[1] 钱 俐,缪亚军,余珊珊. 他克莫司软膏联合308准分子光治疗寻常型白癜风及对外周血CD4+/CD8+、IL-17、IL-22的影响[J].中国美容医学,2021,(1):82-85.
  QIAN Li,MIAO Ya-jun,YU Shan-shan. Tacrolimus Ointment Combined with 308 Excimer Laser in the Treatment of VitiligoVulgaris and its Effect on Peripheral Blood CD4+/CD8+, IL-17, IL-22[J].Medical Aesthetics and Beauty,2021,(1):82-85.
点击复制

 他克莫司软膏联合308准分子光治疗寻常型白癜风及对外周血CD4+/CD8+、
IL-17、IL-22的影响
()
分享到:

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年1期
页码:
82-85
栏目:
出版日期:
2021-01-10

文章信息/Info

Title:
 Tacrolimus Ointment Combined with 308 Excimer Laser in the Treatment of Vitiligo
Vulgaris and its Effect on Peripheral Blood CD4+/CD8+, IL-17, IL-22
文章编号:
1008-6455(2021)01-0082-04
作者:
 钱 俐缪亚军余珊珊
Author(s):
 QIAN LiMIAO Ya-junYU Shan-shan
关键词:
 [关键词]寻常型白癜风他克莫司软膏308准分子光疗效CD4+/CD8+IL-17IL-22
Keywords:
 Key words: vitiligo vulgaris tacrolimus ointment 308 excimer laser CD4+/CD8+ IL-17 IL-22
分类号:
R758.4+1
文献标志码:
A
摘要:
[摘要]目的:观察他克莫司软膏联合308准分子光治疗寻常型白癜风的临床观察及对患者外周血中T细胞亚群及血清中IL-17、
IL-22水平的影响。方法:选择2014年12月-2016年12月在南通市通州区人民医院检查的白癜风患者85例,根据随机数字法将
患者分为对照组和治疗组,对照组采用308准分子光常规治疗,治疗组在308准分子光治疗基础上加用0.1%他克莫司软膏,比
较各组患者治疗前后的临床症状及外周血中T细胞亚群及血清中IL-17、IL-22的水平。结果:治疗组总有效率为95.35%,显
著高于对照组的80.95%,差异有统计学意义(P <0.05)。两组患者治疗后,外周血中CD3+、CD4+、CD4+/CD8+的水平均显著升
高,差异有统计学意义(P <0.05)。治疗组CD3+、CD4+、CD4+/CD8+的水平分别为(69.37±3.58)%、(38.93±2.11)%、
1.56±0.16,对照组分别为(67.24±3.92)%、(37.42±2.17)%、1.41±0.18,两组CD3+、CD4+水平比较差异无统计学意
义(P >0.05),CD4+/CD8+比较差异有统计学意义(P<0.05)。两组患者治疗后,血清中IL-17、IL-22的水平均显著下降,差异
有统计学意义(P<0.05)。治疗后,治疗组血清中IL-17、IL-22的水平分别为(29.36±3.29)pg/ml、(20.37±2.61)pg/ml,
均显著低于对照组的(33.54±4.21)pg/ml、(28.57±2.48)pg/ml,差异有统计学意义(P<0.05)。两组患者均出现皮肤瘙
痒、水疱、灼烧感、红斑等不良反应,两组不良反应发生率比较差异无统计学意义(P >0.05)。结论:他克莫司软膏联合
308准分子光治疗寻常型白癜风的疗效确切,可降低患者血清中IL-17、IL-22的水平,升高外周血中CD3+、CD4+、CD4+/CD8+的
水平。

Abstract:
Abstract: Objective To observe the effect of tacrolimus ointment combined with 308 excimer laser on vitiligo vulgaris and the
peripheral blood T cell subsets, IL-17 and IL-22. Methods 85 patients with vitiligo vulgaris diagnosed by Nantong Tongzhou
District People’s Hospital from December 2014 to December 2016 were slected. The patients were divided into the control group
and the treatment group randomly. The control group was treated with 308 excimer laser routine treatment, and the treatment
group was treated with 0.1% tacrolimus ointment and 308 excimer laser therapy. The levels of T-cell subsets, IL-17 and IL-22
in serum were determined. Results The total effective rate was 95.35% in the treatment group, which was significantly higher
than that in the control group(80.95%), the difference was statistically significant(P <0.05). The levels of CD3+, CD4+, CD4+/
CD8+ in serum in two groups were significantly increased after treatment (P <0.05). After the treatment, the levels of CD3+,
CD4+, CD4+/CD8+ in the treatment group were (69.37±3.58)%, (38.93±2.11)% and 1.56±0.16, and those of the control group
were (67.24±3.92)%, (37.42±2.17)%, 1.41±0.18. The blood levels of CD3+ and CD4+ were not significantly different between
the two groups (P >0.05), and there was a significant difference in the levels of CD4+/CD8+ (P <0.05). After treatment, the level
of IL-17 and IL-22 of the treatment group were (29.36±3.29)pg/ml and (20.37±2.61)pg/ml, which were significantly lower than
those of the control group [(33.54±4.21)pg/ml and (28.57±2.48)pg/ml, P <0.05]. Adverse reactions in two groups were pruritus,
blisters, burning sensation and erythema, and there were no significant differences in the incidence of adverse reactions between
the two groups (P >0.05). Conclusion Tacrolimus ointment combined with 308 excimer laser treatment of vitiligo vulgaris was
effective, it can reduced the serum levels of IL-17 and IL-22 and increase the blood levels of CD3+, CD4+, CD4+/CD8+.

