[1]高栋梁,张 雷. 水胶体敷料在大面积烧伤患者中的应用效果及促进创面愈合机制探讨[J].中国美容医学,2020,(4):90-93.
　GAO Dong-liang,ZHANG Lei. The Application Effect of Hydrocolloid Dressing in Large Area Burn Patients and theMechanism of Promoting Wound Healing[J].Medical Aesthetics and Beauty,2020,(4):90-93.
点击复制

 水胶体敷料在大面积烧伤患者中的应用效果及促进创面愈合机制探讨
()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年4期
页码:
90-93
栏目:
出版日期:
2020-04-28

文章信息/Info

Title:
 The Application Effect of Hydrocolloid Dressing in Large Area Burn Patients and the
Mechanism of Promoting Wound Healing
文章编号:
1008-6455（2020）04-0090-04
作者:
 高栋梁; 张 雷
Author(s):
 GAO Dong-liang; ZHANG Lei
关键词:
 ; [关键词]大面积烧伤; 水胶体敷料; 创面愈合机制; 炎性细胞因子; 血管内皮生长因子; 碱性成纤维细胞生长因子
Keywords:
 ; Key words: large area burns;  hydrocolloid dressings;  wound healing mechanism;  infl ammatory cytokines;  vascular endothelialgrowth factor;  basic fi broblast growth factor
分类号:
R644
文献标志码:
A
摘要:
[摘要]目的：分析水胶体敷料在大面积烧伤患者中的应用效果及其促进创面愈合机制。方法：选择笔者医院2018年1
月-2019年6月收治的200例大面积烧伤患者，以随机数表法分为采取纱布加压包扎的对照组以及采取水胶体敷料包扎的
观察组，各100例，两组均接受Meek植皮术治疗，对两组创面愈合时间、创面细菌定量、炎性细胞因子（C反应蛋白、
白介素6、转化生长因子-β1）、血管新生指标（血管内皮生长因子、碱性成纤维细胞生长因子）进行比较。结果：
观察组创面愈合时间（19.85±1.15）d，短于对照组（25.50±1.50）d，创面细菌定量（420.25±15.20）cfu/g
小于对照组（877.50±15.35）cfu/g，差异有统计学意义（t =29.893、211.667，P 均=0.000）。治疗后观察组C反应
蛋白（9.25±1.05）mg/L、白介素6（71.10±12.10）ng/L、转化生长因子-β1（9.33±1.17）μg/L，低于对照组
（12.11±1.08）mg/L、（84.88±12.82）ng/L、（12.14±1.12）μg/L，差异有统计学意义（t =18.987、77.245、
17.349，P 均=0.000）。观察组血管内皮生长因子（140.29±1.61）ng/L、碱性成纤维细胞生长因子（88.92±1.18）ng/L，
高于对照组（124.38±1.52）ng/L、（79.86±1.24）ng/L，差异有统计学意义（t =71.856、52.929，P 均=0.000）。结论：
在大面积烧伤患者治疗中水胶体敷料能够通过抑制炎症反应、促进血管新生来促进创面愈合，值得在今后临床治疗工作中推
广使用。

Abstract:
Abstract: Objective To analyze the application effect of hydrocolloid dressing in large area burn patients and its mechanism
of promoting wound healing. Methods A total of 200 patients with extensive burns admitted to our hospital from January
2018 to June 2019 were enrolled. The randomized number grouping method was divided into the control group with gauze
pressure bandage and the observation group with hydrocolloid dressing. Both groups were treated with Meek skin grafting,
wound healing time, bacterial count of wounds, inflammatory cytokines (C-reactive protein, interleukin 6, transforming
growth factor-β1), angiogenesis index (vascular endothelial growth factor, basic fi broblast growth factor) was compared.
Results The wound healing time of the observation group was (19.85±1.15)d, which was shorter than that of the control
group (25.50±1.50)d, and the bacterial count of the wound was (420.25±15.20)cfu/g, which was smaller than that of
the control group (877.50±15.35)cfu/g, the differences were statistically signifi cant (t =29.893, 211.667, P =0.000). After
treatment, C-reactive protein (9.25±1.05)mg/L, interleukin-6 (71.10±12.10)ng/L, transforming growth factor-β1 (9.33±1.17)
μg/L, lower than the control group (12.11±1.08)mg/L, (84.88±12.82)ng/L, (12.14±1.12)μg/L, the differences were statistically
signifi cant (t =18.987, 77.245, 17.349, P =0.000). The vascular endothelial growth factor (140.29±1.61)ng/L and basic fi broblast
growth factor (88.92±1.18)ng/L were higher than the control group (124.38±1.52)ng/L, (79.86±1.24)ng/L, the differences
were statistically signifi cant (t =71.856, 52.929, P = 0.000). Conclusion Hydrocolloid dressing can promote wound healing
by inhibiting infl ammatory reaction and promoting angiogenesis in the treatment of large-area burn patients. It is worthy of
popularization in clinical treatment work in the future.

