAFL) combined with lowdose
isotretinoin in the treatment of moderate to severe acne vulgaris. Methods This study included 317 patients with moderate
to severe acne vulgaris who were treated in our dermatology clinic from January 2015 to August 2018. The patient received
10mg of isotretinoin daily and received unilateral facial NAFL for 5 times. Results Low-dose isotretinoin was effective in
controlling papular and nodular lesions (P <0.001). Compared with untreated unilateral face, NAFL-treated unilateral face
blackhead acne (P <0.05) and atrophic car model scar (surface scar, P <0.05; deep scar, P <0.01) were significant improve. The
most common side effects of oral isotretinoin are xerostomia and cheilitis. The most common side effect associated with NAFL
treatment is mild transient erythema and edema in the treated area. Conclusion NAFL combined with low-dose isotretinoin is a
safe and effective treatment for moderate to severe acne.

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更新日期/Last Update: 2019-08-28