[1] 雄婉玲,党连强,卢 珊.血必净注射液对重度烧伤患者发生脓毒症的预防作用及对炎性因子的影响[J].中国美容医学,2020,(10):81-85.
　 XIONG Wan-ling,DANG Lian-qiang,LU Shan. The Preventive Effect of Xuebijing Injection on Sepsis in Severe Burn Patients and itsInfluence on Inflammatory Factors[J].Medical Aesthetics and Beauty,2020,(10):81-85.
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血必净注射液对重度烧伤患者发生脓毒症的预防作用及对炎性因子的影响
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年10期
页码:
81-85
栏目:
出版日期:
2020-10-10

文章信息/Info

Title:
 The Preventive Effect of Xuebijing Injection on Sepsis in Severe Burn Patients and its
Influence on Inflammatory Factors
文章编号:
1008-6455（2020）10-0081-04
作者:
 雄婉玲; 党连强; 卢 珊
Author(s):
 XIONG Wan-ling; DANG Lian-qiang; LU Shan
关键词:
 [关键词]血必净注射液; 重度烧伤; 脓毒症; 血清炎性因子; 急性生理与慢性健康状况评分; 全身性感染相关性器官功能衰竭评分; 药物不良反应
Keywords:
 Key words: Xuebijing injection;  severe burn;  sepsis;  serum inflammatory factors;  acute physiology and chronic healthevaluation (APACHE-Ⅱ);  sepsis-related organ failure assessment(SOFA);  adverse drug reactions
分类号:
R644
文献标志码:
A
摘要:
[摘要]目的：分析血必净注射液预防重度烧伤患者并发脓毒症的临床价值，及其对炎性因子水平的影响，为重度烧伤患者治
疗方案选择提供参考。方法：选择2016年2月-2019年1月笔者医院收治的重度烧伤患者108例，按照入组顺序编号，单号设为
对照组共计54例，双号设为观察组共计54例。两组患者均行烧伤患者常规治疗，对照组予以常规烧伤系统化处理，观察组在
对照组治疗基础上再予以血必净注射液治疗。两组患者均连续治疗10d。采集两组患者治疗前后静脉血检测血清炎症因子[白
细胞介素6(IL-6)、白细胞介素8(IL-8)及白细胞介素10(IL-10)、肿瘤坏死因子-α（TNF-α）]水平并行组间比较。对两组
患者治疗前后的急性生理与慢性健康状况Ⅱ评分（Acute physiology and chronic health evaluation Ⅱ，APACHE-Ⅱ）、
全身性感染相关性器官功能衰竭评分（Sepsis-related organ failure assessment，SOFA）进行测评并行组间比较。治疗
期间全程监测患者是否出现脓毒症征象并完善相关检查，比较组间脓毒症发生率。收集两组患者治疗期间药物不良反应情
况。结果：两组患者入组时血清IL-6、IL-8、IL-10、TNF-α及CRP比较差异无统计学意义（P ＞0.05）；治疗后两组患者
IL-6、IL-8、TNF-α及CRP上述指标均较治疗前明显下降，且观察组低于对照组，差异有统计学意义（P ＜0.05）；对照
组治疗前后血清IL-10比较差异无统计学意义（P ＞0.05）；观察组治疗后血清IL-10较治疗前上升，且高于对照组，差异
有统计学意义（P ＜0.05）。两组患者入组时APACHE-Ⅱ评分、SOFA评分比较差异无统计学意义（P ＞0.05），治疗后两组
患者APACHE-Ⅱ评分、SOFA评分均较治疗前明显下降，且观察组低于对照组，差异有统计学意义（P ＜0.05）。治疗期间观
察组脓毒症发生率低于对照组，差异有统计学意义（P ＜0.05）。两组患者治疗期间药物不良反应发生率比较差异无统计学
意义（P ＞0.05）。结论：血必净注射液可有效降低重度烧伤患者血清炎症因子水平，预防患者并发脓毒症，且不增加患者
的药物不良反应，安全高效具有较高的临床价值。

Abstract:
Abstract: Objective To analyze the clinical value of Xuebijing injection in the prevention of sepsis in severe burn patients,
and its influence on the level of inflammatory factors, so as to provide a reference for the treatment of severe burn patients.
Methods 108 patients with severe burn from February 2016 to January 2019 were selected and numbered accorded to the
order of enrollment. 54 patients in the control group .The observation group were in the single number and the double number
respectively. The patients in the two groups were treated with routine burn treatment. The control group were treated with
systemic burn treatment. The patients in the observation group were treated with Xuebijing Injection on the basis of the
treatment in the control group. Both groups were treated for 10 days. The serum inflammatory factors (IL-6, IL-8, IL-10,
TNF-α) were measured before and after treatment in the venous blood of the two groups. The acute physiological and chronic
health evaluation Ⅱ (APACHE-Ⅱ) and sepsis-related organ failure assessment (SOFA) of the two groups before and after
treatment were evaluated and compared. During the treatment period, the patients were monitored for signs of sepsis,
and the relevant examinations were improved to determine whether sepsis occurred. The incidence of sepsis among the
groups was compared. Adverse drug reactions were collected and compared between the two groups. Results There was
no significant difference in serum IL-6, IL-8, IL-10, TNF-α and CRP between the two groups before treatment (P ＞0.05).
After treatment, the above indexes of IL-6, IL-8, TNF-α and CRP in the two groups were significantly lower than those before
treatment, and the patients in the observation group were lower than those in the control group, the differences were statistically
significant(P ＜0.05). There was no significant difference in serum IL-10 before and after treatment in the control group (P ＞0.05).
The level of IL-10 in the observation group increased after treatment, and was higher than that in the control group (P ＜0.05).
There was no significant difference in Apache-Ⅱ score and SOFA score between the two groups (P ＞0.05). After treatment,
Apache-Ⅱ score and SOFA score of the two groups were significantly lower than before treatment, and the observation group
was lower than that of the control group (P ＜0.05). The incidence of sepsis in the observation group was lower than that in
the control group (P ＜0.05). There was no significant difference in adverse drug reactions between the two groups (P ＞0.05).
Conclusion Xuebijing injection can effectively reduce the level of serum inflammatory factors in patients with severe burns,
prevent the patients from sepsis, and do not increase the adverse drug reactions of patients. It is safe and effective with high
clinical value.

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更新日期/Last Update: 2020-10-30