[1] 杨芝香,康定华. 窄谱中波紫外线对白癜风患者血清维生素D水平的影响[J].中国美容医学,2020,(6):42-44.
　 YANG Zhi-xiang,KANG Ding-hua. Influence of Narrow-band Ultraviolet B on Serum Vitamin D Levels forPatients with Vitiligo[J].Medical Aesthetics and Beauty,2020,(6):42-44.
点击复制

 窄谱中波紫外线对白癜风患者血清维生素D水平的影响
()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年6期
页码:
42-44
栏目:
出版日期:
2020-06-10

文章信息/Info

Title:
 Influence of Narrow-band Ultraviolet B on Serum Vitamin D Levels for
Patients with Vitiligo
文章编号:
1008-6455（2020）06-0042-03
作者:
 杨芝香1; 康定华2
Author(s):
 YANG Zhi-xiang1; KANG Ding-hua2
关键词:
 [关键词]窄谱中波紫外线; 白癜风; 维生素D; 白癜风面积严重性指数; 色素沉着
Keywords:
 Key words: narrow-band-UVB;  vitamin D;  vitiligo;  vitiligo area severity index; pigmentation
分类号:
R758.4+1
文献标志码:
A
摘要:
[摘要]目的：研究窄谱中波紫外线（Narrow-band ultraviolet B,NB-UVB）治疗白癜风患者的血清维生素D水平及其与NBUVB
诱导色素沉着的相关性。方法：选取笔者医院2015年6月-2018年9月收治的90例白癜风患者为观察组，同时选定健康人群
20例为对照组。使用NB-UVB每周2次，持续24周。在第0周、第12周和第24周测量25-羟基维生素D水平。通过酶联免疫吸附
实验（Enzyme-linked immuno sorbent assay,ELISA）测定血清维生素D水平。在第0周、24周记录白癜风面积严重性指数
（Vitiligo Area Severity Index,VASI）。结果：观察组25-羟基维生素D（第0周）的平均水平显著低于对照组，第12周和
第24周患者血清中25-羟基维生素D的水平显著提高，观察组在治疗24周后显示VASI评分显著降低。结论：NB-UVB治疗可提高
白癜风患者血清维生素D水平，这可能在NB-UVB诱导的色素沉着中起重要作用，但NB-UVB诱导的色素沉着和维生素D在白癜风
中的完整机制需要进一步研究。

Abstract:
Abstract: Objective We aim to investigate the influence of NB-UVB phototherapy on vitamin D in patients with vitiligo and
their correlation with pigmentation induced by NB-UVB. Methods Ninety patients with vitiligo treated in our hospital from
June 2015 to September 2018 were selected as the observation group,and twenty healthy patients were selected as the control
group. Patients with vitiligo were treated with NB-UVB twice weekly for 24 weeks. Levels of 25-hydroxyvitamin D were
measured at weeks 0,12，and 24.Vitamin D levels were measured by Enzyme-linked immuno sorbent assay （ELISA）.Vitiligo
Area Severity Index （VASI） was recorded at weeks 0 and 24. Results The mean baseline level of 25-hydroxyvitamin D
（at 0 week） was significantly lower in patients than the control group. Levels of 25-hydroxyvitamin D in patients at week
12 and 24 were significantly increased,and VASI score was significantly decreased in patients after 24 weeks of treatment.
Conclusion NB-UVB therapy can improve serum vitamin D level in vitiligo patients,which may play an important role in
NB-UVB -induced pigmentation,but the complete mechanisms of NB-UVB -induced pigmentation and vitamin D in vitiligo
needs further study.

