[1]陈长洋,林志群,李小瑜. 阿维A对银屑病患者的治疗效果及相关细胞因子水平变化研究[J].中国美容医学,2019,(12):88-90.
 CHEN Chang-yang,LIN Zhi-qun,LI Xiao-yu. Study on the Effect of Acitretin on Psoriasis Patients and the Change of Cytokines[J].Medical Aesthetics and Beauty,2019,(12):88-90.
点击复制

 阿维A对银屑病患者的治疗效果及相关细胞因子水平变化研究
()
分享到:

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年12期
页码:
88-90
栏目:
出版日期:
2019-12-05

文章信息/Info

Title:
 Study on the Effect of Acitretin on Psoriasis Patients and the Change of Cytokines
文章编号:
1008-6455(2019)12-0088-03
作者:
 陈长洋林志群李小瑜
Author(s):
 CHEN Chang-yangLIN Zhi-qunLI Xiao-yu
关键词:
 [关键词]阿维A胶囊银屑病超氧化物歧化酶过氧化脂质过氧化氢酶皮损面积血管内皮细胞生长因子
Keywords:
 Key words: acitretin psoriasis superoxide dismutase lipid peroxides catalase leather area vascular endothelial growth factor
分类号:
R758.63
文献标志码:
A
摘要:
[摘要]目的:探讨阿维A对银屑病患者的治疗效果及对细胞因子水平的影响。方法:选取笔者医院2016年4月-2018年10月
收治的银屑病患者114例,根据治疗方法不同分为两组。对照组给予免疫调节、皮质类固醇激素等药物并配合抗炎保肝等
对症治疗,观察组在对照组基础上给予阿维A治疗,分析两组患者治疗后的临床疗效。结果:观察组总有效率为84.21%,
对照组为66.67%,差异有统计学意义(P <0.05)。两组治疗前银屑病面积严重程度指数(Psoriasis area and severity
index,PASI)评分组间比较,差异不具有统计学意义(P >0.05);治疗后观察组PASI评分低于对照组,差异有统计学意
义(P <0.05)。两组治疗前超氧化物歧化酶(Superoxide Dismutase,SOD)、过氧化脂质(Lipoperoxides,LPO)、
过氧化氢酶(Catalase,CAT)、缺氧诱导因子-1α(Hypoxic Induction Factor-1α,HIF-1α)、白细胞介素-17
(Interleukin-17,IL-17)、血管内皮细胞生长因子(Vascular endothelial growth factor,VEGF)水平组间比较,差
异不具有统计学意义(P >0.05)。治疗后观察组SOD、CAT水平高于对照组,LPO、HIF-1α、IL-17、VEGF水平低于对照组,
差异有统计学意义(P <0.05)。结论:阿维A治疗银屑病可缩小皮损面积,降低HIF-1α、IL-17、VEGF的表达水平,改善氧
化应激状态。

Abstract:
Abstract: Objective To analyze the effect of acitretin on psoriasis and its effect on cytokine level. Methods 114 patients with
psoriasis treated in our hospital from April 2016 to October 2018 were divided into two groups according to different treatment
methods. The patients in the control group were treated with immunomodulation, corticosteroids and other drugs combined
with anti-inflammatory and liver-protecting therapy, and the observation group was treated with acitretin on the basis of the
control group. The clinical curative effects of the two groups after treatment were analyzed. Results The total effective rate
of the observation group was 84.21%, and the control group was 66.67%, the difference was statistically significant(P <0.05).
There was no significant difference between the two groups in PASI score before treatment(P >0.05). After treatment, PASI
score in the observation group was lower than that in the control group, and the difference was statistically significant(P <0.05).
There was no significant difference in the levels of Superoxide dismutase(SOD), Lipoperoxides(LPO), Catalase(CAT),Hypoxic
induction factor-1α(HIF-1α), Interleukin-17(IL-17), Vascular endothelial growth factor(VEGF) between the two groups before
treatment(P>0.05). After treatment, the levels of SOD and CAT in the observation group were higher than those in the control group,
while the levels of LPO, HIF-1 α, IL-17 and VEGF in the observation group were lower than those in the control group(P<0.05). Conclusion
Treatment of psoriasis with acitretin can reduce the area of skin lesion, decrease the expression of HIF-1 α and IL-17,VEGF, and improve
the state of oxidative stress.

