[1] 熊友华,邓 映,杨洪秋,等. Q开关1 064nm Nd:YAG 激光联合纳晶微针治疗黄褐斑疗效分析[J].中国美容医学,2021,(4):22-26.
　 XIONG You-hua,DENG Ying,YANG Hong-qiu,et al. Clinical Observation on the Treatment of Melasma with Q-switch 1 064nm Nd:YAGLaser and Nanocrystal Microneedle[J].Medical Aesthetics and Beauty,2021,(4):22-26.
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 Q开关1 064nm Nd:YAG 激光联合纳晶微针治疗黄褐斑疗效分析
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年4期
页码:
22-26
栏目:
出版日期:
2021-04-10

文章信息/Info

Title:
 Clinical Observation on the Treatment of Melasma with Q-switch 1 064nm Nd:YAG
Laser and Nanocrystal Microneedle
文章编号:
1008-6455（2021）04-0022-04
作者:
 熊友华; 邓 映; 杨洪秋; 杜 宇
Author(s):
 XIONG You-hua; DENG Ying; YANG Hong-qiu; DU Yu
关键词:
 [关键词]黄褐斑; Q开关1 064nm Nd:YAG激光; 纳晶针; 氨甲环酸; 联合治疗
Keywords:
 Key words:melasma; Q-switch 1064nm Nd:YAG laser; nanoneedle;  tranexamic acid;  combined therapy
分类号:
R758.4
文献标志码:
A
摘要:
[摘要]目的：探究Q开关1 064nm Nd:YAG激光联合纳晶微针治疗黄褐斑的疗效及安全性。方法：选取2017年9月-2019年9月于
笔者科室就诊的86例黄褐斑患者，随机分为治疗组(n =43)和对照组(n =43)。治疗组：采用Q开关1 064nm Nd:YAG激光联合
纳晶微针导入氨甲环酸注射液治疗；对照组：采用Q开关1 064nm Nd:YAG激光治疗，每次治疗间隔2周，4次为1个疗程，两
组均治疗2个疗程。治疗结束后比较两组MASI评分、临床疗效、满意度及不良反应发生率，随访12周观察复发率。结果：
治疗组MASI评分降低、有效率以及满意度均高于对照组，治疗组不良反应发生率、复发率均低于对照组，差异具有统计学
意义(P ＜0.05)。结论：Q开关1 064nm Nd:YAG激光联合纳晶微针导入氨甲环酸治疗黄褐斑较单独使用激光治疗效果好，不良
反应发生率低，患者满意度高，值得临床推广应用。

Abstract:
Abstract:Objective To investigate the effects and safety of Q-switch 1 064nm Nd:YAG laser combined with nanocrystal
microneedle in treatment with melasma. Methods 86 patients with melasma in our hospital from September 2017 to September
2019 were selected and randomly divided into treatment group (n =43) and control group (n =43). The control group were
applied Q-switch 1 064nm Nd:YAG laser, and the treatment group were applied Q-switch 1 064nm Nd:YAG laser combined
with nanocrystal microneedle. nanocrystals were used to assist transdermal administration of tranexamic acid injection. Each
treatment interval was 2 weeks, 4 times as a course of treatment, and the two groups were applied for 2 courses. The MASI
scores, clinical efficacy, patient satisfaction and the incidence of adverse reactions were compared between the two groups, and
follow up for 12 weeks to observed the recurrence rate after treatment. Results The decrease of MASI scores, effective rate
and satisfaction in the treatment group were all higher than those in the control group, while the incidence and recurrence rates
of the adverse reactions were lower than the control group. The difference was statistically significant (P ＜0.05). Conclusion
Q-switched 1 064nm Nd:YAG laser combined with nanocrystal microneedle infusion of tranexamic acid in the treatment of
melasma was more effective than laser treatment only,with less adverse reactions, and the patient’s satisfaction was higher,and
was worthy of clinical promotion and application.

相似文献/References:

[1] 姚松领,闫小宁,付海鹏,等. 刮痧法治疗黄褐斑的Meta分析及试验序贯分析[J].中国美容医学,2020,(9):100.
　 YAO Song-ling,YAN Xiao-ning,FU Hai-peng,et al. Meta Analysis and Sequential Analysis of Scraping Therapy for Chloasma[J].Medical Aesthetics and Beauty,2020,(4):100.
[2] 何 金,任先志,周 燕. 补肾祛斑汤联合低能量Q开关激光对黄褐斑患者抗氧化功能与皮肤色斑及屏障的影响研究[J].中国美容医学,2020,(10):160.
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[3]. 阶段性护理在调Q激光治疗黄褐斑围术期的应用价值探讨毛栋玲1，熊莹帆2，安维娟3[J].中国美容医学,2021,(10):171.
　 MAO Dong-ling,XIONG Ying-fan,AN Wei-juan. Application Value of Staged Nursing in Perioperative Chloasma Treated withQ-switched Laser[J].Medical Aesthetics and Beauty,2021,(4):171.

更新日期/Last Update: 2021-05-11