1%吡美莫司乳膏联合多磺粘多糖乳膏治疗面部糖皮质激素依赖性<br />皮炎疗效观察<br />-《中国美容医学》

文章信息/Info

Title:: Clinical Efficacy of Topical Pimelimus Cream Combined with Mucopolysaccharide
Polysulfate Cream in Treating Corticosteroid Dependent Facial Dermatitis

Author(s):: TONG Hai-tao1; WU Qiao-fang2; Shehzad Gopee3; KAN Jing-bao4; YIN Zhi3

Keywords:: Key words:pimelimus; mucopolysaccharide polysulfate; glucocorticoid-dependent dermatitis; withdraw; clinical efficacy

摘要:: [摘要]目的：观察外用吡美莫司乳膏联合多磺粘多糖乳膏治疗面部糖皮质激素依赖性皮炎的有效性和安全性。方法：选
取2016年1月-2020年1月笔者科室就诊的面部糖皮质激素依赖性皮炎患者，随机分为联合组及对照组，联合组：患者外
用 1%吡美莫司乳膏与多磺粘多糖乳膏；对照组：患者单用1%吡美莫司乳膏，共4周。比较两组患者的疗效、不良反应及
复发情况等。结果：完成4周治疗后，联合组多项客观症状及自觉症状评分好转程度均优于对照组，且差异有统计学意
义（P ＜0.05），两组患者的复发率比较无统计学差异（P ＞0.05）。结论：1%吡美莫司乳膏联合多磺粘多糖乳膏治疗面部
糖皮质激素依赖性皮炎安全、有效。

Abstract:: Abstract: Objective To observe the efficacy and safety of topical pimelimus cream combined with mucopolysaccharide
polysulfate cream for the treatment of patients with facial glucocorticoid-dependent dermatitis. Methods Patients with facial
glucocorticoid-dependent dermatitis admitted to the author’s unit from January 2016 to January 2020 were selected and
randomly divided into the combined treatment group and the control group. Patients in the combined treatment group were
treated with topical application of 1% pimelimus cream and mucopolysaccharide polysulfate cream, while patients in the
control group were treated with 1% pimelimus cream alone, for 4 weeks.The curative effect, adverse reaction and recurrence
of the two groups were compared. Results After 4 weeks of treatment, scores of objective symptoms and conscious symptoms
in the combined treatment group were lower than those in the control group(P ＜0.05). And there was no significant statistical
difference in the recurrence rate of the two groups. Conclusion 1% pimelimus cream combined with mucopolysaccharide
polysulfate cream is safe and effective in the treatment of hormone-dependent facial dermatitis.