[1]方兆珺,李俊杰,周韵聪,等. NB-UVB联合复方白芷酊及卤米松乳膏对进展期白癜风患者AMMC细胞黑素合成量的影响[J].中国美容医学,2020,(4):105-108.
　FANG Zhao-jun,LI Jun-jie,ZHOU Yun-cong,et al. Effects of NB-UVB Combined with Compound Angelica Dahurica Tincture andHalometasone Cream on Melanin Synthesis in AMMC Cells of Patients withProgressive Vitiligo[J].Medical Aesthetics and Beauty,2020,(4):105-108.
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 NB-UVB联合复方白芷酊及卤米松乳膏对进展期白癜风患者AMMC细胞黑
素合成量的影响
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年4期
页码:
105-108
栏目:
出版日期:
2020-04-28

文章信息/Info

Title:
 Effects of NB-UVB Combined with Compound Angelica Dahurica Tincture and
Halometasone Cream on Melanin Synthesis in AMMC Cells of Patients with
Progressive Vitiligo
文章编号:
1008-6455（2020）04-0105-03
作者:
 方兆珺; 李俊杰; 周韵聪; 唐亚平
Author(s):
 FANG Zhao-jun; LI Jun-jie; ZHOU Yun-cong; TANG Ya-ping
关键词:
 ; [关键词]进展期白癜风; 窄谱中波紫外线; 复方白芷酊; 卤米松乳膏; 毛囊外根鞘; 无色素黑素细胞; 黑素合成
Keywords:
 ; Key words: progressive vitiligo;  narrow-band ultraviolet B (NB-UVB);  compound angelica dahurica tincture;  halometasonecream;  outer root sheath of hair follicle;  amelanotic melanocyte(AMMC);  melanin synthesis
分类号:
R758.4+1
文献标志码:
A
摘要:
[摘要]目的：探究窄谱中波紫外线（NB-UVB）联合复方白芷酊及卤米松乳膏对进展期白癜风疗效及患者毛囊外根鞘无色素黑
素细胞（AMMC）黑素合成情况的影响。方法：选取2016年12月-2019年3月在笔者医院皮肤科就诊的70例进展期白癜风患者，
随机分成常规组（35例）和联合组（35例）。常规组给予卤米松乳膏+NB-UVB治疗，联合组在常规组的基础上加用复方白芷
酊。两组患者均连续治疗24周。观察并比较两组疗效、不良反应发生情况及AMMC细胞黑素合成量。结果：治疗12周时，联
合组与常规组总有效率比较差异无统计学意义（82.86% vs 68.57%，P ＞0.05）；治疗24周时，联合组总有效率高于常规组
（97.14% vs 80.00%），差异有统计学意义（P＜0.05）。两组均有少部分患者出现轻度红斑反应，均在治疗后自行缓解，
无其他严重不良反应发生。联合组AMMC细胞黑素合成量为显著高于常规组，差异有统计学意义（P ＜0.05）。结论：卤米松
乳膏+NB-UVB+复方白芷酊对进展期白癜风患者疗效显著，能够提高AMMC细胞黑素合成量，有效促进白斑消退，缓解其临床病
症，值得临床推广与应用。

Abstract:
Abstract: Objective To investigate the effect of narrow-band ultraviolet B (NB-UVB) combined with compound angelica
dahurica tincture and halometasone cream on on the efficacy of vitiligo and melanin synthesis of amelanotic melanocytes
(AMMC) in the outer root sheath of hair follicles in patients with progressive vitiligo. Methods 70 patients with progressive
vitiligo who visited the dermatological department of our hospital between December 2016 and March 2019 were randomly
divided into the conventional group (35 cases) and the combined group (35 cases). The conventional group was treated with
halometasone cream +NB-UVB, while the combined group was treated with compound dahurian angelica tincture on the basis
of the conventional group. All patients were treated continuously for 24 weeks. The curative effects, the occurrence of adverse
reactions and in the two groups were observed and compared. Results After 12 weeks of treatment, there was no signifi cant
difference in the total effective rate between the combined group and the conventional group (82.86% vs 68.57%, P ＞0.05). At
24 weeks of treatment, the total effective rate in the combined group was higher than that in the conventional group (97.14%
vs 80.00%, P ＜0.05). A small number of patients in both groups developed mild erythema reaction, which were relieved after
treatment without other serious adverse reactions. The amount of melanin synthesis in AMMC cells in the combined group was
signifi cantly higher than that in the conventional group, and the difference was statistically signifi cant(P ＜0.05). Conclusion
Halometasone cream +NB-UVB+ compound angelica dahurica tincture has a significant effect on patients with advanced
vitiligo. It can improve melanin synthesis of AMMC cells, effectively promote leukoplakia regression. It is worthy of clinical
promotion and application.

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更新日期/Last Update: 2020-04-28