相似文献/References:

[1]. 埋线美容专栏[J].中国美容医学,2018,(01):0.
 [J].Medical Aesthetics and Beauty,2018,(12):0.
[2]杨 震. 应用透明质酸颏部填充联合A型肉毒毒素咬肌注射重塑面部下1/3轮廓的效果观察[J].中国美容医学,2018,(03):1.
 YANG Zhen. Effect of Hyaluronic Acid Chin Filling Combined with Botulinum Toxin Type A Masseter Muscle Injection to Reconstruct the Facial Contour of the Lower 1/3[J].Medical Aesthetics and Beauty,2018,(12):1.
[3]祝闽辉,张栋梁,叶祥柏,等. 皮肤软组织扩张术埋置注液期并发症危险因素研究[J].中国美容医学,2018,(03):4.
 ZHU Min-hui,ZHANG Dong-liang,YE Xiang-bo,et al. Risk Factors of Complications after Tissue Expasion[J].Medical Aesthetics and Beauty,2018,(12):4.
[4]刘申松,杨永成. 自体脂肪颗粒移植联合假体隆乳术在哺乳后乳腺萎缩整形术中的应用[J].中国美容医学,2018,(03):9.
 LIU Shen-song,YANG Yong-cheng. Application of Autologous Fat Granule Graft Combined with Prosthesis Combined Augmentation Mammoplasty in Breast Reconstruction of Breast Atrophy Patients after Breast-feeding[J].Medical Aesthetics and Beauty,2018,(12):9.
[5]韩 星,胡守舵,陈晓芳,等.自体脂肪颗粒移植促进手部年轻化的临床观察[J].中国美容医学,2018,(03):12.
 HAN Xing,HU Shou-duo,CHEN Xiao-fang,et al. The Effect of Autologous Fat Grafting in Hand Rejuvenation[J].Medical Aesthetics and Beauty,2018,(12):12.
[6]李胜旭,苏映军,杨 宽,等. 封闭负压引流技术在先天性并指分指植皮术中的应用[J].中国美容医学,2018,(03):15.
 LI Sheng-xu,SU Ying-jun,YANG Kuan,et al. Application of Vacuum Sealing Drainage for Skin Graft in Patients with Congenital Syndactyly of the Hand[J].Medical Aesthetics and Beauty,2018,(12):15.
[7]陈 波,路 会,马 力,等. 钝针皮下层扇形注射透明质酸矫正面颊部凹陷[J].中国美容医学,2018,(03):18.
 CHEN Bo,LU Hui,MA Li,et al. Correction of Cheek Depression by Fanshaped Hyaluronic Acid Injection in Subcutaneous Layers with Blunt Needle[J].Medical Aesthetics and Beauty,2018,(12):18.
[8]曾德斌,栗鹏程,邱勋永,等. 不同超薄游离穿支皮瓣修复手部软组织缺损效果比较[J].中国美容医学,2018,(03):21.
 ZENG De-bin,LI Peng-cheng,QIU Xun-yong,et al. Comparison on the Repair Effect of Different Ultrathin Free Perforator Flaps in the Treatment of Patients with Soft Tissue Defect of Hand[J].Medical Aesthetics and Beauty,2018,(12):21.
[9]程 定,崔树英,郑 乐,等. 改道引流联合VSD技术修复会阴部撕裂伤的临床研究[J].中国美容医学,2018,(03):24.
 CHENG Ding,CUI Shu-ying,ZHENG Le,et al. Clinical Study on Diverted Drainage Combined with Vacuum Sealing Drainage Technique to Repair the Laceration of the Perineum[J].Medical Aesthetics and Beauty,2018,(12):24.
[10]李云峰,吴泽勇,黄海华,等. 全厚皮片游离移植矫治儿童足背瘢痕挛缩畸形[J].中国美容医学,2018,(03):27.
 LI Yun-feng,WU Ze-yong,HUANG Hai-hua,et al. Full-thickness Skin Graft for the Treatment of Cicatricial Contracture of the Dorsum of Foot in Children[J].Medical Aesthetics and Beauty,2018,(12):27.

更新日期/Last Update: 2020-01-07