相似文献/References:

[1]. 埋线美容专栏[J].中国美容医学,2018,(01):0.
　[J].Medical Aesthetics and Beauty,2018,(4):0.
[2]杨 震. 应用透明质酸颏部填充联合A型肉毒毒素咬肌注射重塑面部下1/3轮廓的效果观察[J].中国美容医学,2018,(03):1.
　YANG Zhen. Effect of Hyaluronic Acid Chin Filling Combined with Botulinum Toxin Type A Masseter Muscle Injection to Reconstruct the Facial Contour of the Lower 1/3[J].Medical Aesthetics and Beauty,2018,(4):1.
[3]祝闽辉,张栋梁,叶祥柏,等. 皮肤软组织扩张术埋置注液期并发症危险因素研究[J].中国美容医学,2018,(03):4.
　ZHU Min-hui,ZHANG Dong-liang,YE Xiang-bo,et al. Risk Factors of Complications after Tissue Expasion[J].Medical Aesthetics and Beauty,2018,(4):4.
[4]刘申松,杨永成. 自体脂肪颗粒移植联合假体隆乳术在哺乳后乳腺萎缩整形术中的应用[J].中国美容医学,2018,(03):9.
　LIU Shen-song,YANG Yong-cheng. Application of Autologous Fat Granule Graft Combined with Prosthesis Combined Augmentation Mammoplasty in Breast Reconstruction of Breast Atrophy Patients after Breast-feeding[J].Medical Aesthetics and Beauty,2018,(4):9.
[5]韩 星,胡守舵,陈晓芳,等.自体脂肪颗粒移植促进手部年轻化的临床观察[J].中国美容医学,2018,(03):12.
　HAN Xing,HU Shou-duo,CHEN Xiao-fang,et al. The Effect of Autologous Fat Grafting in Hand Rejuvenation[J].Medical Aesthetics and Beauty,2018,(4):12.
[6]李胜旭,苏映军,杨 宽,等. 封闭负压引流技术在先天性并指分指植皮术中的应用[J].中国美容医学,2018,(03):15.
　LI Sheng-xu,SU Ying-jun,YANG Kuan,et al. Application of Vacuum Sealing Drainage for Skin Graft in Patients with Congenital Syndactyly of the Hand[J].Medical Aesthetics and Beauty,2018,(4):15.
[7]陈 波,路 会,马 力,等. 钝针皮下层扇形注射透明质酸矫正面颊部凹陷[J].中国美容医学,2018,(03):18.
　CHEN Bo,LU Hui,MA Li,et al. Correction of Cheek Depression by Fanshaped Hyaluronic Acid Injection in Subcutaneous Layers with Blunt Needle[J].Medical Aesthetics and Beauty,2018,(4):18.
[8]曾德斌,栗鹏程,邱勋永,等. 不同超薄游离穿支皮瓣修复手部软组织缺损效果比较[J].中国美容医学,2018,(03):21.
　ZENG De-bin,LI Peng-cheng,QIU Xun-yong,et al. Comparison on the Repair Effect of Different Ultrathin Free Perforator Flaps in the Treatment of Patients with Soft Tissue Defect of Hand[J].Medical Aesthetics and Beauty,2018,(4):21.
[9]程 定,崔树英,郑 乐,等. 改道引流联合VSD技术修复会阴部撕裂伤的临床研究[J].中国美容医学,2018,(03):24.
　CHENG Ding,CUI Shu-ying,ZHENG Le,et al. Clinical Study on Diverted Drainage Combined with Vacuum Sealing Drainage Technique to Repair the Laceration of the Perineum[J].Medical Aesthetics and Beauty,2018,(4):24.
[10]李云峰,吴泽勇,黄海华,等. 全厚皮片游离移植矫治儿童足背瘢痕挛缩畸形[J].中国美容医学,2018,(03):27.
　LI Yun-feng,WU Ze-yong,HUANG Hai-hua,et al. Full-thickness Skin Graft for the Treatment of Cicatricial Contracture of the Dorsum of Foot in Children[J].Medical Aesthetics and Beauty,2018,(4):27.
[11]熊 琴,唐 亚,朱雅竹. 大面积烧伤患者发生早期深静脉置管导管相关性血流感染的危险因素分析[J].中国美容医学,2019,(11):26.
　XIONG Qin,TANG Ya,ZHU Ya-zhu. Risk Factors Analysis of Early Deep Venous Catheter-related Blood Stream Infectionin Patients with Extensive Burns[J].Medical Aesthetics and Beauty,2019,(4):26.

更新日期/Last Update: 2020-04-28