[1]张春玲,陈 露,赵 伟,等. 丹银海绵对糖尿病大鼠皮肤溃疡创面愈合的影响[J].中国美容医学,2020,(3):71-74.
　ZHANG Chun-ling,CHEN Lu,ZHAO Wei,et al. Effect of Danyin Sponge on Skin Ulcer Wound Healing in Diabetic Rats[J].Medical Aesthetics and Beauty,2020,(3):71-74.
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 丹银海绵对糖尿病大鼠皮肤溃疡创面愈合的影响
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年3期
页码:
71-74
栏目:
出版日期:
2020-04-15

文章信息/Info

Title:
 Effect of Danyin Sponge on Skin Ulcer Wound Healing in Diabetic Rats
文章编号:
1008-6455（2020）03-0071-04
作者:
 张春玲1; 陈 露2; 赵 伟2; 黄 蔷3; 龙 丽4; 李 桃5; 唐丽莎5; 罗开中5
Author(s):
 ZHANG Chun-ling1; CHEN Lu2; ZHAO Wei2; HUANG Qiang3; LONG Li4; LI Tao5; TANG Li-sha5; LUO Kai-zhong5
关键词:
 ; [关键词]丹银海绵; 糖尿病; 皮肤溃疡; AGEs; 生长因子; 炎症因子; 创面愈合
Keywords:
 ; Key words: Dan silver sponge;  diabetes;  skin ulcers;  AGEs;  growth factors;  infl ammatory factors;  wound healing
分类号:
R285
文献标志码:
A
摘要:
[摘要]目的：探讨丹银海绵对糖尿病大鼠皮肤溃疡创面愈合的影响。方法：将雄性Wistar大鼠随机分为8组。除空白对照组
外，其余7组大鼠，通过手术在其背部形成一10mm×10mm相同大小，深达肌层的溃疡，分别给予抗生素、生长因子凝胶、纳
米银、丹黄散，以及不同浓度的丹银海绵处理溃疡面。给药28d后处死大鼠，取溃疡部位新生肉芽组织，HE染色观察组织形
态的变化；Western Blot检测大鼠创面组织中AGEs、hs-CRP、IL-1、IL-6、bFGF、PDGF、VEGF表达水平。结果：病理切片观
察显示适宜浓度的丹银海绵可以促进血管新生并伴扩张，同时生成大量新生成纤维细胞。Western Blot检测显示高浓度的丹
银海绵可以显著上调创面组织中生长因子表达（P ＜0.05），降低AGEs水平及炎症因子表达（P ＜0.05）。结论：适宜浓度的
丹银海绵对于糖尿病大鼠皮肤溃疡的愈合有明显的促进作用，提高治疗效果。

Abstract:
Abstract: Objective To investigate the effect of Dan silver sponge on wound healing of diabetic rats with skin ulcers.
Methods Male Wistar rats were randomly divided into 8 groups. Except for the control group, in the other 7 groups of rats, a
10mm×10mm ulcer was created on the back by surgery, and the depth of the ulcer reached the muscle layer. Treatment of ulcers
with antibiotics, growth factor gel, nanosilver, Danhuang powder, and different concentrations of Dan silver sponge.The rats
were sacrifi ced 28d after administration, and the new granulation tissue of the ulcer was taken. The histomorphological changes
were observed by HE staining. The expression levels of AGEs, hs-CRP, IL-1, IL-6, bFGF, PDGF and VEGF in rat wound
tissues were detected by Western Blot. Results Pathological sections showed that the appropriate concentration of Dan silver
sponge can promote angiogenesis and expansion, and generate a large number of new fi broblasts. Western Blot assay indicated
that high concentration of Dan silver sponge signifi cantly up-regulated the expression of growth factor in wound tissue (P ＜0.05),
and decreased the expression of AGEs and infl ammatory factors (P ＜0.05). Conclusion The appropriate concentration of Dan
silver sponge can promote the healing of skin ulcer in diabetic rats and improve the effi cacy.

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更新日期/Last Update: 2020-04-28