«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:

期数:

2021年3期

页码:

76-79

栏目:

出版日期:

2021-03-10

文章信息/Info

Title:

 Effects of Nalbuphine on Stress Response and Emergence Agitation in Children with
Cleft Lip and Palate Repair

文章编号:

1008-6455(2021)03-0076-04

作者:

 武 婷¹; 2 ; 郭亚琨¹; 2 ; 李 乐¹; 2 ; 张丽娜¹; 2;  潘 旭¹; 2 ; 王 智¹; 2

Author(s):

 WU Ting1; 2;  GUO Ya-kun1; 2; LI Le1; 2;  ZHANG Li-na1; 2;  PAN Xu1; 2;  WANG Zhi1; 2

关键词:

 [关键词]纳布啡; 小儿; 唇腭裂; 应激反应; 苏醒期躁动

Keywords:

 Key words: nalbuphine;  children;  cleft lip and palate;  stress response;  emergence agitation

分类号:

R782.2+1

文献标志码:

A

摘要:

[摘要]目的：探讨纳布啡在预防小儿唇腭裂手术患者应激反应及苏醒期躁动方面的临床效果。方法：选取2019年9月-2019年
12月在西安交通大学口腔医院整形外科就诊的100例小儿唇腭裂手术患者，随机分为纳布啡组（N组）和对照组（C组）。其
中，N组患者在麻醉诱导时按公斤体重0.2mg推注纳布啡，而C组患者则给予同等剂量且含0.9%氯化钠的注射液。在麻醉诱导
前(T0)、术毕(T1)和术后30min(T2)采集两组患者的外周静脉血测定应激反应指标（如：血糖、皮质醇和去甲肾上腺素），术
毕记录苏醒指标（如:自主呼吸恢复时间和苏醒时间），并利用Riker镇静-躁动评分标准评价两组患者苏醒期的躁动情况。
结果：T0时两组患者体内各项应激指标所呈现的差异性无统计学意义（P ＞0.05）；与T0时相比，两组患者体内各项应激指
标含量在T1和T2时明显升高，且具有统计学意义（P ＜0.05）；与C组相应时刻相比，N组患者体内各项应激指标数值在T1和
T2时期明显降低，且差异性具有统计学意义（P ＜0.05）。与此同时，两组患者在术毕时苏醒指标差异性比较无统计学意
义（P ＞0.05）。与C组患者相比，N组患者在苏醒期的躁动发生率显著降低，且Riker镇静-躁动评分值也明显降低，其数值
差异具有统计学意义（P ＜0.05）。结论：在小儿唇腭裂手术中，纳布啡可有效降低患者的应激反应水平，能够降低患者在苏
醒期躁动的程度及其发生频率，具有良好的镇静效果，且不会影响患者苏醒期的恢复情况，值得在小儿临床麻醉上推广应用。

Abstract:

Abstract:Objective This study aims to investigate the clinical effects of nabulphine on the prevention of stress response and
emergence agitation in children with cleft lip and palate operation. Methods A total of 100 patients undergoing pediatric
cleft lip and palate surgery at the Department of Plastic Surgery, Stomatological Hospital of Xi’an Jiaotong University from
September 2019 to December 2019 were randomly divided into nalbuphine group (group N) and control group (group C).
Among them, patients in group N were injected with nbuphine at 0.2mg per kg of body weight during anesthesia induction,
and patients in group C were given the same dose of 0.9% sodium chloride injection. Peripheral venous blood of the two
groups was collected at three periods before induction of anesthesia (T0), after surgery (T1) and 30 min after surgery (T2) to
measure stress response indicators (e.g., blood glucose,cortisol and noradrenaline),indicators of resuscitation (e.g., recovery
time of spontaneous breathing and time of resuscitation) were recorded at the end of the operation, and use the Riker sedationrestlessness
scale to evaluate the emergence agitation of the two groups of patients. Results There was no statistically
significant difference in various stress indicators between the two groups at T0（P ＞0.05）.Compared with T0,the difference
of various stress indicators between the two groups at T1 and T2 were significantly increased,and presented statistically
significant differences (P ＜0.05).Compared with group C at the corresponding time, the values of various stress indicators in
group N decreased significantly at T1 and T2, and the difference was statistically significant (P ＜0.05). Meanwhile, there was
no significant difference in the recovery index between the two groups after surgery（P ＞0.05）. Compared with group C, the
incidence of agitation in group N was significantly reduced during the recovery period, and the Riker sedation-agitation score
also decreased significantly(P ＜0.05). Conclusion In children’s cleft lip and palate surgery, nabulphine can effectively reduce
the level of stress response of patients, can reduce the degree of restlessness and frequency of patients in the recovery period.
Besides, it will not affect the recovery of patients in the recovery period. Thus nabulphine has a good sedative effect.It is worth
promoting the application of pediatric clinical anesthesia.

常用功能

更新日期/Last Update: 2021-04-13