[1] 李 越 综述,刘 浥 吴信峰 审校. 先天性巨痣的治疗进展[J].中国美容医学,2020,(6):181-185.
　 LI Yue,LIU Yi,WU Xin-feng. Progress of Treatment on Giant Congenital Melanocytic Nevus[J].Medical Aesthetics and Beauty,2020,(6):181-185.
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 先天性巨痣的治疗进展
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年6期
页码:
181-185
栏目:
出版日期:
2020-06-10

文章信息/Info

Title:
 Progress of Treatment on Giant Congenital Melanocytic Nevus
文章编号:
1008-6455（2020）06-0181-05
作者:
 李 越 综述; 刘 浥 吴信峰 审校
Author(s):
 LI Yue; LIU Yi; WU Xin-feng
关键词:
 [关键词]先天性巨痣; 恶性黑素瘤; 综合性治疗; 个体化
Keywords:
 Key words:giant congenital melanocytic nevus;  malignant melanoma;  comprehensive treatment;  individualization
分类号:
R739.5
文献标志码:
A
摘要:
[摘要]先天性巨痣(Giant Congenital Melanocytic Nevus，GCMN)常定义为成年后直径大于20cm的先天性色素痣。其发病机
理目前多认为是黑素母细胞于妊娠5～25周内，由神经嵴向皮肤及软脑膜的迁移异常所致。巨痣不但严重影响外观（典型表
现呈“衬衫状”、“套衣状”），且常伴溃疡、瘙痒、疼痛、少汗、多毛等表现，造成患者及其家属的巨大痛苦；此外，巨
痣尚可继发恶性黑素瘤（5%～10%）及神经皮肤黑变病（neurocutaneous melanosis,NCM）。国内外治疗巨痣方法各异，包
括传统的手术、激光、磨削、剥脱以及新近的Integra人工真皮、体外培养自体表皮移植（CEA）、脱细胞真皮基质（ADM）
等。上述方法各有利弊，临床上常需采取综合治疗，制定个体化方案。

Abstract:
Abstract: The most common definition of Giant Congenital Melanocytic Nevus (GCMN) is the nevus whose diameter is
greater than twenty centimeters in adults.The pathogenesis of GCMN is now widely considered as an abnormal migration of
melanocytic blast cells from neural crest to leptomeningea and skin during the fifth to twenty fifth pregnancy.GCMN not only
severely affects appearance(typical manifestations is “garment” or “T-shirt”shapes),but also brings about a series of clinical
manifestations like ulcer,itch,pain,less sweat and much hair, making the patients and their family members suffer a lot.In
addition,GCMN can transfer to melanoma(5%-10%) and NCM(neurocutaneous melanosis). There have been many methods of
treatments including conventional surgery,laser,dermabrasion,and chemical peel,and some novel methods like Integra artificial
dermis,cultured epidermal autograft and artificial dermis matrix and so on.Every method above has its own advantages and
disadvantages,needing us to take comprehensive treatments and make individualized plans.

相似文献/References:

[1]郑舒丹,程诗萌,董亚兵,等. GNB2L1对恶性黑素瘤细胞增殖和迁移的影响[J].中国美容医学,2019,(06):59.
　ZHENG Shu-dan,CHENG Shi-meng,DONG Ya-bing,et al. Effects of GNB2L1 on Proliferation and Migration of Malignant Melanoma Cells[J].Medical Aesthetics and Beauty,2019,(6):59.
[2] 郎中亮,钟晓红,汪 凯,等. 负压创面治疗技术在恶性黑素瘤腹股沟淋巴结清扫术中的应用价值[J].中国美容医学,2020,(8):72.
　 LANG Zhong-liang,ZHONG Xiao-hong,WANG Kai,et al. The Effect of Negative Pressure Wound Treatment in Inguinal Lymph Node Dissectionfor Malignant Melanoma[J].Medical Aesthetics and Beauty,2020,(6):72.

更新日期/Last Update: 2020-06-24