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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:

期数:

2020年7期

页码:

36-38

栏目:

出版日期:

2020-07-10

文章信息/Info

Title:

 Observation on Effi ccacy of Sensitivity Easing Cream Combination Tacrolimus
Ointment for the Treatment of Facial Glucocorticoid Dependent Dermatitis

文章编号:

1008-6455（2020）07-0036-03

作者:

 张 楠; 何 弘; 王惠琳; 谭 红; 李东晓

Author(s):

 ZHANG Nan; HE Hong; WANG Hui-lin; TAN Hong; LI Dong-xiao

关键词:

 [关键词]舒敏保湿特护霜; 0.03%他克莫司软膏; 面部糖皮质激素依赖性皮炎; 皮肤无创检测; 皮肤屏障

Keywords:

 Key words: sensitivity easing cream;  0.03% tacrolimus ointment;  facial glucocorticoid dependent dermatitis;  noninvasive skintest;  skin barrier

分类号:

R758.22

文献标志码:

A

摘要:

[摘要]目的：观察舒敏保湿特护霜联合他克莫司软膏治疗面部糖皮质激素依赖性皮炎的临床疗效。方法：选择56例女性
面部糖皮质激素依赖性皮炎患者随机分成两组，治疗组：给予口服抗组胺药物氯雷他定，面部红光照射治疗，外用0.03%
他克莫司软膏，联合外用舒敏保湿特护霜；对照组：给予口服抗组胺药物氯雷他定，面部红光照射治疗及外用0.03%他克
莫司软膏。观察两组治疗效果，皮肤生理功能指标及复发情况。结果：治疗组治疗30d后有效率为71.4%，高于对照组的
42.8%，差异具有统计学意义。治疗组治疗15d后皮肤含水量（26.45±1.82）%，透皮失水量（21.04±2.0）g/(cm2·h)以
及皮脂含量（93.06±1.94）μg/cm2，较对照组明显改善；治疗组治疗30d后皮肤含水量（28.60±1.55）%，透皮失水量
（18.58±1.87）g/(cm2·h)以及皮脂含量（95.44±1.98）μg/cm2较对照组明显改善。随访中治疗组复发率低于对照组，且
差异具有统计学意义。结论：舒敏保湿特护霜联合他克莫司软膏治疗面部糖皮质激素依赖性皮炎疗效明显，有助于皮肤屏障
功能恢复，并且有助于防止复发。

Abstract:

Abstract: Objective To observe the clinical effect of sensitivity easing cream combination 0.03% tacrolimus ointment for the
treatment of glucocorticoid dependent dermatitis. Methods A total of 56 female patients with facial glucocorticoid dependent
dermatitis were recruited and divided into two groups randomly in our study. Patients in the study group received oral treatment
with topical sensitivity easing cream, topical treatment with 0.03% tacrolimas, anti-histamine drug clarityne, and physical
treatment with red light, while Patients in the control group received oral treatment with anti-histamine drug clarityne, topical
treatment with 0.03% tacrolimas, and physical treatment with red light. Results After 30-day treatment, the effective rate was
71.4% in the treatment group, higher than that in the control group (42.8%), the differences were statistically signifi cant. After
15-day treatment in the treatment group, water content（26.45±1.82）%, transepidermal waterloss（21.04±2.02）g/(cm2?h)
and oil content（93.06±1.94）μg/cm2 were significantly different with those in the control group. After 30-day treatment
in the treatment group, water content（28.60±1.55）%, transepidermal waterloss（18.58±1.87）g/(cm2?h) and oil content
（95.44±1.98）μg/cm2 were signifi cantly different with those in the control group. The recurrence rate in the treatment group
was lower than that in the control group, and the difference was statistically signifi cant. Conclusion Sensitivity easing cream
combination tacrolimus ointment was effective for the treatment of facial glucocorticoid dependent dermatitis, helping to
rebuild the skin barrier and to prevent recurrence.

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更新日期/Last Update: 2020-07-22