相似文献/References:

[1]陈 雪 综述,吴 皞 徐漫远 闵仲生审校. 火针治疗在损容性皮肤病中的应用[J].中国美容医学,2018,(04):155.
　CHEN Xue,WU Hao,XU Man-yuan,et al. The Application of Fire-Needle Therapy in Cosmetic Dermatosis[J].Medical Aesthetics and Beauty,2018,(6):155.
[2]郑羽宇,杨书平,戴 婷,等. 皮肤原位再生医疗技术联合微针导入治疗白癜风疗效观察[J].中国美容医学,2018,(07):97.
　ZHENG Yu-yu,YANG Shu-ping,DAI Ting,et al. The Clinical Observation of Skin Situ Regeneration Medical Technique Combined with Microneedle Introduction Technology in the Treatment of Vitiligo[J].Medical Aesthetics and Beauty,2018,(6):97.
[3]薛 梅,张德利,刁庆春,等. 丹参酚酸B对过氧化氢引起的黑素细胞凋亡的保护作用研究[J].中国美容医学,2019,(06):64.
　XUE Mei,ZHANG De-li,DIAO Qing-chun,et al. Study on Magnesium Tanshinoate B Alleviated H2O2-induced Apoptosis in Human Epidermal Melanocytes[J].Medical Aesthetics and Beauty,2019,(6):64.
[4]赵莲英,刘冬青,刘文利. 308nm准分子激光联合驱白巴布斯片对面部白癜风患者的美容修复效果研究[J].中国美容医学,2020,(2):60.
　ZHAO Lian-ying,LIU Dong-qing,LIU Wen-li. Study on the Cosmetic Repair Effect in Patients with Facial Vitiligo by Using 308nmExcimer Laser Combined with Qubaibasi Tablets[J].Medical Aesthetics and Beauty,2020,(6):60.
[5] 吉 津,章若画,严 炯,等. 他克莫司联合复方甘草酸苷片对白癜风稳定期患者血清Th1/Th2型细胞因子水平的影响[J].中国美容医学,2020,(5):48.
　 JI Jin,ZHANG Ruo-hua,YAN Jiong,et al. The Effect of Tacrolimus Combined with Glycyrrhizic Acid Tablet on the Level of Th1/Th2 Cytokines in Patients with Stable Vitiligo[J].Medical Aesthetics and Beauty,2020,(6):48.
[6] 王云颖 综述,康晓静 审校. 自噬在免疫性皮肤病中的研究进展[J].中国美容医学,2020,(7):180.
　 WANG Yun-ying,KANG Xiao-jing. Emerging Progress of Autophagy in Autoimmune Skin Diseases[J].Medical Aesthetics and Beauty,2020,(6):180.
[7] 丁 钰,黄忠奎,胡秀玲. 自身免疫性甲状腺疾病患者血清25-（OH）D表达水平与白癜风的相关性分析[J].中国美容医学,2020,(10):111.
　 DING Yu,HUANG Zhong-kui,HU Xiu-ling. Correlation between Serum 25-(OH)D Expression Level and Vitiligo in Patients withAutoimmune Thyroid Disease[J].Medical Aesthetics and Beauty,2020,(6):111.
[8] 林士伟,魏茗蕾,孔 静. 晕痣患者中白癜风发生状况及其危险因素分析[J].中国美容医学,2020,(12):40.
　 LIN Shi-wei,WEI Ming-lei,KONG Jing. Analysis of the Occurrence of Vitiligo and its Risk Factors in Patients with Syncope[J].Medical Aesthetics and Beauty,2020,(6):40.
[9] 任 虎. 毫火针辅助308nm准分子光联合他克莫司软膏对白癜风患者疗效及免疫功能的影响[J].中国美容医学,2021,(3):102.
　 REN Hu. Effect of Millifire Needle Assisted 308nm Excimer Laser Combine with TacrolimusOintment on Immune Function of Patients with Vitiligo[J].Medical Aesthetics and Beauty,2021,(6):102.
[10] 张明平,张天成. 刺络拔罐法联合全虫方加减治疗白癜风60例疗效观察[J].中国美容医学,2021,(3):105.
　 ZHANG Ming-ping,ZHANG Tian-cheng. Curative Effect Observation on 60 Cases of Vitiligo Treated by Pricking Collateralsand Cupping Combined with the Addition and Subtraction of Quanchong Formula[J].Medical Aesthetics and Beauty,2021,(6):105.

更新日期/Last Update: 2020-06-24