[1] 罗伟华,蒋 亮,贺万强,等. 富血小板纤维蛋白修复难愈性骨外露创面疗效探讨[J].中国美容医学,2020,(7):71-73.
　 LUO Wei-hua,JIANG Liang,HE Wan-qiang,et al. Effect of Platelet-rich Fibrin in Repairing Refractory Bone Exposure Wounds[J].Medical Aesthetics and Beauty,2020,(7):71-73.
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 富血小板纤维蛋白修复难愈性骨外露创面疗效探讨
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年7期
页码:
71-73
栏目:
出版日期:
2020-07-10

文章信息/Info

Title:
 Effect of Platelet-rich Fibrin in Repairing Refractory Bone Exposure Wounds
文章编号:
1008-6455（2020）07-0071-03
作者:
 罗伟华; 蒋 亮; 贺万强; 王 林; 陈建利; 高小春
Author(s):
 LUO Wei-hua; JIANG Liang; HE Wan-qiang; WANG Lin; CHEN Jian-li; GAO Xiao-chun
关键词:
 [关键词]富血小板纤维蛋白; 骨外露; 慢性创面; 难愈性创面; 藻酸盐敷料
Keywords:
 Key words: platelet-rich fi brin(PRF);  bone exposure;  chronic wounds;  refractory wound;  alginate dressing
分类号:
R622
文献标志码:
A
摘要:
[摘要]目的：探讨富血小板纤维蛋白(Platelet-rich fibrin，PRF）修复难愈性骨外露创面的临床疗效。方法：将2016年4
月-2019年3月在达州市中心医院烧伤整形科住院和伤口中心门诊治疗的骨外露60例患者随机分为实验组（PRF治疗）和对照
组（藻酸盐敷料+表皮生长因子治疗），比较两组治疗后2周的创面肉芽组织覆盖情况、肉芽组织覆盖全部创面时间、换药次
数。结果：实验组治疗2周后骨外露面积缩小（4.6±1.12）cm2明显高于对照组（3.6±0.61）cm2，肉芽组织全覆盖时间为
（20.5±6.15）d少于对照组（37.4±9.13）d，换药次数（3.83±1.09）次低于对照组的（15.86±4.28）次，差异均有统
计学意义（P ＜0.05）。结论：PRF能明显促进肉芽组织生长，缩短骨外露创面肉芽覆盖时间，减少换药次数，可以作为骨外
露创面的治疗方法之一，值得临床推广应用。

Abstract:
Abstract: Objective To investigate the clinical therapeutic effect of platelet-rich fibrin(PRF) in repairing refractory bone
exposure wounds. Methods From April 2016 to March 2019, Sixty patients with bone exposure treated in the department of
burn and plastic surgery of Dazhou Central Hospital were randomly divided into the experimental group (PRF treatment) and
the control group (alginate dressing + epidermal growth factor treatment). The granulation tissue coverage, granulation tissue
coverage time and dressing change times were compared between the two groups 2 weeks after treatment. Results After
2 weeks of treatment, the bone exposure area of the experimental group decreased (4.6±1.12)cm2, which was significantly
higher than that of the control group (3.6±0.61)cm2, the granulation tissue covered time was (20.5±6.15)d, which was shorter
than (37.4±9.13)d in the control group, the frequency of dressing change (3.83±1.09) was lower than that of control group
(15.86±4.28), the differences were statistically signifi cant(P ＜0.05). Conclusion PRF can signifi cantly promote the growth
of granulation tissue, shorten the time of granulation coverage on open refractory bone wounds, and reduce the frequency
of dressing changes. It can be used as one of the treatment methods for exposedrefractory bone wounds and is worthy of the
clinical application and promotion.

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更新日期/Last Update: 2020-07-22