[1]李山林,陈小君,杨海微,等. 曲安奈德辅助激光治疗增生性瘢痕的疗效及对TGF-β1的影响[J].中国美容医学,2019,(12):66-69.
　LI Shan-lin,CHEN Xiao-jun,YANG Hai-wei,et al. Therapeutic Effect and the Effect of TGF-β1 of Patients with Hypertrophic Scar UsingTriamcinolone Acetonide-assisted Laser Therapy[J].Medical Aesthetics and Beauty,2019,(12):66-69.
点击复制

 曲安奈德辅助激光治疗增生性瘢痕的疗效及对TGF-β1的影响
()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年12期
页码:
66-69
栏目:
出版日期:
2019-12-05

文章信息/Info

Title:
 Therapeutic Effect and the Effect of TGF-β1 of Patients with Hypertrophic Scar Using
Triamcinolone Acetonide-assisted Laser Therapy

文章编号:
1008-6455（2019）12-0066-04
作者:
 李山林1; 陈小君2; 杨海微3; 付敬敏2
Author(s):
 LI Shan-lin1; CHEN Xiao-jun2; YANG Hai-wei3; FU Jing-min 2
关键词:
 ; [关键词]曲安奈德;  CO2点阵激光; 增生性瘢痕; 转化生长因子β1; 改良温哥华瘢痕量表
Keywords:
 ; Key words: triamcinolone acetonide;  CO2 lattice laser;  hypertrophic scar;  TGF-β1;  modified VSS
分类号:
R619+.6
文献标志码:
A
摘要:
[摘要]目的：探究曲安奈德辅助激光治疗增生性瘢痕（HS）的疗效及对转化生长因子β1（TGF-β1）的影响。方法：选取
2016年6月-2018年6月在笔者医院外科就诊的70例HS患者，随机分为曲安奈德组（35例）和激光组（35例）。所有患者均
给予醋酸曲安奈德局部注射治疗，激光组患者则在此基础上给予CO2点阵激光治疗。观测并比较两组患者的改良温哥华瘢
痕量表（VSS）评分、简明健康状况调查量表（SF-36）评分、瘢痕厚度以及TGF-β1相对含量。结果：治疗后，两组患者
的VSS评分、瘢痕厚度、TGF-β1相对含量均减少，且激光组的VSS评分、瘢痕厚度及TGF-β1相对含量均显著低于曲安奈
德组（P ＜0.05）。治疗后，两组患者的SF-36评分均增加，且激光组的SF-36评分显著高于曲安奈德组（P ＜0.05）。结
论：曲安奈德辅助CO2点阵激光治疗HS患者具有良好疗效，可有效降低VSS评分以及瘢痕厚度，改善患者生活质量，还可有效
降低瘢痕组织中TGF-β1相对含量，值得进一步研究与临床应用。

Abstract:
Abstract: Objective To investigate the therapeutic effect and level of ransforming growth factor-β1 (TGF-β1) in patients with
hypertrophic scar (HS) using triamcinolone acetonide-assisted laser therapy. Methods 70 patients with HS who were treated
in the surgery of our hospital from June 2016 to June 2018 were randomly divided into the triamcinolone acetonide group (35
cases) and the laser group (35 cases). All patients were given triamcinolone acetonide acetate local injection, and the laser group
was given CO2 lattice laser treatment on the basis of triamcinolone acetonide.The scores of modified Vancouver Scar Scale
(VSS) and Concise Health Survey Scale (SF-36), scar thickness and the expression of TGF-β1 were observed and compared
between the two groups. Results After treatment, the score of VSS, scar thickness and relative content of TGFβ1 decreased in
both groups, and the score of VSS , scar thickness and relative content of TGF-β1 in the laser group were significantly lower
than those in the triamcinolone acetonide group (P ＜0.05). After treatment, the score of SF-36 in both groups increased, and the
score of SF-36 in the laser group was significantly higher than that in the triamcinolone acetonide group (P ＜0.05). Conclusion
Triamcinolone acetonide-assisted CO2 lattice laser therapy has a good effect on patients with HS. It can effectively reduce the
score of VSS and scar thickness, improve the quality of life in patients, and effectively reduce the relative content of TGF-β1
expression in scar tissue. It is worth further study and clinical application.

