[1]邓雨萌 综述,雷 霞 审校. 炎性反应在瘢痕疙瘩发生发展中的作用及机制研究[J].中国美容医学,2020,(4):167-169.
　DENG Yu-meng,LEI Xia. The Role and Mechanism of Infl ammatory Responses in the Development of Keloid[J].Medical Aesthetics and Beauty,2020,(4):167-169.
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 炎性反应在瘢痕疙瘩发生发展中的作用及机制研究
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年4期
页码:
167-169
栏目:
出版日期:
2020-04-28

文章信息/Info

Title:
 The Role and Mechanism of Infl ammatory Responses in the Development of Keloid
文章编号:
1008-6455（2020）04-0167-03
作者:
 邓雨萌 综述; 雷 霞 审校
Author(s):
 DENG Yu-meng;  LEI Xia
关键词:
 ; [关键词]瘢痕疙瘩; 炎症反应; 成纤维细胞; 细胞因子
Keywords:
 ; Key words: keloid;  infl ammatory response;  fi broblasts;  cytokines
分类号:
R619+.6
文献标志码:
A
摘要:
[摘要]瘢痕疙瘩即一种过度生长的异常瘢痕组织，一般是在伤口愈合后形成的，通常具有较高的复发性，其早期通常伴有炎
性浸润区，这些炎性浸润区的炎症反应会在一定程度上促使成纤维细胞的过度增殖、成纤维细胞产物的增多及一些与炎性反
应相关的细胞因子的高表达，故瘢痕疙瘩与炎症反应有着密不可分的关系。近年来研究瘢痕疙瘩的炎性反应成为瘢痕疙瘩发
病及治疗研究的一大方向。本文从炎性反应所导致的成纤维细胞的增殖过度，以及与成纤维细胞增生和炎性反应相关细胞的
因子，例如：PDGF、TGF-β、IGF-1、HIF-1和过度增殖的成纤维细胞所分泌的胶原蛋白导致的代谢异常这三大方面来阐述瘢
痕疙瘩与炎性反应的相关性，从而进一步说明炎性反应在瘢痕疙瘩发展中的作用及机制。

Abstract:
Abstract: Keloid is an abnormally growing scar tissue that is usually formed after wound healing. It usually has a high
recurrence.It is also usually accompanied by infl ammatory infi ltration areas in the early stage. The infl ammatory response in
these infl ammatory infi ltration areas will promote the excessive proliferation of fi broblasts, the increase of fi broblast products,
and the high expression of some cytokines related to the infl ammatory response to a certain extent. Therefore, keloids have an
inseparable relationship with infl ammation. In recent years, researches on the infl ammatory response of keloids have become
a major direction for the research on the pathogenesis and treatments of keloids. Through this hot spot, this article will focus
on the excessive proliferation of fi broblasts caused by infl ammatory reactions and factors related to fi broblast proliferation and
infl ammatory responses, such as: PDGF, TGF-β, IGF-1, HIF -1 and metabolic abnormalities caused by collagen secreted by
overgrowthed fi broblasts to explain the correlation between keloid and infl ammatory response, and further explain the role and
mechanism of infl ammatory response in keloid development.

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更新日期/Last Update: 2020-05-14