[1] 沈秀兰. 复方甘草酸苷联合依巴斯汀治疗面部激素依赖性皮炎对血清IL-4水平及皮肤屏障功能的影响分析[J].中国美容医学,2020,(11):66-69.
  SHEN Xiu-lan. Effects of Compound Glycyrrhizin Combined with Ebastine on Serum IL-4 Level andSkin Barrier Function in Patients with Facial Hormone-dependent Dermatitis[J].Medical Aesthetics and Beauty,2020,(11):66-69.
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 复方甘草酸苷联合依巴斯汀治疗面部激素依赖性皮炎对血清IL-4水平及皮
肤屏障功能的影响分析
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年11期
页码:
66-69
栏目:
出版日期:
2020-11-10

文章信息/Info

Title:
 Effects of Compound Glycyrrhizin Combined with Ebastine on Serum IL-4 Level and
Skin Barrier Function in Patients with Facial Hormone-dependent Dermatitis
文章编号:
1008-6455(2020)11-0066-04
作者:
 沈秀兰
Author(s):
 SHEN Xiu-lan
关键词:
 [关键词]面部激素依赖性皮炎复方甘草酸苷依巴斯汀疗效白细胞介素-4皮肤屏障功能
Keywords:
 Key words: facial hormone-dependent dermatitiscompound glycyrrhizin ebastineclinical effi cacyinterleukin-4skin barrier function
分类号:
R758.22
文献标志码:
A
摘要:
[摘要]目的:分析复方甘草酸苷联合依巴斯汀治疗面部激素依赖性皮炎(HDD)对血清白细胞介素(IL-4)水平及皮肤屏障
功能的影响。方法:选择笔者医院收治的100例面部HDD患者,随机分为对照组与治疗组,每组50例。对照组采用依巴斯汀治
疗,治疗组采用复方甘草酸苷联合依巴斯汀治疗,比较两组临床疗效、皮损面积、血清生化指标、皮肤屏障功能、不良反
应及随访情况差异。结果:经治疗,治疗组临床总有效率为84%,显著高于对照组的62%(P <0.05);治疗后,两组皮损面
积呈明显下降趋势,组内差异显著(P <0.05);治疗组治疗2、3、4周时的皮损面积均显著小于对照组(P <0.05);
治疗后,两组血清生化指标[IL-4、免疫球蛋白-E(IgE)及干扰素-γ(IFN-γ)]水平均显著降低(P <0.05),且
治疗组的I L - 4 、I g E 及I N F - γ 水平均显著低于对照组(P < 0 . 0 5 ) ;治疗后,两组局部皮肤屏障功能中油脂水
平显著提高(P <0 . 0 5),经皮水分丢失值(TEWL)、红斑量显著降低,且治疗组的油脂水平显著高于对照组(P
<0.05),TEWL、红斑量显著低于对照组(P <0.05);治疗期间,两组不良反应发生率比较差异无统计学意义(P
>0.05),停药后4周随访,治疗组复发率显著低于对照组(P <0.05)。结论:复方甘草酸苷联合依巴斯汀治疗面部
HDD疗效显著,可快速缩小皮损面积,改善患者炎症状态、免疫功能及皮肤屏障功能,复发率低,值得临床推广。
Abstract:
Abstract: Objective To analyze the effects of compound glycyrrhizin combined with ebastine on serum interleukin (IL-4)
level and skin barrier function in patients with facial hormone-dependent dermatitis (HDD). Methods 100 patients with facial
HDD admitted to our hospital were selected and randomly divided into control group and treatment group, with 50 cases in
each group. Control group was given ebastine, and treatment group was given compound glycyrrhizin combined with ebastine.
The clinical efficacy, skin lesion area, serum biochemical markers, skin barrier function, adverse reactions and follow-up
condition were compared between the two groups. Results After treatment, the total clinical effective rate in treatment group
was signifi cantly higher than that in control group (84% vs 62%) (P <0.05). After treatment, the skin lesion area in the two
groups showed a signifi cant downward trend (P <0.05). The skin lesion area at 2, 3 and 4 weeks of treatment in treatment group
was signifi cantly lower than that in control group (P <0.05). After treatment, the levels of serum biochemical markers [IL-4,
immunoglobulin-E (IgE) and interferon-γ (IFN-γ)] were signifi cantly decreased in the two groups (P <0.05), and the levels of
IL-4, IgE and INF-γ in treatment group after treatment were signifi cantly lower than those in control group (P <0.05). After
treatment, the grease level in skin barrier function was signifi cantly increased in the two groups (P<0.05) while the transepidermal
water loss (TEWL) and erythema dose were significantly decreased, and the grease level in treatment group after treatment was
signifi cantly higher than that in control group (P<0.05) while the TEWL and erythema dose were signifi cantly lower than those in
control group (P<0.05). There was no signifi cant difference in the incidence rate of adverse reactions between the two groups during
treatment (P>0.05). At 4w follow-up after withdrawal, the recurrence rate in treatment group was signifi cantly lower than that in
control group (P <0.05). Conclusion Compound glycyrrhizin combined with ebastine has signifi cant effi cacy in the treatment
of facial HDD. And it can rapidly reduce the skin lesion area, improve the inflammatory states, immune function and skin
barrier function of patients, and it has a low recurrence rate, thus it is worthy of clinical promotion.

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更新日期/Last Update: 2020-11-24