相似文献/References:

[1]. 埋线美容专栏[J].中国美容医学,2018,(01):0.
　[J].Medical Aesthetics and Beauty,2018,(12):0.
[2]杨 震. 应用透明质酸颏部填充联合A型肉毒毒素咬肌注射重塑面部下1/3轮廓的效果观察[J].中国美容医学,2018,(03):1.
　YANG Zhen. Effect of Hyaluronic Acid Chin Filling Combined with Botulinum Toxin Type A Masseter Muscle Injection to Reconstruct the Facial Contour of the Lower 1/3[J].Medical Aesthetics and Beauty,2018,(12):1.
[3]祝闽辉,张栋梁,叶祥柏,等. 皮肤软组织扩张术埋置注液期并发症危险因素研究[J].中国美容医学,2018,(03):4.
　ZHU Min-hui,ZHANG Dong-liang,YE Xiang-bo,et al. Risk Factors of Complications after Tissue Expasion[J].Medical Aesthetics and Beauty,2018,(12):4.
[4]刘申松,杨永成. 自体脂肪颗粒移植联合假体隆乳术在哺乳后乳腺萎缩整形术中的应用[J].中国美容医学,2018,(03):9.
　LIU Shen-song,YANG Yong-cheng. Application of Autologous Fat Granule Graft Combined with Prosthesis Combined Augmentation Mammoplasty in Breast Reconstruction of Breast Atrophy Patients after Breast-feeding[J].Medical Aesthetics and Beauty,2018,(12):9.
[5]韩 星,胡守舵,陈晓芳,等.自体脂肪颗粒移植促进手部年轻化的临床观察[J].中国美容医学,2018,(03):12.
　HAN Xing,HU Shou-duo,CHEN Xiao-fang,et al. The Effect of Autologous Fat Grafting in Hand Rejuvenation[J].Medical Aesthetics and Beauty,2018,(12):12.
[6]李胜旭,苏映军,杨 宽,等. 封闭负压引流技术在先天性并指分指植皮术中的应用[J].中国美容医学,2018,(03):15.
　LI Sheng-xu,SU Ying-jun,YANG Kuan,et al. Application of Vacuum Sealing Drainage for Skin Graft in Patients with Congenital Syndactyly of the Hand[J].Medical Aesthetics and Beauty,2018,(12):15.
[7]陈 波,路 会,马 力,等. 钝针皮下层扇形注射透明质酸矫正面颊部凹陷[J].中国美容医学,2018,(03):18.
　CHEN Bo,LU Hui,MA Li,et al. Correction of Cheek Depression by Fanshaped Hyaluronic Acid Injection in Subcutaneous Layers with Blunt Needle[J].Medical Aesthetics and Beauty,2018,(12):18.
[8]曾德斌,栗鹏程,邱勋永,等. 不同超薄游离穿支皮瓣修复手部软组织缺损效果比较[J].中国美容医学,2018,(03):21.
　ZENG De-bin,LI Peng-cheng,QIU Xun-yong,et al. Comparison on the Repair Effect of Different Ultrathin Free Perforator Flaps in the Treatment of Patients with Soft Tissue Defect of Hand[J].Medical Aesthetics and Beauty,2018,(12):21.
[9]程 定,崔树英,郑 乐,等. 改道引流联合VSD技术修复会阴部撕裂伤的临床研究[J].中国美容医学,2018,(03):24.
　CHENG Ding,CUI Shu-ying,ZHENG Le,et al. Clinical Study on Diverted Drainage Combined with Vacuum Sealing Drainage Technique to Repair the Laceration of the Perineum[J].Medical Aesthetics and Beauty,2018,(12):24.
[10]李云峰,吴泽勇,黄海华,等. 全厚皮片游离移植矫治儿童足背瘢痕挛缩畸形[J].中国美容医学,2018,(03):27.
　LI Yun-feng,WU Ze-yong,HUANG Hai-hua,et al. Full-thickness Skin Graft for the Treatment of Cicatricial Contracture of the Dorsum of Foot in Children[J].Medical Aesthetics and Beauty,2018,(12):27.
[11]俞 舜. 微等离子体射频联合曲安奈德超声导入治疗增生性瘢痕疗效分析[J].中国美容医学,2019,(02):63.
　YU Shun. Clinical Study on Microplasma Radiofrequency Combined with Ultrasonic ImportingTriamcinolone Acetonide in the Treatment of Hypertrophic Scar[J].Medical Aesthetics and Beauty,2019,(12):63.

更新日期/Last Update: 2020-01-06