[1] 李雪丽,孙小云,尤加锐,等. Cynergy双波长激光联合普萘洛尔治疗婴幼儿浅表性血管瘤[J].中国美容医学,2021,(1):61-65.
　 LI Xue-li,SUN Xiao-yun,YOU Jia-rui,et al. Analysis of Therapeutic Effect of Cynergy Dual-wavelength Dye Laser Combinedwith Propranolol on Superficial Infantile Hemangioma[J].Medical Aesthetics and Beauty,2021,(1):61-65.
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 Cynergy双波长激光联合普萘洛尔治疗婴幼儿浅表性血管瘤
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年1期
页码:
61-65
栏目:
出版日期:
2021-01-10

文章信息/Info

Title:
 Analysis of Therapeutic Effect of Cynergy Dual-wavelength Dye Laser Combined
with Propranolol on Superficial Infantile Hemangioma
文章编号:
1008-6455（2021）01-0061-05
作者:
 李雪丽1; 2; 孙小云2; 尤加锐2; 裴 军2; 黄 平2; 黄 勇1
Author(s):
 LI Xue-li1; 2; SUN Xiao-yun2; YOU Jia-rui2; Pei Jun2; HUANG Ping2;  HUANG Yong1
关键词:
 [关键词]婴幼儿; 血管瘤; 治疗; 激光; 普萘洛尔
Keywords:
 Key words: infant;  hemangioma;  treatment;  laser;  propranolol
分类号:
R732.2
文献标志码:
A
摘要:
[摘要]目的：探讨585/1 064nm双波长激光联合普萘洛尔药物治疗婴幼儿浅表性血管瘤的疗效。方法：选取138例浅表性血管
瘤患儿为研究对象，分为激光治疗组（n ＝52）、口服药物治疗组（n ＝46）和联合治疗组（n ＝40）三组。三组患儿每月接
受复诊，随访6个月，记录患儿性别、年龄、瘤体部位、瘤体大小、医治时间、医治结果和不良反应。采用Achauer等的评
判标准进行疗效评价，同时详细记录治疗过程中每组患儿的不良反应。结果：联合治疗组的有效率97.5%,与激光治疗组的
96.2%、口服药物治疗组的95.7%比较，均无显著性差异（P ＞0.05）；联合治疗组的优良率92.5%，与激光治疗组的65.4%、
口服药物治疗组的78.3%相比，联合治疗组的优良率明显升高，且有显著性差异（P ＜0.05）；联合治疗组达到IV级优的比率
62.5%,与激光组治疗组的30.8%、口服药物治疗组的32.6%相比，联合治疗组疗效为优的患儿超过本组治疗人数一半，存在显
著性差异，且所需的治疗时间为（4.72±1.03）个月，时间明显短于激光治疗组的（6.65±1.46）个月、口服药物治疗组
的（6.83±1.44）个月，且有显著性差异（P ＜0.05）。三组治疗过程中少数患儿会出现轻微不良反应，如：皮肤水肿、水
疱、腹泻、皮疹等，但均未出现危及生命的严重并发症或不良反应。结论：585/1 064nm双波长激光与口服普萘洛尔治疗浅
表性婴幼儿血管瘤均能取得满意疗效，但两者联合治疗效果更佳且安全，也在一定程度上缩短了治疗时间。

Abstract:
Abstract: Objective To explore the effect 585/1 064nm double wavelength dye laser combined with propranolol in the
treatment of superficial infantile hemangioma. Methods 138 patients with superficial hemangioma were selected and divided
into three groups: laser treatment group (n =52), oral drug treatment group (n =46), and combined treatment group (n = 40). The
three groups of patients received monthly follow-up visits and were followed up for 6 months. The sex, age, tumor site, tumor
size, treatment time, treatment results, and adverse reactions of the children were recorded. Achauer et al. were used to evaluate
the efficacy and to record in detail the adverse reactions of each group of children during treatment. Results There was no
significant difference between the combination treatment group’s effective rate (97.5%), laser treatment group (96.2%),oral drug
treatment group (95.7%)(P ＞0.05).The excellent rate (92.5%) of the combination treatment group was compared with the laser
treatment group (65.4%) and the oral drug treatment group (78.3%), the excellent rate in the combination treatment
group was significantly increased, there was a difference (P ＜0.05).The ratio of the combination treatment group
achieving grade IV excellent (62.5%) and the laser treatment group (30.8%) compared with the oral drug treatment
group (32.6%), the children with better efficacy in the combined treatment group exceeded half of the number of
treatment in this group, there was a significant difference. And the required treatment time was (4.72±1.03) months , which
was significantly shorter than that in the laser treatment group (6.65±1.46) and the oral drug treatment group (6.83±1.44), and
there was a difference (P ＜0.05) . During the treatment of the three groups, a small number of children showed slight adverse
reactions such as skin edema,blisters,diarrhea,and rash,but none of them had serious life-threatening complications or adverse
reactions. Conclusion Both 585 /1 064nm dual-wavelength laser alone and oral propranolol alone can achieve satisfactory
results for superficial infantile hemangiomas, but the combination of the two for superficial infantile hemangiomas is safer and
better, and the treatment time is also certain to a lesser extent.

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更新日期/Last Update: 2021-02-02