相似文献/References:

[1]徐 含. 医用愈肤生物膜对面部激素依赖性皮炎患者皮肤功能及DLQI的影响[J].中国美容医学,2019,(03):70.
 XU Han.Effects of Medical Skin Healing Biofilm on Skin Function and DLQI in Patients withFacial Hormone Dependent Dermatitis[J].Medical Aesthetics and Beauty,2019,(1):70.
[2] 李 辉. 舒敏仪联合他克莫司及薇诺娜舒敏保湿特护霜治疗面部糖皮质激素依赖性皮炎疗效分析[J].中国美容医学,2020,(7):29.
 LI Hui. Analysis of the Effi cacy of Sensitive Instrument Combined with Tacrolimus andWinona Sumin Moisturizing Cream in the Treatment of Glucocorticoid-dependentDermatitis[J].Medical Aesthetics and Beauty,2020,(1):29.
[3] 任 虎. 毫火针辅助308nm准分子光联合他克莫司软膏对白癜风患者疗效及免疫功能的影响[J].中国美容医学,2021,(3):102.
  REN Hu. Effect of Millifire Needle Assisted 308nm Excimer Laser Combine with TacrolimusOintment on Immune Function of Patients with Vitiligo[J].Medical Aesthetics and Beauty,2021,(1):102.
[4]马荣河,杨德银.卤米松乳膏联合他克莫司软膏治疗神经性皮炎疗效观察[J].中国美容医学,2022,(3):44.
 MA Ronghe,YANG Deyin.Observation on the Clinical Efficacy of Halometasone Cream Combined with Tacrolimus Ointment in the Treatment of Neurodermatitis[J].Medical Aesthetics and Beauty,2022,(1):44.
[5]高 凤,刘姝晨,周荣新.梅花针联合他克莫司软膏治疗头部脂溢性皮炎的有效性和安全性研究[J].中国美容医学,2023,(9):168.[doi:10.15909/j.cnki.cn61-1347/r.005861]
 GAO Feng,LIU Shuchen,ZHOU Rongxin.Effectiveness and Safety of Plum-blossom Needle Combined with Tacrolimus Ointment in the Treatment of Seborrheic Dermatitis on Scalp[J].Medical Aesthetics and Beauty,2023,(1):168.[doi:10.15909/j.cnki.cn61-1347/r.005861]
[6]薛银萍,晏 欢,缪红莉.双维度强化护理在点阵CO2激光联合他克莫司软膏治疗白癜风中的应用[J].中国美容医学,2023,(10):171.[doi:10.15909/j.cnki.cn61-1347/r.005930]
 XUE Yinping,YAN Huan,MIAO Hongli.Application of Two-dimension Intensive Nursing in the Treatment of Vitiligo with Fractional CO2 Laser Combined with Tacrolimus Ointment[J].Medical Aesthetics and Beauty,2023,(1):171.[doi:10.15909/j.cnki.cn61-1347/r.005930]
[7]阳 眉,龙 莉,冯燕艳,等.0.03%他克莫司软膏联合多磺酸粘多糖乳膏治疗面部单纯糠疹的效果观察[J].中国美容医学,2024,(2):73.[doi:10.15909/j.cnki.cn61-1347/r.006139]
 Y ANG Mei,LONG Li,FENG Yanyan,et al.Observation on Effect of 0.03% Tacrolimus Ointment Combined with Mucopolysaccharide Polysulfate Cream in the Treatment of Facial Pityriasis Simplex?/html>[J].Medical Aesthetics and Beauty,2024,(1):73.[doi:10.15909/j.cnki.cn61-1347/r.006139]

更新日期/Last Update: 2021-02-02