[1] 张文瑞,许春姣,郭怡婷,等. 龙血素B对角质形成细胞增殖和迁移的影响[J].中国美容医学,2020,(8):31-34.
　 ZHANG Wen-rui,XU Chun-jiao,GUO Yi-ting,et al. The Effects of Loureirin B on Proliferation and Migration of HaCaT Cells[J].Medical Aesthetics and Beauty,2020,(8):31-34.
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 龙血素B对角质形成细胞增殖和迁移的影响
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年8期
页码:
31-34
栏目:
出版日期:
2020-08-10

文章信息/Info

Title:
 The Effects of Loureirin B on Proliferation and Migration of HaCaT Cells
文章编号:
1008-6455（2020）08-0031-03
作者:
 张文瑞; 许春姣; 郭怡婷; 孙煜梅
Author(s):
 ZHANG Wen-rui; XU Chun-jiao; GUO Yi-ting; SUN Yu-mei
关键词:
 [关键词]龙血素B; 角质形成细胞; 细胞增殖; 创面愈合; 再上皮化
Keywords:
 Key words: Loureirin B;  keratinocytes;  cell proliferation;  wound healing;  re-epithelialization
分类号:
Q343.6
文献标志码:
A
摘要:
[摘要]目的：观察龙血素B（Loureirin B，LB）对体外培养人永生化角质形成细胞（Immortalized human keratinocytes，
HaCaT）增殖和迁移的影响，探究LB是否促进创面愈合再上皮化过程。方法：噻唑蓝（MTT）法检测不同浓度LB对体外培养
HaCaT细胞增殖的影响，细胞划痕实验分析LB对HaCaT细胞迁移的影响。结果：5、10、25、50μg/ml LB呈剂量依赖性抑制
HaCaT细胞增殖（P ＜0.05），10、25μg/ml LB呈剂量依赖性抑制划痕愈合及HaCaT细胞迁移（P ＜0.01）。结论：LB具有显
著抑制HaCaT细胞增殖和迁移的作用，提示LB可能抑制创面愈合再上皮化过程。

Abstract:
Abstract: Objective To observe the effects of Loureirin B (LB) on proliferation and migration of human immortalized human
keratinocytes (HaCaT) in vitro, and explore whether LB can promote the re-epithelialization process of wound healing.
Methods The effects of different concentrations of LB on proliferation of HaCaT cells were evaluated by MTT assay, and
the effects on migration of HaCaT cells were analyzed by scratch wound assays. Results 5, 10, 25, 50μg/ml LB inhibited
proliferation of HaCaT cells in a dose-dependent manner (P ＜0.05). 10, 25μg/ml LB suppressed scratch closure and migration
of HaCaT cells in a dose-dependent manner (P ＜0.01). Conclusion LB can signifi cantly inhibit proliferation and migration of
HaCaT cells, suggesting that LB may have an inhibitory effect on the re-epithelialization process of wound healing.

相似文献/References:

[1]楚菲菲,王大雷,闫 伦,等.阻断Notch信号的角质形成细胞对成纤维细胞增殖及分泌功能的影响研究[J].中国美容医学,2018,(08):73.
　CHU Fei-fei,WANG Da-lei,YAN Lun,et al.Differences of Cell Proliferation and Secretion in Fibroblasts Co-culture with Notch Signaling Occured Keratinocytes[J].Medical Aesthetics and Beauty,2018,(8):73.
[2]邹雪莲 胡 雯综述,康晓静审校.角质形成细胞与白癜风发病机制的相关研究进展[J].中国美容医学,2021,(12):178.
　ZOU Xue-lian,HU Wen,KANG Xiao-jing.Research Progress of Keratinocytes and the Pathogenesis of Vitiligo[J].Medical Aesthetics and Beauty,2021,(8):178.

更新日期/Last Update: 2020-08-26